Chemical composition, antimicrobial, and cytotoxic properties of five Lamiaceae essential oils

Nikolić, Miloš; Jovanović, Katarina; Marković, Dejan; Marković, Dejan; Gligorijević, Nevenka; Radulović, Siniša; Sokóvić, Marina

doi:10.1016/j.indcrop.2014.07.011

Cited by 111 publications

(95 citation statements)

References 29 publications

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“…The chemical composition of EOs obtained from Thymus species is reported to be comprised of thymol, linalool, geraniol, carvacrol, and p-cymene (Zeljković and Maksimović, 2015). Thymol was found to be a major constituent of S. montana (Nikolić et al, 2014). Thymol, carvacrol and p-cymene were identified as major chemical components of T. zygis and S. montana in our study.…”

Section: Chemical Analyses Of Active Essential Oilsupporting

confidence: 58%

Insecticidal and acetylcholinesterase inhibitory activities of Lamiaceae plant essential oils and their major components against Drosophila suzukii (Diptera: Drosophilidae)

Park

Jang

Yoon

et al. 2016

Industrial Crops and Products

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Section: Chemical Analyses Of Active Essential Oilsupporting

confidence: 58%

Insecticidal and acetylcholinesterase inhibitory activities of Lamiaceae plant essential oils and their major components against Drosophila suzukii (Diptera: Drosophilidae)

Park

Jang

Yoon

et al. 2016

Industrial Crops and Products

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“…Studies with Origanum officinale , a plant in the same family as C. angustifolia , showed high cytotoxicity to MCF‐7 cell lines (IC 50 =8.11 μg mL −1 ), associated with the presence of pulegone in high concentration (77.5 %) in the essential oil . Mentha pulegium essential oil, rich in pulegone (68.7 %), was tested in A549 cell lines by MTT assay, and low cytotoxicity was observed (IC 50 =253.4 μg mL −1 ) after 48 h of treatment, which demonstrated the low activity of the main component to A549 cells and corroborated the results obtained in this study. Essential oils are a very complex mixture and should be considered that also the minor components with high cytotoxic activity identified could contribute to the cytotoxic activity observed.…”

Section: Resultssupporting

confidence: 88%

Cytotoxic Activity of Cunila angustifolia Essential Oil

Sousa

Morgan

Cesca

et al. 2020

Chemistry & Biodiversity

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The Cunila angustifolia essential oil was obtained from fresh leaves by hydrodistillation and analyzed by GC‐FID and GC‐MS to determine its chemical composition. The essential oil presented pulegone (29.5 %) and isomenthol (27.0 %) as major components, and other compounds such as menthone (8.6 %), neomenthol (7.2 %), menthyl acetate (2.5 %) and caryophyllene oxide (2.0 %) were identified. The cytotoxic activity of the essential oil was evaluated by MTS assay, with the human cancer cell lines of the lung (A549), breast (MCF‐7) and skin melanoma (SK‐Mel‐28). The assay showed the highest selectivity, to MCF‐7 cell lines, with IC50 equal to 34.0 μg mL−1, low selectivity for SK‐Mel‐28 cell lines, with IC50 equal to 279.9 μg mL−1, and no mortality to A549 cell lines.

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“…Studies conducted in Bulgaria, Tunisia, Morocco, India, Serbia and Iran, have reported pulegone chemotype but in lower proportions of pulegone compared to the presently studied essential oil [18,[20][21][22][23][24][25]. The high amount of pulegone can be attributed to the harvest area which is located in high altitude.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activity of Mentha Pulegium Essential Oil Against Avian Isolated Esbl Producing Bacteria and Its Synergistic Potential With Antibiotics

Yahiaoui

Benameur

Ben-Mahdi

2017

Int J Pharm Pharm Sci

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Objective: The aim of this study was to evaluate the antibacterial effect of Algerian Mentha pulegium essential oil against extended-spectrum β-lactamases (ESBL) producing bacteria isolated from avian livestock. The synergistic interactions between conventional antibiotics and Mentha pulegium essential oil were assessed. Methods:Essential oil composition was determined by gas chromatograph-flame ionization detector (GC/FID), gas chromatograph-mass spectrometer (GC/MS) analysis.Antibacterial activity of Mentha pulegium essential oil against ESBL producing bacteria was investigated by disc diffusion assay. Minimum inhibitory concentration (MIC) of essential oil and it synergistic interaction with conventional antibiotics were determined by micro-broth dilution method and checkerboard test, respectively. Results:The results indicate that Mentha pulegium essential oil with a high amount of pulegone (88.78%) had high inhibitory activity against the tested strains and particularly displays a satisfactory action against the studied ESBL producing bacteria from animal origin, with a diameter ranging from 13 to 26 mm. Out of 51 combinations tested between essential oil and antibiotics 60.78 % showed total synergy, 13.72 % had presented a partial synergy. The best antibacterial activities were obtained with the combination of Mentha pulegium essential oil and cefazolin, cefotaxime and gentamycin. Conclusion:This study allowed concluding that Mentha pulegium essential oil showed not only satisfactory antibacterial properties, but also acts synergistically combined with conventional antibiotics, which make it a promising alternative to antimicrobial drugs; beside that, it might reduce the minimum effective dose of the drugs which minimizes their possible side effects.

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Chemical composition, antimicrobial, and cytotoxic properties of five Lamiaceae essential oils

Cited by 111 publications

References 29 publications

Insecticidal and acetylcholinesterase inhibitory activities of Lamiaceae plant essential oils and their major components against Drosophila suzukii (Diptera: Drosophilidae)

Insecticidal and acetylcholinesterase inhibitory activities of Lamiaceae plant essential oils and their major components against Drosophila suzukii (Diptera: Drosophilidae)

Cytotoxic Activity of Cunila angustifolia Essential Oil

Antibacterial Activity of Mentha Pulegium Essential Oil Against Avian Isolated Esbl Producing Bacteria and Its Synergistic Potential With Antibiotics

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