Chemical Composition and In Vitro Antiplasmodial Activity of the Ethanolic Extract of Cyperus articulatus var. nodosus Residue

Assis, Francisco Flávio Vieira de; Silva, Nazaré Carneiro da; Moraes, Waldiney Pires; Barata, Lauro Euclides Soares; Minervino, Antônio Humberto Hamad

doi:10.3390/pathogens9110889

Cited by 10 publications

(12 citation statements)

References 28 publications

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“…Traditional medicine is a cultural practice commonly employed in the Amazon region, relying on the use of medicinal herbs to treat diseases [1,2]. The Amazonian biodiversity comprises a huge reserve of biomolecules with pharmacological potential.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae)

Silva

Barata

Arévalo

et al. 2021

Plants

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Cyperus articulatus L. (Priprioca) is a plant of the Cyperaceae family traditionally used in traditional medicine in the Amazon region. Studies of the essential oil of this species have identified many terpene compounds. However, little is known about the possible uses of solid waste generated by the extraction of essential oils. This study aimed to investigate the chemical composition of volatile compounds and to evaluate the antiproliferative activity of the ethanolic extract of solid residues generated by the extraction of the essential oil of C. articulatus L. rizhomes in experimental models in vitro using peritoneal macrophages of mice and human tumor cell lines. The analysis of the chemical composition of volatile compounds indicated the presence of sesquiterpenes and particularly sequiterpenic ketones as main constituents. The results showed that the treatment with ethanolic extract of C. articulatus L. reduced the activity of the enzyme arginase and proliferation of cancer cells (p < 0.0001). The extract also showed no cytotoxicity in macrophages in concentrations between 12.5; 25 and 50 mg/mL (p < 0.0001). The results indicated that the extract of C. articulatus L. exerts antiproliferative activity (p < 0.0001) with low toxicity on healthy cells in experimental models in vitro.

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Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae)

Silva

Barata

Arévalo

et al. 2021

Plants

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“…Using this method, we found that the hydroalcoholic extract of Jucá presented moderate antiplasmodial activity, with an IC 50 of 11.10 µg/mL against chloroquine-resistant P. falciparum. Working with a different Amazonian plant, Assis et al [33] obtained an IC 50 value of 1.21 µg/mL for the P. falciparum W2 strain using a Cyperus articulatus residue extract. In another study on the same plant (C. articulatus) but using the essential oil, a similar IC 50 was obtained [52].…”

Section: Discussionmentioning

confidence: 99%

“…The hemolytic activity was measured as previously described [33]. Briefly, fresh ethylenediaminetetraacetic acid (EDTA)-containing blood was centrifuged, and a red blood cell (RBC) pellet was washed then resuspended using saline (0.9%) sterile solution to obtain a 2% (v/v) red blood cell solution.…”

Section: Assessment Of Hemolytic Activitymentioning

confidence: 99%

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Antiplasmodial Activity of Hydroalcoholic Extract from Jucá (Libidibia ferrea) Pods

et al. 2023

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Malaria is an infectious and parasitic disease caused by protozoa of the genus Plasmodium, which affects millions of people in tropical and subtropical areas. Recently, there have been multiple reports of drug resistance in Plasmodium populations, leading to the search for potential new active compounds against the parasite. Thus, we aimed to evaluate the in vitro antiplasmodial activity and cytotoxicity of the hydroalcoholic extract of Jucá (Libidibia ferrea) in serial concentrations. Jucá was used in the form of a freeze-dried hydroalcoholic extract. For the cytotoxicity assay, the(3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method with the WI-26VA4 human cell line was used. For the antiplasmodial activity, Plasmodium falciparum synchronized cultures were treated with serial concentrations (0.2 to 50 μg/mL) of the Jucá extract. In terms of the chemical composition of the Jucá extract, gas chromatography coupled to mass spectrometry measurements revealed the main compounds as ellagic acid, valoneic acid dilactone, gallotannin, and gallic acid. The Jucá hydroalcoholic extract did not show cytotoxic activity per MTT, with an IC50 value greater than 100 µg/mL. Regarding the antiplasmodial activity, the Jucá extract presented an IC50 of 11.10 µg/mL with a selective index of nine. Because of its antiplasmodial activity at the tested concentrations and low toxicity, the Jucá extract is presented as a candidate for herbal medicine in the treatment of malaria. To the best of our knowledge, this is the first report of antiplasmodial activity in Jucá.

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“…229 In another study, corymbolone (14.25%), cyclocolorenone (9.75%), cadalene (8.36%), hexadecanoic acid ethyl ester (5.99%), 9-octadecenoic acid ethyl ester (5.5%), cholesta-3,5-diene (4.82%), and cis-thujopsenal (4.19%) were considered most abundant in the rhizome of C. articulatus residue using ethanol as a solvent for extraction. 230 To the best of our knowledge, there is no information in the pharmacopeia showing the anti-RA effect of C. articulatus extract or specific bioactive compound identified in the plant despite anecdotal claims among CAM practitioners and users. However, two active compounds, α-pinene and caryophyllene oxide, have been shown to protect Eugenia aquea and Liquidambaris fructus against adjuvant-induced RA significantly.…”

Section: Indigenous Nigerian Medicinal Plants Whose Bioactive Compoun...mentioning

confidence: 99%

Indigenous Nigeria medicinal herbal remedies: A potential source for therapeutic against rheumatoid arthritis

Arunsi

Chioma

Etusim

et al. 2022

Exp Biol Med (Maywood)

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Rheumatoid arthritis (RA) is a debilitating disease associated with locomotion impairment, and conventional therapeutic drugs are not optimal for managing RA. There is an avalanche of medications used for the management of RA. Still, studies have shown that they are associated with severe side effects, including hepatotoxicity, retinopathy, and cardiotoxicity disorders of the central nervous system (CNS), skin, blood, and infections. Complementary and alternative medicine (CAM) is currently gaining attention as a novel panacea for managing debilitating diseases, such as RA. Nigerian folk herbal remedies are replete with a plethora of curative medicine, albeit unvalidated scientifically but with seemingly miraculous provenance. Studies of the identification of bioactive compounds present in these botanicals using advanced spectral analytical techniques have enhanced our understanding of the role of Nigerian herbal remedies in the treatment and management of RA. Interestingly, experimental studies abound that the bioactive compounds present in the extracts of plant botanicals protected animals from the development of RA in different experimental models and reduced the toxicity associated with conventional therapeutics. Validated mechanisms of RA amelioration in human and animal models include suppression of the expression of NF-κB, IL-1β, TNF-α, IL-6, IL-8, IL-17, IL-23, chemokines, TGF-β, RANKL, RANK, iNOS, arginase, COX-2, VEGFA, VEGFR, NFATC1, and TRAP in the synoviocytes. Decreased ROS, NO, MDA, carbonyl groups, and PGE2 in the synovial fluid increased the expression of PPARα/γ; antioxidant and anti-inflammatory molecules also improve RA etiology. In this mini-review, we discuss the global burden of RA, the novel role of plant-based botanicals as potential therapeutics against signaling pathways in RA. Also addressed is the possible repurposing/reprofiling of plant botanicals to increase their therapeutic index among RA patients that patronize traditional healers in Nigeria with a global projection.

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Chemical Composition and In Vitro Antiplasmodial Activity of the Ethanolic Extract of Cyperus articulatus var. nodosus Residue

Cited by 10 publications

References 28 publications

Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae)

Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae)

Antiplasmodial Activity of Hydroalcoholic Extract from Jucá (Libidibia ferrea) Pods

Indigenous Nigeria medicinal herbal remedies: A potential source for therapeutic against rheumatoid arthritis

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