Chemical composition and pharmacological activity of essential oil of Canarium schweinfurthii

Koudou, Jean; Abena, A. A.; Ngaissona, P.; Bessière, Jean‐Marie

doi:10.1016/j.fitote.2005.06.004

Cited by 69 publications

(49 citation statements)

References 3 publications

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“…The fat content in this fruit is higher than that of avocados (25%) (Hierro et al, 1992) and olives (23%) (Salvador et al, 2001); cf. also our recent study on dabai fatty acid compared with olive and palm oils, Azlan et al, 2010. Previous works on other Canarium species have revealed that Canarium has high antimicrobial activity (Obame et al, 2007), analgesic effects (Koudou et al, 2005) and is rich in oleic and linoleic acids (He and Xia, 2007). At present, the antioxidant properties of C. odontophyllum fruit have not been reported elsewhere.…”

Section: Introductionmentioning

confidence: 91%

Antioxidant capacity of underutilized Malaysian Canarium odontophyllum (dabai) Miq. fruit

Shakirin

Prasad

Ismail

et al. 2010

Journal of Food Composition and Analysis

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Section: Introductionmentioning

confidence: 91%

Antioxidant capacity of underutilized Malaysian Canarium odontophyllum (dabai) Miq. fruit

Shakirin

Prasad

Ismail

et al. 2010

Journal of Food Composition and Analysis

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“…It has been previously shown that nerolidol has antimalarial (Lopes et al, 1999) and antileishmanial activity (Arruda et al, 2005). Moreover, Koudou et al (2005) described that essential oil from Canarium schweinfurthii, which possesses nerolidol as one of the main components, presented antinociceptive activity.…”

Section: Introductionmentioning

confidence: 99%

“…This substance is a sesquiterpene found in many essential oils (Koudou et al, 2005). It has been previously shown that nerolidol has antimalarial (Lopes et al, 1999) and antileishmanial activity (Arruda et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Nerolidol, an Antiulcer Constituent from the Essential Oil of Baccharis dracunculifolia DC (Asteraceae)

Klopell

Lemos

Sousa

et al. 2007

Zeitschrift Für Naturforschung C

123

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In this study, the antiulcerogenic effect of essential oil from Baccharis dracunculifolia was evaluated using the model of acute gastric lesions induced by ethanol. The ulcerative lesion index (ULI) was significantly reduced by oral administration of the essential oil of B. dracunculifolia at doses of 50, 250 and 500 mg/kg which reduced the lesions by 42.79, 45.70 and 61.61%, respectively. The analysis of the chemical composition of the essential oil from B. dracunculifolia by GC showed that this was composed mainly of mono-and sesquiterpenes and the majority compound was nerolidol. Therefore, antiulcerogenic activity of nerolidol (50, 250 and 500 mg/kg) was investigated using ethanol-, indomethacin-and stress-induced ulcer models in rat. In the stress-induced ulcer model, a significant reduction of the ULI in animals treated with nerolidol (50, 250 and 500 mg/kg) and cimetidine (100 mg/kg) was observed, compared to the control group (p Ͻ 0.05). The percentage of inhibition of ulcer was 41.22, 51.31, 56.57 and 53.50% in groups treated with 50, 250, 500 mg/kg of nerolidol and 100 mg/kg of cimetidine (positive control), respectively. Regarding ethanol-and indomethacin-induced ulcer models, it was observed that the treatment with nerolidol (250 and 500 mg/ kg) significantly reduced the ULI in comparison with the control group (p Ͻ 0.05). The dose of 50 mg/kg reduced the parameters analyzed but this was not statistically significant. In the ethanol-induced model percentage of inhibition of ulcer was 34.20, 52.63, 87.63 and 50.87% in groups treated with 50, 250, 500 mg/kg of nerolidol and 30 mg/kg of omeprazol (positive control), respectively. In indomethacin-ulcer the percentage of inhibition of ulcer was 34.69, 40.80, 51.02 and 46.93% in groups treated with 50, 250, 500 mg/kg of nerolidol and 100 mg/ kg of cimetidine (positive control), respectively. The results of this study show that nerolidol displays antiulcer activity, as it significantly inhibited the formation of ulcers induced in different animal models. However, further pharmacological and toxicological investigations, to delineate the mechanism(s) of action and the toxic effects, are required to allow the use of nerolidol for the treatment of gastric ulcer.

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“…In contrast, in Central African Republic, it was described a different chemotype with the dominance of octylacetate (60 %) and nerolidol (14 %) 15 .…”

Section: Resultsmentioning

confidence: 96%

Chemical Investigations of Volatile Oils from Aromatic Plants Growing in Côte d’ivoire:Harisonia abyssinicaOliv.,Canarium schwerfurthiiEngl.Zanthoxylum gilletti(De wild) Waterm. andZanthoxylum zanthoxyloidesLam.

Affouet

Tonzibo

Attioua

et al. 2012

Analytical Chemistry Letters

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This study reports for the first time the results of chemical investigations by GC and GC-MS of the essential oils obtained from different parts of four aromatic plants growing in Côte d'Ivoire, the total among varied from 90.2 % to 98.7 %. The leaves oil of Harrisonia abyssinica was rich in β-caryophyllene (31.2 %), α-humulene (10.3 %) and germacrene D (14.5 %). When, the root bark oil of Canarium shweinfurthii was predominated by δ-2-carene (14.5 %), limonene (20 %) and terpinolene (42.6 %). (E)-β-ocimene (10 %), linalool (49.5 %) and E-nerolidol (11.3 %) constituted the chemotype of stem bark oil of Zanthoxylum gilletti (syn. Zanthoxylum macrophylum), while the leaves oil was rich in (E)-β-ocimene (32.3 %) and linalool (47 %). The leaves oil of Zanthoxylum zanthoxyloides was characterized by myrcene (10 %), germacrene D (10.2 %) accompanied by limonene (7.1 %), β-caryophyllene (7 %) and decanal (6.4 %).

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Chemical composition and pharmacological activity of essential oil of Canarium schweinfurthii

Cited by 69 publications

References 3 publications

Antioxidant capacity of underutilized Malaysian Canarium odontophyllum (dabai) Miq. fruit

Antioxidant capacity of underutilized Malaysian Canarium odontophyllum (dabai) Miq. fruit

Nerolidol, an Antiulcer Constituent from the Essential Oil of Baccharis dracunculifolia DC (Asteraceae)

Chemical Investigations of Volatile Oils from Aromatic Plants Growing in Côte d’ivoire:Harisonia abyssinicaOliv.,Canarium schwerfurthiiEngl.Zanthoxylum gilletti(De wild) Waterm. andZanthoxylum zanthoxyloidesLam.

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