Chemical composition and antifungal potential of Brazilian propolis against Candida spp.

Freires, Irlan Almeida; Queiroz, V.C.P.P.; Furletti, Vivian Fernandes; Ikegaki, Masaharu; Alencar, Severino Matias de; Duarte, Marta Cristina Teixeira; Rosalen, Pedro Luiz

doi:10.1016/j.mycmed.2016.01.003

Cited by 71 publications

(73 citation statements)

References 33 publications

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“…Inhibition of bacterial RNA polymerase has been also considered for galangin, pinocembrin, and CAPE (Speciale et al, 2006). The antimicrobial activity of Brazilian red propolis is thought to depend on its peculiar content in isoflavones (Freires et al, 2016). …”

Section: Propolismentioning

confidence: 99%

“…The ethanolic extracts of Iranian propolis have shown strong anti- C. albicans activity imputable to inhibition of germ tube development by phenolic, aromatic, and aliphatic acids (Haghdoost et al, 2016). Another ethanolic extract containing CAPE and other caffeic acid derivatives has been effective against C. albicans, C. dubliniensis, C. glabrata, C. krusei, C. tropicalis , and C. parapsilosis , with an MFC of 125-500 mg/L, while red Brazilian propolis rich in triterpenes and isoflavones, such as medicarpin, vestitol and formononetin, has shown the same MFC range (Freires et al, 2016). …”

Section: Propolismentioning

confidence: 99%

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Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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Honeybees produce honey, royal jelly, propolis, bee venom, bee pollen, and beeswax, which potentially benefit to humans due to the bioactives in them. Clinical standardization of these products is hindered by chemical variability depending on honeybee and botanical sources, but different molecules have been isolated and pharmacologically characterized. Major honey bioactives include phenolics, methylglyoxal, royal jelly proteins (MRJPs), and oligosaccharides. In royal jelly there are antimicrobial jelleins and royalisin peptides, MRJPs, and hydroxy-decenoic acid derivatives, notably 10-hydroxy-2-decenoic acid (10-HDA), with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, and anti-aging activities. Propolis contains caffeic acid phenethyl ester and artepillin C, specific of Brazilian propolis, with antiviral, immunomodulatory, anti-inflammatory and anticancer effects. Bee venom consists of toxic peptides like pain-inducing melittin, SK channel blocking apamin, and allergenic phospholipase A2. Bee pollen is vitaminic, contains antioxidant and anti-inflammatory plant phenolics, as well as antiatherosclerotic, antidiabetic, and hypoglycemic flavonoids, unsaturated fatty acids, and sterols. Beeswax is widely used in cosmetics and makeup. Given the importance of drug discovery from natural sources, this review is aimed at providing an exhaustive screening of the bioactive compounds detected in honeybee products and of their curative or adverse biological effects.

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Section: Propolismentioning

confidence: 99%

Section: Propolismentioning

confidence: 99%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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“…It is tempting to speculate that a similar mechanism contributes to the action of p -cresol. Notably, several other phenolic compounds have been reported to positively or negatively affect Candida viability, morphology, and biofilm formation; these include but are not limited to tyrosol (67, 68), p -coumaric acid (69), ferulic acid (70), caffeic acid (71), boric acid (72), and eugenol (73). These observations, together with the identification of more-complex inhibitors (74, 75), may lead to the identification of general structural principles of compounds that govern Candida proliferation and the yeast-to-hypha transition.…”

Section: Discussionmentioning

confidence: 99%

Interspecies Interactions between Clostridium difficile and Candida albicans

Leeuwen

Peet

Bikker

et al. 2016

mSphere

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Candida albicans and Clostridium difficile are two opportunistic pathogens that reside in the human gut. A few studies have focused on the prevalence of C. albicans in C. difficile-infected patients, but none have shown the interaction(s) that these two organisms may or may not have with each other. In this study, we used a wide range of different techniques to better understand this interaction at a macroscopic and microscopic level. We found that in the presence of C. albicans, C. difficile can survive under ambient aerobic conditions, which would otherwise be toxic. We also found that C. difficile affects the hypha formation of C. albicans, most likely through the excretion of p-cresol. This ultimately leads to an inability of C. albicans to form a biofilm. Our study provides new insights into interactions between C. albicans and C. difficile and bears relevance to both fungal and bacterial disease.

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“…Many compounds in plant composition can also be found in green propolis, such as artepillin C, flavonoids and p-coumaric acid, which are associated with its antioxidant capacity (Guimarães et al, 2012). Additionally, flavonoids and phenolic acids in green propolis have antifungal activities for typical agricultural, food, medical and odontological fungi (Ngatu et al, 2011;Freires et al, 2016;Martini et al, 2017). However, propolis is a tough resin that cannot be consumed in its natural form; thus, resin is typically transformed into a powder and extracted in an alcoholic or aqueous medium (Mello and Hubinger, 2012).…”

Section: Introductionmentioning

confidence: 99%

Benefits of superfine grinding method on antioxidant and antifungal characteristic of Brazilian green propolis extract

Augusto-Obara

Oliveira

Glória

et al. 2019

Sci. agric. (Piracicaba, Braz.)

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Green propolis is found only in Brazil and due to its important biological characteristics, the food industry views it as a rich source of bioactive compounds. However, an extract must be produced for its application, which is difficult considering the rigid characteristics of raw propolis. Superfine grinding, a process capable of reducing particle size, enables the extraction of most bioactive compounds in propolis. This study evaluated the influence of grinding on size characteristics, antioxidant and antifungal properties of Brazilian green propolis for food preservation. The propolis powder was produced through six different types of grinding (different sieves and rpm), and its quality was evaluated by scanning electron microscopy-energy dispersive X-ray spectroscopy. After grinding, extracts and bioactive assays were produced and the total phenolic content, antioxidant and antifungal capacity were determined. The data showed that the grinding process affected all the results of bioactive assays used. Treatment B (sieve 0.08 mm, 12,000 rpm) presented statistically significant values for the bioactivity assays and thus antifungal activity against Rhizopus stolonifer (doses 0-5 %) was tested only for the control (standardized size without superfine grinding) and treatment B. Both treatments showed antifungal activity, but the control provided more effective mycelial growth inhibition (lower dose 1 %).Superfine grinding increased the antioxidant activity, although this behavior was not observed in the antifungal assay. Despite these results, green propolis extracts present important biological effects that indicate their use as food preservatives to extend shelf life of food products.

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Chemical composition and antifungal potential of Brazilian propolis against Candida spp.

Cited by 71 publications

References 33 publications

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

Interspecies Interactions between Clostridium difficile and Candida albicans

Benefits of superfine grinding method on antioxidant and antifungal characteristic of Brazilian green propolis extract

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