Chemical Composition and Antiproliferative Activity of Supercritical Extract of<i>Citrus grandis</i>(L.) Osbeck Fruits from Korea

Gyawali, Rajendra; Jeon, Deok Hyeon; Moon, Jeong-Yong; Kim, Hyoenji; Song, Yeon Woo; Hyun, Ho Bong; Jeong, Dong-Kee; Cho, Somi Kim

doi:10.1080/0972060x.2012.10662594

Cited by 16 publications

(5 citation statements)

References 33 publications

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“…Sahay [11] reviewed the pharmacological effects of EOs which have antibacterial and anticancer activities. EOs have little toxicity and few side effects, and are generally recognized as safe in food, and may become new natural resources for the chemoprevention of cancer [12,13].…”

Section: Introductionmentioning

confidence: 99%

Extraction of ‘Gannanzao’ Orange Peel Essential Oil by Response Surface Methodology and its Effect on Cancer Cell Proliferation and Migration

Liu

Deng

et al. 2019

Molecules

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The essential oil of ‘Gannanzao’ orange peel was extracted by hydrodistillation, and the extraction conditions were optimized by Box–Behnken response surface methodology. The components of essential oil were analyzed by GC-MS. Thirty-nine different components were detected, accounting for 99.59% of the total oil. Limonene (88.07%) was the prominent component. The optimal extraction conditions were as follows: liquid material ratio of 8.4:1 (mL/g), sodium chloride concentration of 5.3%, and distillation time of 3.5 h. The Cell Counting Kit-8 assay showed that ‘Gannanzao’ orange peel essential oil had good dose-dependent inhibition effect on the proliferation of HepG2 hepatoma cells and HCT116 colorectal cancer cells. When the concentration of the essential oil was 0.6 μL/mL or higher, the viability rate of both cancer cells became lower than 13.0%. The transwell assay indicated the essential oil can inhibit migration of both cancer cells at the concentration of 0.3 μL/mL.

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Section: Introductionmentioning

confidence: 99%

Extraction of ‘Gannanzao’ Orange Peel Essential Oil by Response Surface Methodology and its Effect on Cancer Cell Proliferation and Migration

Liu

Deng

et al. 2019

Molecules

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“…Meanwhile, essential oils obtained by pressing from Japanese and Kenyan peels showed limonene content of 87.1% and 94.8%, respectively (Sawamura et al, 2001;Njoroge et al, 2005). On the contrary, very low limonene content (3.7%) was determined in Korean pomelo volatiles extracted by supercritical fluid, which could be explained by more complex composition of supercritical extracts (Gyawali et al, 2012). These discrepancies suggest that both material origin and extraction technique could largely determine the composition of the essential oil products and that rationalization for extraction technique should be individually made for each purpose of use.…”

Section: The Results Of Gc-msmentioning

confidence: 91%

“…Such variance in pomelo essential oil composition could be attributable to the variety of the pomelo plant, the plant part, used extraction technique and process parameters. To date, numerous extraction methods including microwave-assisted hydrodistillation and supercritical CO2 extraction have been attempted to isolate essential oil bearing extracts from pomelo materials (Hien et al, 2018;Gyawali et al, 2012). However, such processes lack applicability in producing essential oil at commercial scale due to their high operational costs, complexity and limited scalability.…”

Section: Introductionmentioning

confidence: 99%

Extraction process optimization and characterization of the Pomelo (Citrus grandis L.) peel essential oils grown in Tien Giang Province, Vietnam

Bach¹

2020

Natural Volatiles and Essential Oils

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Hydrodistillation was used to obtain the essential oil from pomelo (Citrus grandis L.) peels collected in Vietnam. The effects of extraction variables including size of material, temperature, extraction time, and water-to-material ratio on the yield of essential oil were investigated. In addition, to assess the quality of pomelo essential oil, the chemical composition was compared. The optimized conditions were as follows: material size of grind, temperature 120 °C, water to material ratio 5 mL/g, and extraction time 105 min., respectively. The chemical composition of the pomelo oil was then determined by GC-MS, where 5 components were identified, of which, limonene was the highest (97.1%). This method can be considered as a green method of extraction method as it is less energy intensive process and offers high performance. The results are expected to aid in justification of hydrodistillation in industrial applications and in refining of extraction parameters.

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“…Since ancient times, CGT has been recognized as a homology of medicine and food because of its excellent performance for treating cough and expectorant (Li et al, 2014). Moreover, many other physiological activities of CGT, such as antioxidant (Han et al, 2014), anti-inflammatory (Jayaraman et al, 2012), antimicrobial (Wang et al, 2012), antiproliferative (Gyawali et al, 2013), anti-atherosclerotic, and hypolipidemic (Kong et al, 2020;Raasmaja et al, 2013), have been confirmed by modern studies. It is noteworthy that the traditional concept of "the older the better" has been applied to CGT in China for a long time.…”

Section: Introductionmentioning

confidence: 97%

Diversity in storage age enables discrepancy in quality attributes and metabolic profile of Citrus grandis “Tomentosa” in China

Wei,

Hu,

et al. 2024

Journal of Food Science

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The folk proverb “the older, the better” is usually used to describe the quality of Citrus grandis “Tomentosa” (CGT) in China. In this study, CGT aged for 6‐, 12‐, 16‐, and 19‐years were collected for the investigation of infusion color, main bioactive components, antioxidant activity, metabolic composition, and pathway. The results found that infusion color, the total phenolic and flavonoid, and antioxidant activity of CGT were obviously changed by aging process. Through untargeted metabolomics, 55 critical metabolites were identified to in discrimination of CGT with different storage ages, mainly including phenylpropanoids, lipids, and organic oxygen compounds. Twenty compounds that showed good linear relationships with storage ages could be used for year prediction of CGT. Kyoto encyclopedia of genes and genomes enrichment pathway analysis uncovered important metabolic pathways related to the accumulation of naringin, kaempferol, and choline as well as the degradation of benzenoids, thus supporting that aged CGT might be more beneficial to health. Correlation analysis provided that some key metabolites with bitter taste and biological activity were involved in the darkening and reddening of CGT infusion during aging, and total phenolic and flavonoid were more strongly associated with the antioxidant activity of CGT. This study systematically revealed the quality changes and key metabolic pathways during CGT aging at first time.Practical ApplicationThis study reveals the differences in quality attributes and metabolic profile between CGT with different storage ages, providing guidance for consumers' consumption, and also providing more scientific basis for the quality evaluation and improvement of CGT.

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Chemical Composition and Antiproliferative Activity of Supercritical Extract ofCitrus grandis(L.) Osbeck Fruits from Korea

Cited by 16 publications

References 33 publications

Extraction of ‘Gannanzao’ Orange Peel Essential Oil by Response Surface Methodology and its Effect on Cancer Cell Proliferation and Migration

Extraction of ‘Gannanzao’ Orange Peel Essential Oil by Response Surface Methodology and its Effect on Cancer Cell Proliferation and Migration

Extraction process optimization and characterization of the Pomelo (Citrus grandis L.) peel essential oils grown in Tien Giang Province, Vietnam

Diversity in storage age enables discrepancy in quality attributes and metabolic profile of Citrus grandis “Tomentosa” in China

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