Chemical composition and biological activity of Tanacetum audibertii (Req.) DC. (Asteraceae), an endemic species of Sardinia Island, Italy

Maxia, Andrea; Sanna, Cinzia; Piras, Alessandra; Porcedda, Silvia; Falconieri, Danilo; Gonçalves, María José; Cavaleiro, Carlos; Salgueiro, Lígia

doi:10.1016/j.indcrop.2014.10.039

Cited by 18 publications

(13 citation statements)

References 53 publications

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“…The literature data indicate that the essential oil content in the genus Tanacetum ranges between 0.1% to 6.98% [5,12,21]. Our result is close to those reported for T. audibertii (0.1%) [11] and T. chilliophyllum (0.06-0.16%) [22]. The general chemical profiling of the essential oils, the identity and percentage content of the individual components are summarized in One of the major constituents of the P. pulchrum is camphor.…”

Section: Resultssupporting

confidence: 90%

“…One of the novel ways to reduce the proliferation of microorganisms is the use of essential oils [35]. Thus, the antimicrobial activities of the essential oil of P.pulchrum were studied against eight bacterial and three fungi strains ( T. parthenium camphor -53.8%, trans-β-farnesene -8.3% [24] T. punctatum camphor -45.5%, trans-β-farnesene -7.4% [24] T. chiliophyllum camphor -32.5%, 1,8-cineol -16.1% [14] T. armenum camphor -27%, 1,8-cineol -11% [25] T. vulgare camphor -22.3-41.4%, 1,8-cineol -10.5-26.4% [26] T. pinnatum camphor -23.2%, α-penine -8.5%, camphene -7.7% [27] T. angulatum 1,8-cineol -75.3%, camphor -8.1% [22] T. praeteritum borneol -28%, 1,8-cineol -12% [3] T. audibertii artemisia keton -39.8%, trans-linalool oxide -32% [11] T. messicyticu thujone -51% [3] T. argyrophyllum cis-thujone -69.9% [13] T. balsamita carvone -52% [25] T. longifolium eudesmol -22.5%, 1,4-dimethyl azulene -13.5%, germacrone -8.2% [28] [23,24,37]. However, other publications reported that the essential oils of T. parthenium (from various regions) were resistant to E. coli, B. subtilis and S. aureus [5,38].…”

Section: Resultsmentioning

confidence: 99%

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Chemical composition and antimicrobial activity of essential oil from <i>Pyrethrum pulchrum</i> Ledeb.

et al. 2018

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The chemical composition and antimicrobial activity of the essential oil from the aerial parts of Pyrethrum pulchrum Ledeb. were investigated. Dried plant material was hydro-distillated yielding 0.1% of essential oil. The oil was analyzed by GC-MS techniques. Fifty-five compounds were identified representing 99.7% of the total oil composition. Camphor was the predominant compound (33.9%) followed by linalool (21.1%) and α-pinene (9.0%). The antimicrobial activity of the oil was determined using the disk diffusion method against Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus and Enterococcus faecalis), Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), Mycobacterium vaccae and fungi (Candida albicans, Sporidiobolus salmonicolor and Penicillum notatum). The essential oil of P. pulchrum displays an intermediate activity against selected bacteria.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Chemical composition and antimicrobial activity of essential oil from <i>Pyrethrum pulchrum</i> Ledeb.

et al. 2018

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“…The high phenolic content could explain the clear proapoptotic effect, as it is well known that this class of compounds is able to induce apoptosis via the p53 pathway [39]. Our work demonstrated for the first time the antitumor potential of Tanacetum audibertii, as only antifungal properties have been documented in the literature [52].…”

Section: Methodssupporting

confidence: 54%

Antitumor Potential and Phytochemical Profile of Plants from Sardinia (Italy), a Hotspot for Biodiversity in the Mediterranean Basin

Cappadone

Mandrone

Chiocchio

et al. 2019

Plants

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Sardinia (Italy), with its wide range of habitats and high degree of endemism, is an important area for plant-based drug discovery studies. In this work, the antitumor activity of 35 samples from Sardinian plants was evaluated on human osteosarcoma cells U2OS. The results showed that five plants were strongly antiproliferative: Arbutus unedo (AuL), Cynara cardunculus (CyaA), Centaurea calcitrapa (CcA), Smilax aspera (SaA), and Tanacetum audibertii (TaA), the latter endemic to Sardinia and Corsica. Thus, their ability to induce cell cycle arrest and apoptosis was tested. All extracts determined cell cycle block in G2/M phase. Nevertheless, the p53 expression levels were increased only by TaA. The effector caspases were activated mainly by CycA, TaA, and CcA, while AuL and SaA did not induce apoptosis. The antiproliferative effects were also tested on human umbilical vein endothelial cells (HUVEC). Except for AuL, all the extracts were able to reduce significantly cell population, suggesting a potential antiangiogenic activity. The phytochemical composition was first explored by 1H NMR profiling, followed by further purifications to confirm the structure of the most abundant metabolites, such as phenolic compounds and sesquiterpene lactones, which might play a role in the measured bioactivity.

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“…For both these reasons, the wide variety of secondary metabolites and their bioactivities, the studies about the phytochemistry of this species are currently in the limelight. In this article, we report the phytochemical analysis of a sample of D. oleoides collected from a spontaneous population growing in Sardinia Island to verify if the isolated environment may have favored the development of a peculiar secondary metabolites pattern, as we already evidenced in other species growing in restricted areas and, in particular, in Sardinian territory . In fact, Sardinia, according to ‘Conservation International’ is part of the ten ‘mini‐Hotspots’ recognizable in the Mediterranean basin.…”

Section: Introductionmentioning

confidence: 89%

New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island

Venditti

Sanna

Lorenzetti

et al. 2017

Chemistry & Biodiversity

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The phytochemical analysis of the ethanolic extract obtained from D. oleoides collected from Sardinia Island allowed the isolation of several new constituents for the species (3, 8, and 9) together with two new coumarinyl ethers (1 and 2) besides the chemotaxonomic markers of the Daphne genus (4 - 7 and 10) which are also known to possess interesting biological activities. The structure of the new compounds were elucidated by extensive spectroscopic and spectrometric analyses. The identification of these compounds gives an experimental evidence of the variability in the secondary metabolites pattern owned by populations growing in restricted area in respect to populations not confined by geographical barrier.

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Chemical composition and biological activity of Tanacetum audibertii (Req.) DC. (Asteraceae), an endemic species of Sardinia Island, Italy

Cited by 18 publications

References 53 publications

Chemical composition and antimicrobial activity of essential oil from <i>Pyrethrum pulchrum</i> Ledeb.

Chemical composition and antimicrobial activity of essential oil from <i>Pyrethrum pulchrum</i> Ledeb.

Antitumor Potential and Phytochemical Profile of Plants from Sardinia (Italy), a Hotspot for Biodiversity in the Mediterranean Basin

New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island

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