Chemical composition and potential antileishmanial and cytotoxic activity of Duguetia stelechantha (Diels) R.E.Fr. essential oil

Lopes, Auxiliadora Cristina Corrêa Barata; Camara, Marcos Bispo Pinheiro; Lima, Aldilene S.; Nascimento, Matheus Oliveira do; Xavier, Júlia Karla A. M.; Jesus, Caroline M; Mendonça, Cáritas J. S.; Carvalho, André Luís Menezes; Silva, Lucilene A.; Rocha, Cláudia Quintino da

doi:10.1016/j.indcrop.2023.116978

Cited by 1 publication

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“…The α-pinene standard, which is one of the major compounds in EO-PB, was also tested and presented an IC 50 of 64.78 µg/mL. This information was reported in [ 45 ], an additional study conducted by our research group. Samples with IC 50 values equal to or less than 100 μg/mL were defined as active, while samples ranging between 101 and 200 μg/mL were categorized as moderately active, and those over 200 μg/mL were perceived as inactive [ 46 ].…”

Section: Resultsmentioning

confidence: 95%

Chemical Characterization, Leishmanicidal Activity and In Vitro Cytotoxicity of the Essential Oil Extracted from Pectis brevipedunculata (Gardner) Sch.Bip. and Its Incorporation into Microemulsion Systems

Lopes,

do Nascimento,

Camara

et al. 2024

Pharmaceutics

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Pectis brevipedunculata (Gardner) Sch.Bip., known in Brazil as alecrim do campo, is a small Asteraceae family plant with a calming effect and consumed as tea. This species contains components, such as neral and geranial, that display various biological activities, such as leishmanicidal. The aim was to chemically characterize the essential oil (EO) obtained from P. brevipedunculata (EO-PB) by hydrodistillation and a microemulsion formulated with EO (ME-PB), Tween 80 and Transcutol P, assess the leishmanicidal effect against Leishmania (L.) amazonensis promastigotes and cytotoxicity against RAW 264.7. EO-PB and ME-PB were analyzed by Gas Chromatography Mass Spectrometry (GC/MS). Monoterpene hydrocarbons were noteworthy among the identified compounds. The main EO-PB constituents were α-pinene and limonene, followed by neral and geranial, which were maintained in ME-PB. EO-PB presented an inhibitory concentration (IC50) of 20 µg/mL and ME-PB of 0.93 µg/mL. ME-PB inhibition towards the parasite was 20-fold higher than that of EO-PB. This indicated that EO incorporation to the microemulsion resulted in optimized biological activity. Selectivity indices indicate that ME-PB is more selective concerning parasite inhibition. Thus, ME-PB may comprise an adequate approach against Leishmania, as the inhibitory concentration (IC50) promastigotes was lower than that considered toxic for cells cell cytotoxicity of 50% (CC50).

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Section: Resultsmentioning

confidence: 95%