Chemical composition, antimicrobial, antioxidant and cytotoxic activity of the essential oil from the leaves of Acanthopanax leucorrhizus (Oliv.) Harms

Hu, Haobin; Zheng, Xudong; Hu, Huaisheng

doi:10.1016/j.etap.2012.07.005

Cited by 17 publications

(11 citation statements)

References 21 publications

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“…A comparison of the inhibitory concentration of 50 with results of previous work shows that the samples have obvious cytotoxic effects at all three steps on both cancer cell lines. [ 26 ] The cytotoxicity of OS and schisandrol A on two cancer cell lines were very similar and were significantly stronger than that of RS from the stems of S. chinensis . This result may be attributed to the lower amount of lignans in RS.…”

Section: Resultsmentioning

confidence: 99%

Isolation and purification of schisandrol A from the stems of Schisandra chinensis and cytotoxicity against human hepatocarcinoma cell lines

Zhu¹,

Li²,

Liu³

et al. 2015

Phcog Mag

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Background:Schisandrol A, a lignan with anticancer effects, is one of the representative components that identifies Schisandra chinensis.Objective:A method for purifying schisandrol A from the stems of S. chinensis was established using an octadecylsilyl (ODS) column combined with preparative high-performance liquid chromatography (HPLC).Materials and Methods:Crude extracts obtained from the stems of S. chinensis using 70% ethanol were separated on an AB-8 macroporous resin column and then eluted with a graded ethanol series. After 70% methanol was used in an ODS column separation, preparative HPLC was used for subsequent purification. The structure was identified by electrospray ionization-mass spectrometry, 1H-nuclear magnetic resonance, and 13C-nuclear magnetic resonance. HepG2 and Bel-7402 hepatocellular carcinoma cell lines were used for toxicological evaluation.Results:21.4 mg of schisandrol A with a purity of 95.2% were collected. The cytotoxicity of the ODS-purified sample and schisandrol A were significantly stronger than that of a resin-purified sample.Conclusion:Schisandrol A was successfully extracted from the stems of S. chinensis and separated with an ODS column combined with preparative HPLC. The samples obtained during the purification process showed different levels of cytotoxicity on the HepG2 and Bel-7402 hepatocellular carcinoma cell lines.

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Section: Resultsmentioning

confidence: 99%

Isolation and purification of schisandrol A from the stems of Schisandra chinensis and cytotoxicity against human hepatocarcinoma cell lines

Zhu¹,

Li²,

Liu³

et al. 2015

Phcog Mag

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“…9 Traditional uses not described in the scientific literature show its ability to disinfect wounds caused by pathogenic fungi of the skin, for this reason a study is proposed that can verify the antifungal potential against dermatophytes, using the essential oils extracted from its leaves, because several species of the Araliaceae family, which contain essential oils, have proven effective as antifungal. [10][11][12] Despite being a medicinal plant frequently used by the ancestral peoples of Ecuador, there are no studies on chemistry and biological activity in the species, therefore this research is an important starting point and opens the possibility of knowing more on the pharmaceutical potential of O. ecuadorensis.…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents and Antifungal Activity of Leaf Essential Oil from Oreopanax ecuadorensis Seem. (Pumamaki), Endemic Plant of Ecuador

Noriega¹,

Vergara²,

Carillo³

et al. 2019

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Background: Oreopanax ecuadorensis Seem. is a plant from Ecuador, that is found in the Andean region of the country. The plant is commonly used in protective rituals, and as an antiflu, analgesic and disinfectant medicine. Aim: The research aims to extract and analyze the chemical composition and evaluation of its antifungal potential of the essential oil extracted from its leaves. Methods: steam distillation was used for the extraction of essential oil, the evaluation of its components was performed by GC/MS, and the antifungal evaluation by the disc diffusion method. Results: The essential oil was obtained with a yield of 0.05%. 33 compounds were detected of which 30 were identified, corresponding to 99.28%; the most abundant molecules were: thujene <α-> (36.63%), followed by bicyclogermacrene with (8.76%), pinene <β-> with (8.32%) and limonene with 5.15%. Three of the four strains evaluated were affected by the oil at concentrations of 1.25%, inhibiting its growth. The strains were: Trichophyton mentagrophytes, Trichophyton rubrum and Microsporum canis. Conclusion: The essential oil shows good antifungal activity, which could be less than 1.25%. In this way, this medicinal plant is valued by verifying ancestral knowledge in the use of medicinal plants by the Andean people of Ecuador.

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“…leucorrhizus possess multiple biological functions such as antibacterial, antioxidant, antitumour and so on, especially its stem barks have been used for a long time to treat rheumatism, numbness, contracture, quadribblelegia, hemiplegia, traumatic injury, edema, and itchy skin . However, up to now, no antitumor component has been isolated from this plant except for a few other ingredients …”

Section: Introductionmentioning

confidence: 99%

“…[2] However, up to now, no antitumor component has been isolated from this plant except for a few other ingredients. [3] [4] Stilbenoids are largely present in nature and have aroused considerable interest for their wide range of bioactivities such as anti-inflammatory, antioxidant, antitumor, antibacterial, antivirus, and neuroprotective effects. [5 -7] Furthermore, the structural modification of natural products is one efficient way to increase their activity and lower the side effect.…”

Section: Introductionmentioning

confidence: 99%

Structural Modification of Stilbenoids from Acanthopanax leucorrhizus and Their Cytotoxic Activity

Liang²,

et al. 2017

Chemistry & Biodiversity

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A new cis-stilbenoid, 1,9-dihydroxy-10-methoxy-6H-dibenzo[b,f]oxocin-6-one (2) was isolated from the AcOEt extract of the stem barks of Acanthopanax leucorrhizus, along with three known stilbenoids, 9-hydroxy-10-methoxy-6H-dibenzo[b,f]oxocin-6-one (1), 5-O-methyl-(E)-resveratrol 3-O-β-d-glucopyranoside (3), and (E)-resveratrol 3-O-β-d-xylopyranoside (4). Two derivatives (2a and 2b) were synthesized by the structural modification of compound 2, which exhibited certain cytotoxic activities against HT-29 and HeLa cell lines in vitro. All compounds were structurally characterized by comprehensive analysis of their spectroscopic data and comparison with literature information, and evaluated for their cytotoxic activities against three human tumor cell lines (HL-60, HT-29, and HeLa) by the standard MTT assay in vitro. The results showed that derivatives 2a and 2b exhibited strong activities than compounds 2 against HT-29 and HeLa cell lines.

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Chemical composition, antimicrobial, antioxidant and cytotoxic activity of the essential oil from the leaves of Acanthopanax leucorrhizus (Oliv.) Harms

Cited by 17 publications

References 21 publications

Isolation and purification of schisandrol A from the stems of Schisandra chinensis and cytotoxicity against human hepatocarcinoma cell lines

Isolation and purification of schisandrol A from the stems of Schisandra chinensis and cytotoxicity against human hepatocarcinoma cell lines

Chemical Constituents and Antifungal Activity of Leaf Essential Oil from Oreopanax ecuadorensis Seem. (Pumamaki), Endemic Plant of Ecuador

Structural Modification of Stilbenoids from Acanthopanax leucorrhizus and Their Cytotoxic Activity

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