Chemical composition and evaluation of the antibacterial and Cytotoxic activities of the essential oil from the leaves of Myracrodruon urundeuva

Araújo, Ítalo Diego Rebouças de; Aquino, Nayara Coriolano de; Guerra, Andreza Conceição Véras de Aguiar; Júnior, Renato Ferreira de Almeida; Araújo, Renata Mendonça; Júnior, Raimundo Fernandes de Araújo; Farias, Kléber Juvenal Silva; Fernandes, José Veríssimo; Andrade, Vânia Sousa

doi:10.1186/s12906-017-1918-6

Cited by 15 publications

(14 citation statements)

References 65 publications

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“…Identification of proteins exuded from M . urundeuva seeds was performed according to Araújo et al [ 16 ]. SEX, SEXF1, and SEXF2 samples (50 μg) were reduced with dithiothreitol and alkylated with iodoacetamide.…”

Section: Methodsmentioning

confidence: 99%

“…Myracrodruon urundeuva (Portuguese common names: aroeira, aroeira-do-sertão [ 15 ], a tree belonging to the family Anarcadiacea, is highly exploited as a timber source, fuel, and medicinal in the semi-arid northeast region of Brazil. This plant has been noted for its antimicrobial, anti-inflammatory and analgesic properties, anti-leishmania, and larvicidal activity against Aedes aegypti [ 16 – 20 ]. Incidentally, none of these above properties were studied in seed exudates from M .…”

Section: Introductionmentioning

confidence: 99%

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Myracrodruon urundeuva seed exudates proteome and anthelmintic activity against Haemonchus contortus

et al. 2018

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Seed exudates are plant-derived natural bioactive compounds consisting of a complex mixture of organic and inorganic molecules. Plant seed exudates have been poorly studied against parasite nematodes. This study was undertaken to identify proteins in the Myracrodruon urundeuva seed exudates and to assess the anthelmintic activity against Haemonchus contortus, an important parasite of small ruminants. M. urundeuva seed exudates (SEX) was obtained after immersion of seeds in sodium acetate buffer. SEX was fractionated with ammonium sulfate at 0–90% concentration to generate the ressuspended pellet (SEXF1) and the supernatant (SEXF2). SEX, SEXF1, and SEXF2 were exhaustively dialyzed against distilled water (cut-off: 12 kDa) and the protein contents determined. Mass spectrometry analyses of SEX, SEXF1, and SEXF2 were done to identify proteins and secondary metabolites. The seed exudates contained protease, protease inhibitor, peptidase, chitinase, and lipases as well as the low molecular weight secondary compounds ellagic acid and quercetin rhamnoside. SEX inhibited H. contortus larval development (LDA) (IC50 = 0.29 mg mL-1), but did not affect larval exsheathment (LEIA). On the other hand, although SEXF1 and SEXF2 inhibited H. contortus LEIA (IC50 = 1.04 and 0.93 mg mL-1, respectively), they showed even greater inhibition efficiency of H. contortus larval development (IC50 = 0.29 and 0.42 mg mL-1, respectively). To the best of our knowledge, this study is the first to show the anthelmintic activity of plant exudates against a gastrointestinal nematode. Moreover, it suggests the potential of exuded proteins as candidates to negatively interfere with H. contortus life cycle.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Myracrodruon urundeuva seed exudates proteome and anthelmintic activity against Haemonchus contortus

et al. 2018

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“…Essential oils might be used as anticancer agents as found before in Pinus koraiensis against HCT116 colorectal cancer cells [ 28 ], Myracrodruon urundeuva against HeLa, HEK-293, and Vero E6 cells [ 29 ] and Yemeni medicinal plants against A-427, 5637 and MCF-7 cancer cells [ 30 ]. Such activities might be attributed to major essential oil constitutes including cineol, capillin and others [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Effective antioxidant, antimicrobial and anticancer activities of essential oils of horticultural aromatic crops in northern Egypt

Elansary

Abdelgaleil

Mahmoud

et al. 2018

BMC Complement Altern Med

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BackgroundIdentifying ornamental plants as new natural antioxidant and antimicrobial sources is always of great importance for the ornamental and horticultural industries.MethodsThe antimicrobial activities of leaves and fruits peel essential oils of twelve ornamental and horticultural crops were determined by screening against wide spectrum of fungi and bacteria, and their respective in vitro antioxidant capacity was evaluated. Furthermore, the anticancer activities against several cancer cells, and one normal human cell line (HEK-293) were examined.ResultsOriganum vulgare L. essential oil showed the best antioxidant, antibacterial and anticancer activities compared to screened crops by means of the DPPH and linoleic acid assays for antioxidants, MIC and MBC values for antibacterial activities and IC50 for antiproliferative activities. Such important activities in O. vulgare was attributed to high pulegone ratio (77.45%) as revealed by the GC/MS assay. Rosmarinus officinallis L. essential oil showed the highest antifungal activities by means of lowest MIC and MFC values which might be attributed to 1, 8-cineole (19.60%), camphor (17.01%) and α-pinene (15.12%).ConclusionWe suggest that oxygenated monoterpenes (i.e. linalool, terpinen-4-ol and pulegone) and monoterpene hydrocarbons play an important role in the essential oil antioxidant, antibacterial, antifungal and anticancer activities of diverse Egyptian ornamental and horticultural crops. Some species showed bioactivities similar to standards compounds and might be suitable for pharmaceutical and food industries.

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“…Estudos in vitro identificaram diminuição da viabilidade celular dependente da dose em fibroblastos gengivais e células ósseas humanas, interferindo na diferenciação osteogênica e matriz de mineralização, associados à presença de taninos e flavonoides nas folhas de aroeira (Machado et al, 2016b;Matos et al, 2019). Entretanto, Ação antitumoral -Efeitos antitumorais também são atribuídos aos extratos vegetais da planta (Araújo et al, 2017), com ação anti-proliferativa em células leucêmicas (Ferreira et al, 2011) e letalidade acima de 75% para as células tumorais de carcinoma de colon humano, glioblastoma e melanoma (Mahmoud et al, 2011). O composto tephrosin, produzido pelo fungo endofítico Pseudofusicoccum stromaticum, isolado de galhos de M. urundeuva demonstrou atividade contra uma linha celular de câncer colorretal humano (Sobreira et al, 2018).…”

Section: Atividade Biológicaunclassified

“…Os compostos fenólicos desta espécie ainda incluem flavonoides, terpenos, cumarinas, saponinas, xantonas e alcaloides (Carlini et al, 2010;Cecílio et al, 2012;Pinho et al, 2012;Gomes et al, 2013a;Gomes et al, 2013b;Farias et al, 2013;Oliveira et al, 2013a;Oliveira et al, 2017;Figueredo et al, 2014;Vieira et al, 2015;Machado et al, 2016;Galvão et al, 2018;Castro et al, 2020;Cecílio et al, 2016;Araújo et al, 2017;Aquino, Araújo, & Silveira, 2017;Carvalho et al, 2017).…”

Section: Composição Químicaunclassified

Uso, conhecimento e conservação de Myracrodruon urundeuva: uma revisão sistemática

Domingos

Silva

2020

RSD

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Myracrodruon urundeuva, conhecida popularmente como aroeira, é amplamente distribuída no território brasileiro e considerada espécie polivalente por sua diversidade de usos, que incluem aplicações como combustível, madeira, forragem, apicultura, recuperação de áreas e o uso medicinal, muito praticado por populações rurais. Essa diversidade de aplicações pode ameaçar a conservação da espécie devido à exploração excessiva e o uso de técnicas inadequadas que podem resultar em declínio das populações naturais. Com este trabalho, o objetivo foi verificar o conhecimento atual sobre M. urundeuva e seu estado de conservação. Para tanto, foi realizada uma revisão sistemática seguindo o modelo PRISMA, com busca de artigos publicados entre 2010 e 2020. Foram identificados inicialmente 333 artigos, dos quais 165 foram incluídos na revisão. Os artigos se distribuem nas categorias atividade biológica, biologia vegetal e ecologia, composição química, etnobotânica e produção. A maior parte dos estudos diz respeito à avaliação das atividades biológicas da espécie com evidências de efeitos anti-inflamatório, antimicrobiano, antioxidante, antifúngico, antiviral, inseticida e neuroprotetor entre outros, corroborando aplicações terapêuticas da espécie descritas em estudos etnobotânicos. A aroeira não é considerada oficialmente ameaçada de extinção. Embora muitos autores asseverem que a exploração excessiva da espécie seja uma ameaça a sua conservação, não foram encontrados dados que suportem tal suposição. São necessários estudos que avaliem o estado populacional da espécie, a condição ambiental de sua área de distribuição e seu volume de exploração, para que se possa avaliar adequadamente o estado de conservação da espécie e proposição de medidas para seu uso sustentável.

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Chemical composition and evaluation of the antibacterial and Cytotoxic activities of the essential oil from the leaves of Myracrodruon urundeuva

Cited by 15 publications

References 65 publications

Myracrodruon urundeuva seed exudates proteome and anthelmintic activity against Haemonchus contortus

Myracrodruon urundeuva seed exudates proteome and anthelmintic activity against Haemonchus contortus

Effective antioxidant, antimicrobial and anticancer activities of essential oils of horticultural aromatic crops in northern Egypt

Uso, conhecimento e conservação de Myracrodruon urundeuva: uma revisão sistemática

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