Chemical Composition and Antioxidant, Antinociceptive, and Anti‐inflammatory Activities of Four Amazonian Byrsonima Species

Abstract

Species of the Byrsonima genus are widely used in Brazil, especially for the treatment of gastrointestinal disorders. However, species from the Amazonian region are still poorly studied. Thus, we studied the antioxidant, antinociceptive, and anti-inflammatory activities of for Amazonian species, Byrsonima crispa, Byrsonima duckeana, Byrsonima garcibarrigae, and Byrsonima incarnata. Phenolic composition was determined by chemical and chromatographic methods. The aqueous extracts were evaluated in DPPH , ABTS , and superoxide (O ) tests, LPS-activated macrophage assay, and formalin test. All species contained a high phenolic and flavonoid content. We identified 15 phenolic compounds, including phenolic acids, hydroxycinnamic acids, flavonoids, and catechins. The extracts showed high antioxidant activity and were more active than quercetin at inhibiting nitric oxide release in the LPS-activated macrophage assay. B. duckeana and B. garcibarrigae showed higher in vivo antinociceptive and anti-inflammatory activities. B. garcibarrigae presented significant effect on the early phase of the formalin test, pointing to an antinociceptive mechanism distinct from traditional anti-inflammatory medicines. In conclusion, the pharmacological potential of these species is closely related to their flavonoid-rich chemical composition, which seems to act through antioxidant mechanisms. Copyright © 2017 John Wiley& Sons, Ltd.

UHPLC-(ESI)-HRMS and NMR-Based Metabolomics Approach to Access the Seasonality of Byrsonima intermedia and Serjania marginata From Brazilian Cerrado Flora Diversity

“…Some of these plant species include Byrsonima intermedia and Serjania marginata , which present similar ethnopharmacological characteristics and have been found to be promising for future application in phytotherapy aimed at the treatment of inflammatory diseases. The hydroethanolic extracts obtained from the leaves of each of these species demonstrated potential gastroprotective ( Arruda et al, 2009 ; Périco et al, 2015 ; dos Santos et al, 2019 ), anti-inflammatory ( Moreira et al, 2011 ; Salinas-Sánchez et al, 2017 ), antioxidant ( Heredia-Vieira et al, 2015 ; Guilhon-Simplicio et al, 2017 ), analgesic ( Di Stasi et al, 1988 ; Verdam et al, 2017 ) activities and absence of toxicity in the acute models evaluated ( Santos et al, 2012 ; Périco et al, 2015 ; dos Santos et al, 2019 ).…”

­Chemical profiling and biological activity of Peperomia blanda (Jacq.) Kunth

“…The phenol and flavonoid contents in each solvent extract led to different observations of antioxidant activities. Natural antioxidants like phenolic acids and flavonoids are interesting alternatives to modulate inflammation, and to inhibit the related oxidative processes ( Guilhon-Simplicio et al, 2017 ). Consequently, further isolation of new flavonoids from this plant are warranted for drug discovery.…”

Characterization and oxidative stability of oils and bioactive compounds of the fruits ofByrsonima cydoniifoliaA. Juss. at different ripening stages

“…28 Furthermore, the values of total phenols in our study were superior in relation to those of aqueous extracts from stem barks of B. crispa, B. duckeana, B. garcibarrigae and B. incarnata, of 1.64, 1.46, 2.2, and 2.51 g GAE kg −1 , respectively. 29 In contrast, only one report had a higher content (52.55 g GAE 100 kg −1 ), probably due to the combined extract of the aqueous and ethanolic phases, in the case of hydroethanolic, of ripe fruit pulp of B. cydoniifolia. 26 The content of tannins did not show differences between stages; however, we observed a reduction in tannins in the ripe fruit.…”