Chemical composition and in vitro chemoprevention assessment of Eugenia jambolana Lam. (Myrtaceae) fruits and leaves

Dametto, Alessandra Cristina; Agustoni, Daniele; Moreira, Thaís Fernanda; Plaza, Carenina Vidotte; Prieto, Aline M.; Silva, Tarsia G.A.; Souza, Felipe O.; Boralle, Nivaldo; Sorbo, Juliana Maria; Silva, Dulce Helena Siqueira; Soares, Christiane Pienna

doi:10.1016/j.jff.2017.07.013

Cited by 17 publications

(7 citation statements)

References 38 publications

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“…Their results indicate that H 2 O 2 -induced DNA damage was significantly reduced in cells pretreated with both the tested plant extracts, which were also found to contain phenolic compounds and betulinic acid. Another study examined the effect of a purified Eugenia jambolan leaf and fruit extract on HepG2 cells; the extracts were found to be rich sources of many phenolic compounds and betulinic acid and to exhibit antigenotoxic and antimutagenic effects [53].…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of the DNA-Protective Effects of Extracts fromMenyanthes trifoliataL. Plants Derived fromIn VitroCulture Associated with Redox Balance and Other Biological Activities

Kowalczyk

Sitarek

Skała

et al. 2019

Oxidative Medicine and Cellular Longevity

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Menyanthes trifoliata L. is a valuable medical plant found in Europe, North America, and Asia, which grows on peat bogs and swamps. It has long been used in folk medicine as a remedy for various ailments. This is the first report to demonstrate the protective antioxidant and anti-inflammatory properties of aqueous methanolic extracts derived from the aerial parts (MtAPV) and roots (MtRV) of in vitro grown plants on human umbilical vein endothelial cells (HUVECs). It describes the influence of the tested extracts on the expression of antioxidant (HO-1, NQO1, NRF2, kEAP1, and GCLC) and inflammation-related genes (IL-1α, IL-1β, IL-6, TNF-α, and IFN-γ) in cells stimulated with H2O2 or LPS, respectively. In addition, M. trifoliata extracts were found to moderately affect the growth of certain bacterial and fungal pathogens, with the strongest antibacterial effect found against Pseudomonas aeruginosa and Enterococcus faecalis. M. trifoliata extracts demonstrated protective effects against mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) damage caused by ROS, decreasing the numbers of mtDNA lesions in the ND1 and ND2 genes and nDNA damage in the TP53 and HPRT1 genes and reducing cleavage in PARP1- and γ-H2A.X-positive cells. The root extract of in vitro M. trifoliata (MtRV) appears to have better anti-inflammatory, antioxidant, antimicrobial, and protective properties than the extract from the aerial part (MtAPV). These differences in biological properties may result from the higher content of selected phenolic compounds and betulinic acid in the MtRV than in the MtAPV extract.

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Section: Discussionmentioning

confidence: 99%

An Evaluation of the DNA-Protective Effects of Extracts fromMenyanthes trifoliataL. Plants Derived fromIn VitroCulture Associated with Redox Balance and Other Biological Activities

Kowalczyk

Sitarek

Skała

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…nutraceuticals. The detection of biflavonoids in Garcinia brasiliensis (Arwa et al 2015), gallic acid derivatives in Spondias tuberosa and Inga laurina (Zeraik et al 2016, Falcoski et al 2021, and anthocyanins in Eugenia jambolana (Dametto et al 2017) with chemopreventive activity indicated a promising potential for their sustainable exploration. In addition, the search for value-added products in fruits residues (inedible parts), led to the detection of biflavonoids in Platonia insignis bark and seeds extracts, including the selective extraction of morelloflavone, which has been reported for several important bioactivities, including chemoprevention (Ribeiro et al 2021).…”

Section: Chemical and Biological Studies Regarding Brazilian Flora In...mentioning

confidence: 99%

Bioprospecting as a strategy for conservation and sustainable use of the Brazilian Flora

et al. 2022

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In Brazil, research with natural products had a strong impulse when FAPESP supported the creation of the Laboratory of Chemistry of Natural Products of the Institute of Chemistry of USP (1966). In 1999, FAPESP launched the Research Program in the Characterization, Conservation, Restoration and Sustainable Use of Biodiversity (BIOTA-FAPESP), which intensified the sustainable exploitation of biodiversity, and which evolved to form the Biota Network for Bioprospection and Bioassays (BIOprospecTA), which integrates groups from all over the country, optimizing the use of the skills already installed for the bioprospecting of microorganisms, plants, invertebrates, vertebrates and marine organisms. Of the 104 projects related to plant sciences, 35 carried out bioprospection of Brazilian flora, belonging to the areas of Chemistry, Botany, Genetics, Plant Physiology, Plant Morphology, Plant (Chemo)taxonomy, Ecosystem Ecology, Plant Genetics. Physical Sciences, Forest Resources, Forestry Engineering, Agronomy, leading to thousands of publications, engagement of hundreds of students and a deeper understanding of natural products in different biological models through macromolecules analysis aided by computational and spectrometric strategies, in addition to pharmacological evaluations. The development of omics approaches led to a more comprehensive view of the chemical profile of an organism, and enabled integrated and concomitant studies of several samples, and faster annotation of known molecules, through the use of hyphenated and chemometric techniques, and molecular networking. This also helped to overcome the lack of information on the safety and efficacy of herbal preparations, in projects dealing with the standardization of herbal products, according to international standards. The BIOTA-FAPESP program has also focused on environmental aspects, in accordance with the principles of Green Chemistry and has had positive effects on international collaboration, on the number and impact of scientific publications and on partnership with companies, a crucial step to add value and expand the production chain of bioproducts. Also, the compilation, systematization and sharing of data were contemplated with the creation of the NUBBEDB database, of free access, and that integrates with international databases (ACD/labs, American Chemical Society – ACS), helping researchers and companies in the development from different areas of science, technology, strengthening the bioeconomy and subsidizing public policies.

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“…4,5 Several species are also widely used in ethnomedicine as antihypertensive, antiinflammatory, antidiarrheal agents, and so on. 6,7 Eugenia uniflora L. (Myrtaceae), popularly known as pitanga, is an evergreen shrub native to South America. Its fruits and leaves are widely used as folk medicines to treat fever, diarrhea, rheumatism and diabetes.…”

Section: Introductionmentioning

confidence: 99%

Eugenunilones A–H: rearranged sesquiterpenoids from Eugenia uniflora

Cao

Ang

et al. 2022

Org. Chem. Front.

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Chemical composition and in vitro chemoprevention assessment of Eugenia jambolana Lam. (Myrtaceae) fruits and leaves

Cited by 17 publications

References 38 publications

An Evaluation of the DNA-Protective Effects of Extracts fromMenyanthes trifoliataL. Plants Derived fromIn VitroCulture Associated with Redox Balance and Other Biological Activities

An Evaluation of the DNA-Protective Effects of Extracts fromMenyanthes trifoliataL. Plants Derived fromIn VitroCulture Associated with Redox Balance and Other Biological Activities

Bioprospecting as a strategy for conservation and sustainable use of the Brazilian Flora

Eugenunilones A–H: rearranged sesquiterpenoids from Eugenia uniflora

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