Chemical composition, antibacterial and antioxidant activities of acetone extract from the branches and leaves of Jasminum annamense subsp. annamense (Oleaceae)

Van, Hong Thien; Hung, Ngo Ngoc; Nguyen, Nghia Q.; Pham, Tan‐Viet; Nguyen, Huy H.; Thieu, Gia Linh; Dang, Thi Hoai Thuong; Nguyen, Quoc Hung; Le, Thanh Tho; Le, Van Son; Sao, Đàm

doi:10.25081/jp.2022.v14.7418

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“…1,3-Phenylene, bis(3-phenylpropenoate), identified in the acetone extract of Jasminum annamense subsp. annamense leaves, exerted antioxidant and antibacterial activity [ 51 ]. 1,2:4,5:9,10-Triepoxydecane was extracted from the ethyl acetate fraction of Alysicarpus glumaceus , which had therapeutic properties such as stimulatory, diuretic, antipsychotic, anti-inflammatory, antidiarrheal, abortifacient, antitussive, and anti-asthmatic activity [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Breynia cernua: Chemical Profiling of Volatile Compounds in the Stem Extract and Its Antioxidant, Antibacterial, Antiplasmodial and Anticancer Activity In Vitro and In Silico

et al. 2023

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Breynia cernua has been used as an alternative medicine for wounds, smallpox, cervical cancer, and breast cancer. This plant is a potential source of new plant-derived drugs to cure numerous diseases for its multiple therapeutic functions. An in vitro study revealed that the methanol extract of B. cernua (stem) exhibits antioxidant activity according to DPPH and SOD methods, with IC50 values of 33 and 8.13 ppm, respectively. The extract also exerts antibacterial activity against Staphylococcus aureus with minimum bactericidal concentration of 1875 ppm. Further analysis revealed that the extract with a concentration of 1–2 ppm protects erythrocytes from the ring formation stage of Plasmodium falciparum, while the extract with a concentration of 1600 ppm induced apoptosis in the MCF-7 breast cancer cell line. GC–MS analysis showed 45 bioactive compounds consisting of cyclic, alkyl halide, organosulfur, and organoarsenic compounds. Virtual screening via a blind docking approach was conducted to analyze the binding affinity of each metabolite against various target proteins. The results unveiled that two compounds, namely, N-[β-hydroxy-β-[4-[1-adamantyl-6,8-dichloro]quinolyl]ethyl]piperidine and 1,3-phenylene, bis(3-phenylpropenoate), demonstrated the best binding score toward four tested proteins with a binding affinity varying from −8.3 to −10.8 kcal/mol. Site-specific docking analysis showed that the two compounds showed similar binding energy with native ligands. This finding indicated that the two phenolic compounds could be novel antioxidant, antibacterial, antiplasmodial, and anticancer drugs. A thorough analysis by monitoring drug likeness and pharmacokinetics revealed that almost all the identified compounds can be considered as drugs, and they have good solubility, oral bioavailability, and synthetic accessibility. Altogether, the in vitro and in silico analysis suggested that the extract of B. cernua (stem) contains various compounds that might be correlated with its bioactivities.

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Section: Resultsmentioning

confidence: 99%