Chemical Composition and Biological Activity of Capetula and Shoots Essential Oils of <i>Senecio glaucus</i> L.

Taha, Ramadan; Zaher, Ahmed; Amro, Ahmed; Sultan, Raoof

doi:10.1080/0972060x.2020.1742797

Cited by 8 publications

(13 citation statements)

References 52 publications

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“…In this study, we showed that S. glaucus displayed strong antioxidant activity through two screening methods. The results were compared with a recent study which reported that essential oils from S. glaucus exerted a concentration-dependent DPPH scavenging activity [ 38 ]. Furthermore, Mohamed (2015) found that root methyl alcohol extract of S. glaucus growing in Egypt had an antioxidant activity with IC 50 = 79.57 ± 0.74 μ g/ml using the DPPH method [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Data from the literature on the cytotoxicity of S. glaucus are still scarce. A new study by Ramadan et al (2020) showed that S. glaucus essential oils exerted cytotoxic activity against breast cancer cells [ 38 ]. Phenolic compounds, including GA and VA, are among the best candidates for mediating anticancer activities [ 7 , 27 , 39 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

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In Vitro Antioxidant, Cytotoxic Activities, and Phenolic Profile of Senecio glaucus from Saudi Arabia

Alqahtani

Herqash

Noman

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Current treatments for complex diseases have remarkable side effects that negatively impact patients’ quality of life. Thus, natural compounds with fewer side effects represent a promising source for safe drugs. The genus Senecio is widely used in folk medicine due to its various pharmacological properties. In the present study, the total phenolic content of Senecio glaucus, which is grown in Saudi Arabia, was assessed using the Folin-Ciocalteau colorimetric method. Scavenging DPPH and ABTS assays were utilized to determine the antioxidant properties of S. glaucus fractions, and MTT assay was used to screen the cytotoxic activity of S. glaucus against various cancer cells. In addition, HPLC-UV was utilized to detect the presence of two phenolic acids, namely, vanillic acid (VA) and gallic acid (GA). Among all fractions tested, S. glaucus chloroform fraction (SGCF) yielded the highest value (125.3 mg·GA/g) in terms of total phenolic content. SGCF also exhibited the highest scavenging activities (76.7 and 74.1%) on both DPPH and ABTS assays, respectively. Similarly, SGCF also possessed the most potent cytotoxic activity against the MCF-7 cell line, with an IC50 value of 41.8 μg/ml. The validated HPLC method confirmed the presence of VA (4.8 μg/mg DW) and GA (3.9 μg/mg DW) in SGCF. Overall, our data show that S. glaucus had antioxidant and cytotoxic properties. A developed validated HPLC method which could be helpful for quantifying phenolic compounds in S. glaucus was established.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In Vitro Antioxidant, Cytotoxic Activities, and Phenolic Profile of Senecio glaucus from Saudi Arabia

Alqahtani

Herqash

Noman

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…[32] Also, the compound has been identified as the third main components of the oil obtained from the capitula and shoots of S. glaucus with relative concentrations 17.20 % and 19.90 %, respectively. [33] It is noteworthy that this sesquiterpene was the main component in the EO of S. viridis (92.70 %), [40] S. nemorensis (75.10 %), [41] and the stems, roots, and leaves of S. desfontainei (77.60 %, 46.90 %, and 42.8 %, respectively). [42] Indeed, the ethereal extract of S. punae from the Andean Puna desert showed a major peak (94.80 %), which correlated with this sesquiterpene ketone.…”

Section: Chemical Characterization Of Eo Of S Glaucus Collected From ...mentioning

confidence: 99%

Profiling Key Aroma Compounds of Senecio glaucus L. and their Antimicrobial and Antioxidant Activities: Multiplex of GC‐MS, NMR and In Silico Studies

Elghonemy,

Essa,

Osman

et al. 2024

Chemistry & Biodiversity

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Senecio plants (Asteraceae) have been used to treat a wide range of ailments in traditional medicine. Current work has unveiled the identification of EO metabolites of collected S. glaucus from Egypt's Nile delta using GC‐MS and GC‐FID. Additionally, the antimicrobial activity has been investigated. Then, radical scavenging activity was evaluated using DPPH, ABTS, and metal chelating techniques. Also, the molecular docking studies were performed for the main compounds. Fifty components were identified within 98.80% of the total mass. Sesquiterpenes and monoterpenes constitute the main components. Dehyrofukinone (27.15%), 4,5‐di‐epi‐aristolochene (10.27%), and p‐cymene (4.77%) represented the most predominant constituents. The oil has showed remarkable antifungal activity against C. glabrata and C. albicans within the MIC and MFC values of 3.13 and 1.5 µg/ml‐1 and 12.5 and 6.3 µg/ml‐1, respectively. Also, this oil inhibited the growth of the tested bacteria with MIC ranging from 12.50‐100 µg/ml‐1. In comparison to ascorbic acid and Trolox, the EO had substantial scavenging activity of DPPH and ABTS radicals with IC50 values of 313.17, 493.83, and 47. µg/mL. Phytol revealed the best binding affinities toward the active sites of Gyrase B, α‐sterol demethylase, and tyrosine kinase Hck with ΔG = ‐7.42, ‐7.78, and ‐7.44 kcal/mol, respectively.

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“…The essential oils of the genus Senecio have been the subject of a large number of phytochemical studies and several biological activities have been demonstrated [7] but the studied species for essential oils constituents are still few and not more than 10 % of the species belonging to this genus [8]. A number of studies have shown that several Senecio species have antimicrobial, antifungal and cytotoxic activities [3].…”

Section: Introductionmentioning

confidence: 99%

“…Many species from Senecio genus have been used in traditional medicine [8,9] and their pharmacological activities have been demonstrated: anti-inflammatory [9], antimicrobial [10] [3, 8, 10], antioxidant activities [3,4,8,11], cytotoxic [8,11] and so on.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, antimicrobial and antioxidant activities of the essential oils from Senecio longiscapus Bojer leaves (Asteraceae)

Herimanana¹,

Nomentsoa²,

Judicaël³

et al. 2021

World J. Bio. Pharm. Health Sci.

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The present work aims to study the chemical composition and the antimicrobial and antioxidant properties of the essential oil of Senecio longiscapus (SLEO) leaves. SLEO was extracted from fresh leaves by hydrodistillation with a yield of 3%. It is clear, yellow, with a relative density of 0.7466 at 20°C, a refractive index of 1.4959, an optical rotation of +3°47, an acid number of 1.53 and an ester number of 12.49. Gas chromatography/mass spectrometry (GC/MS) analysis of the SLEO identified 17 components, representing more than 99.09% of the overall composition. The main component of SLEO was sabinene (53.28%) and elemicin (15%), β-pinene (9.85%), methyleugenol (5.58%), α-pinene (4.84%) and mircene (2.37%) were the major components. At 7.48 mg/disk, SLEO inhibited the growth of all germs tested including four GRAM (+) and five GRAM (-) bacteria and one yeast. The zones of inhibition (ZI) ranged from 12 mm (Yersinia enterolitica) to 40 mm (Bacillus subtilis). The antioxidant activity of SLEO by the DPPH method was IC50 = 4.601 µg/ml. When administered orally at doses as high as 5 g/kg body weight, SLEO was not toxic to mice. Its non-toxicity, antimicrobial and antioxidant activities could make SLEO an alternative in the treatment of infectious diseases.

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Chemical Composition and Biological Activity of Capetula and Shoots Essential Oils of Senecio glaucus L.

Cited by 8 publications

References 52 publications

In Vitro Antioxidant, Cytotoxic Activities, and Phenolic Profile of Senecio glaucus from Saudi Arabia

In Vitro Antioxidant, Cytotoxic Activities, and Phenolic Profile of Senecio glaucus from Saudi Arabia

Profiling Key Aroma Compounds of Senecio glaucus L. and their Antimicrobial and Antioxidant Activities: Multiplex of GC‐MS, NMR and In Silico Studies

Chemical composition, antimicrobial and antioxidant activities of the essential oils from Senecio longiscapus Bojer leaves (Asteraceae)

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