Chemical composition and properties of essential oil  of Ferula foetida (Bunge) Regel growing on Mangyshlak peninsula

Sagyndykova, Meruert; Imanbayeva, Akzhunis; Suleimen, E. M.; Ishmuratova, Margarita

doi:10.31489/2019ch4/25-34

Cited by 5 publications

(4 citation statements)

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“…the family is a promising source of biologically active substances and new highly effective drugs that have a wide range of pharmacological properties. Since ancient times, ferules have been used in folk medicine in various countries (Central Asia, Iran, China, and India) for the treatment of scabies, wounds, tumors, syphilis, tuberculosis, seizures, hysteria, the gastrointestinal tract, and as an antiparasitic remedy [1].…”

Section: Introductionmentioning

confidence: 99%

Coumarins of genus Ferula L. (Apiaceae Lindl.)

Khosnutdinova

Gemejiyeva

Karzhaubekova

et al. 2023

Eurasian Chem.-Technol. J.

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The biologically active coumarins from Ferula L. species of the family Apiaceae Lindl. for the period 1970 to 2022 have been reviewed. The phytochemical investigation of different parts of Ferula L., including gum resin, leaves, fruits, seeds, roots, rhizomes, and resins led to the separation of different types of coumarins. Nearly 185 coumarins were isolated from 35 species of Ferula L. growing in different countries. Coumarins are represented mainly by umbelliferone (7-O-hydroxycoumarin) derivatives substituted in the C-7 position of aglycone, furanocoumarins and metabolites have terpene fragments, esters and glycosides. Umbelliferon is found as a taxon for the genus Ferula L. Some «unusual» metabolites have a furan fragment attached to the pyrone ring. Coumarins are of the psoralen type, containing a furan ring in the C-6 and C-7 positions of the primary skeleton. The rare coumarins with terpene fragments (hemiterpene, monoterpen, sesquiterpene) were reported. The biological activities of some extracts and individual metabolites such as antiinflammatory, cytotoxicity, antibacterial, antileishmanial, antiviral, antigenotoxic, antitumor, anticoagulant, antioxidant, antimycobacterial, inhibition a-glucosidase, antileishmanial were found.

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Section: Introductionmentioning

confidence: 99%

Coumarins of genus Ferula L. (Apiaceae Lindl.)

Khosnutdinova

Gemejiyeva

Karzhaubekova

et al. 2023

Eurasian Chem.-Technol. J.

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“…The phytochemical and biological properties of various plants in Kazakhstan, such as Pulicaria vulgaris [ 3 , 4 ], Ferula spp. [ 5 , 6 ], and Cousinia alata [ 7 , 8 ], have been previously studied. In addition, the essential oils of various plants have been investigated [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Isolation and In Silico Inhibitory Potential against SARS-CoV-2 RNA Polymerase of the Rare Kaempferol 3-O-(6″-O-acetyl)-Glucoside from Calligonum tetrapterum

Suleimen

Jose

Mamytbekova

et al. 2022

Plants

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The phytochemical constituents of Calligonum tetrapterum Jaub. & Spach (Family Polygonaceae) were studied for the first time. The study resulted in the isolation of the rare flavonol glycoside, kaempferol 3-O-(6″-O-acetyl)-glucoside,(K3G-A). The potential inhibitive activity of K3G-A toward SARS-CoV-2 was investigated utilizing several in silico approaches. First, molecular fingerprints and structural similarity experiments were carried out for K3G-A against nine co-crystallized ligands of nine proteins of SARS-CoV-2 to reveal if there is a structural similarity with any of them. The conducted studies showed the high similarity of K3G-A and remdesivir, the co-crystallized ligand of SARS-CoV-2 RNA-dependent RNA polymerase (PDB ID: 7BV2), RdRp. To validate these findings, a DFT study was conducted and confirmed the proposed similarity on the electronic and orbital levels. The binding of K3G-A against RdRp was confirmed through molecular docking studies exhibiting a binding energy of −27.43 kcal/mol, which was higher than that of remdesivir. Moreover, the RdRp-K3G-A complex was subjected to several MD studies at 100 ns that authenticated the accurate mode of binding and the correct dynamic behavior. Finally, in silico ADMET and toxicity evaluation of K3G-A was conducted and denoted the safety and the drug-likeness of K3G-A. In addition to K3G-A, two other metabolites were isolated and identified to be kaempferol (K) and β-sitosterol (β-S).

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“…Traditionally, the oleo‐gum of this plant has a long history of medical use in respiratory diseases including asthma and viral respiratory diseases (Healthcare, 2004). F. foetida oleo‐gum is a rich source of several organic sulfides including thiophenes, disulfides and polysulfide derivatives which gives off a unique garlic‐onion smell (Duan et al, 2002; Khalilova, Bobakulov, Aripova, & Abdullaev, 2013; Sagyndykova, Imanbayeva, Suleimen, & Ishmuratova, 2019). Regarding rational for the use of polysulfide compounds as a kind of H 2 S donors and background of the medicinal application of F. foetida oleo‐gum in viral respiratory diseases, we decided to design a clinical trial on the efficacy of F. foetida oleo‐gum in COVID‐19 treatment.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Covexir® (Ferula foetida oleo‐gum) treatment in symptomatic improvement of patients with mild to moderate COVID‐19: A randomized, double‐blind, placebo‐controlled trial

Hasanpour

Safari

Mohammadpour

et al. 2022

Phytotherapy Research

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The SARS-CoV-2 COVID-19 pandemic has emerged as an unprecedented emergency state in healthcare system and global challenge. In recent decade, the function of exogenous H 2 S in the treatment of respiratory diseases has been investigated using H 2 S-donor agents. Ferula foetida is a medicinal plant that is traditionally used in respiratory diseases including asthma and viral respiratory diseases. The oleo-gum of this plant is a rich source of several organic sulfides including thiophenes, disulfides and polysulfide derivatives, which can act as H 2 S-donor agents. The purpose of this study was to investigate the efficacy of Covexir ® (F. foetida oleo-gum) treatment as a rich source of H 2 S-donor compounds in clinical presentations of patients with COVID-19.The efficacy of Covexir ® was evaluated in a randomized, double-blind, placebocontrolled trial in outpatients with COVID-19. Covexir ® could significantly inhibit cough when compared to the placebo group (p < .01 and p < 001, respectively).Moreover, there was a significant difference (p < 001) between the two groups in dyspnea symptom at follow-up interval of 7 day after receiving Covexir ® . Furthermore, on days 3 and 7, statistically significant differences were observed in myalgia, anorexia, anosmia, and sense of taste severity between two groups. Our findings revealed that Covexir ® was very safe in the treatment of COVID-19 patients with mild to moderate symptoms and it can be recommended to improve clinical presentations of patients with COVID-19 such as cough, shortness of breath, myalgia, anorexia, anosmia, and sense of taste.

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Chemical composition and properties of essential oil of Ferula foetida (Bunge) Regel growing on Mangyshlak peninsula

Cited by 5 publications

References 0 publications

Coumarins of genus Ferula L. (Apiaceae Lindl.)

Coumarins of genus Ferula L. (Apiaceae Lindl.)

Isolation and In Silico Inhibitory Potential against SARS-CoV-2 RNA Polymerase of the Rare Kaempferol 3-O-(6″-O-acetyl)-Glucoside from Calligonum tetrapterum

Efficacy of Covexir® (Ferula foetida oleo‐gum) treatment in symptomatic improvement of patients with mild to moderate COVID‐19: A randomized, double‐blind, placebo‐controlled trial

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