Chemical Composition and Biological Activities of Gerbera anandria

Abstract

Gerbera anandria (Compositae) was extracted with 75% ethanol and the residue was fractionated using light petroleum, chloroform and ethyl acetate. The constituents of the extracts were separated by column chromatography employing solvents of different polarity. Column chromatography of the light petroleum fraction resulted in the isolation of methyl hexadecanoate, while the chloroform fraction afforded xanthotoxin, 2-hydroxy-6-methylbenzoic acid, 7-hydroxy-1(3H)-isobenzofuranone, a mixture of β-sitosterol and stigmasterol, and 8-methoxysmyrindiol and the ethyl acetate fraction gave gerberinside, apigenin-7-O-β-D-glucopyranoside and quercetin. A new coumarin, 8-methoxysmyrindiol, was found. The chemical structures of the isolated compounds were established by MS and NMR (HSQC, HMBC). Free radical scavenging and cytotoxic activities of crude extracts and 8-methoxysmyrindiol were further investigated. The ethyl acetate phase exerted the strongest DPPH free radical scavenging activity in comparison to the other fractions. The coumarin 8-methoxysmyrindiol demonstrated cytotoxicity against multiple human cancer cell lines, with the highest potency in HepG2 cells.

Chemical constituents and coagulation activity of Agastache rugosa

“…13 C-NMR (CDCl 3 , 100 MHz) δ : 174.2 (C-1), 51.35 (C-1′), 34.11 (C-2′), 24.96 (C-3), 29.15 (C-4), 29.24 (C-5), 29.34 (C-6), 29.67 (C-7, C-11), 29.58 (C-12), 29.44 (C-13), 31.91 (C-14), 22.67 (C-15), 14.06 (C-16). The above spectral data were basically consistent with those reported previously [ 17 ] and thus, compound 1 was identified as methyl hexadecanoate.…”

Isolation and characterization of six flavonoids from the leaves of Sterculia foetida Linn.

“…Thus, the structure of 2 was demonstrated to be apigenin 7-O-β-D-glucopyranoside. [8] Compound 3 was yield as a yellow amorphous powder. Its ESI-MS spectrum exhibited a pseudomolecular peak at m/z = 283.22 [M+H] + , indicating its molecular formula as C17H14O4.…”

Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

“…Compound Class/Name EE DCME ACNE 2',3'-dihydroxypuberulin [31] + 7-(2,3-dihydroxy-3-methylbutoxy)-5-hydroxy-6-methoxy-2H-1-benzopyran-2-one [32] + + coumarin derivative [33,34] [37] + italipyrone [22] + italipyrone analog [22] + γ-pyrone (chromone) 3-(acetyloxy)-2,3-dihydro-5,7-dihydroxy-6-(3-methyl-2-butenyl)-2-phenyl-4H-1-benzopyran-4-one [38] + 2,3-dihydro-5,7-dihydroxy-3-methyl-8-(3-methyl-2-butenyl)-2-(1-methylethyl)-4H-1-benzopyran-4-one [39] + Flavonoid flavone apigenin-7-O-glucoside [4] + apigenin-5-O-glucoside [40] + luteolin [41] + 3,5,6,7,8-pentamethoxyflavone [42] + 3',4',5,6,7-pentamethoxyflavone [43] + apigenin [40] + dihydroxy-dimethoxyflavone [44] + jaceosidin [45] + chrysoeriol [45] + 5,7-dihydroxy-3-methoxyflavone [44] + 5,7,4'-trihydroxy-3,6-dimethoxy-3'-prenylflavone [46] + TEDMF 1 [43] [43] + flavanone naringenin-5-O-glucoside [40] + naringenin-4 -O-glucoside [48] + naringenin-7-O-glucoside [40] + eriodictyol [49] + naringenin [40] + + flavonol quercetin-3-O-glucoside [4], hyperoside (quercetin-3-O-galactoside) [4] + kaempferol-3-O-glucoside [50] + Table 1. Cont.…”