Chemical composition, antimicrobial, cytotoxic and antioxidant activities of the essential oil of Artemisia indica Willd

Rashid, Showkat; Rather, Manzoor A.; Shah, Wajaht A.; Bhat, M. Sultan

doi:10.1016/j.foodchem.2012.10.102

Cited by 134 publications

(80 citation statements)

References 23 publications

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“…However, other studies have been done on the cytovtoxicity of the different species of the plant Artemisia. Concentration dependent cytotoxicity of the essential oil of A. indica against four cancer cell lines A-549, THP-1, Caco-2 and HEP-2 has been reported (Rashid et al, 2013). Essential oils of A. absinthium which contained higher amounts of trans-sabinyl acetate and cis/trans-thujones exhibited more toxicity on brine shrimp (Judzentiene et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and Apoptotic Effects of Extracts of Artemisia ciniformis Krasch. & Popov ex Poljakov on K562 and HL-60 Cell Lines

Tayarani‐Najaran

Hajian²,

Mojarrab³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (17), [7055][7056][7057][7058][7059] IntroductionIncrease in prevalence of cancer cases has been associated with the expansion of industrial, chemical and radioactive pollutants, also the gap between human being and nature (Colditz and Wei, 2012; Fasinu and Orisakwe, 2013). Despite the progress in the field of medicinal chemistry and development in the synthesis of several new therapeutic compounds, the role of plants and phytochemicals can not be ignored in pharmaceutical sciences (Cerella et al., 2014). Due to the presence of compounds with cytotoxic and anti-tumor activity in some plants and significant efficacy of plant derived compounds in inhibition and treatment of cancer, as well as the amazing diversity of natural compounds in plants, researches to find new phytochemicals and to evaluate their biological effects is essential and a research priority (Tayarani-Najaran et al., 2011;Wegiera et al., 2012;Sehitoglu et al., 2014).Artemisia is a genus belonging to the family Asteraceae Compositae with commonly fragrant species. Some species such as A. dracunculus L. are kitchen plants and used for

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Section: Discussionmentioning

confidence: 99%

Cytotoxic and Apoptotic Effects of Extracts of Artemisia ciniformis Krasch. & Popov ex Poljakov on K562 and HL-60 Cell Lines

Tayarani‐Najaran

Hajian²,

Mojarrab³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The essential oil extracted from A. indica Willd also exhibited growth inhibition against four cancer cell lines: THP-1 (leukemia), A-549 (lung), HEP-2 (liver), and Caco-2 (colon; Rashid et al 2013). Finally, the ethanolic extract of A. herba-alba reduced the viability of HCT116 colon cancer cells in a dose and time dependent manner (Lupidi et al 2011), and the methanolic extract of this plant showed growth inhibitory effect on RT112 (bladder), Hep2 (larynx), and K562 (leukemia) cell lines in a dose dependent manner (Khlifi et al 2013).…”

Section: Discussionmentioning

confidence: 98%

Genotoxic and cytotoxic effects ofArtemisia herba-albaon mammalian cells

Abderrahman

Shbailat

2014

Caryologia

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Artemisia herba-alba is a medicinal plant that is commonly used in folk remedies in the Middle East. Despite its wide use, little is known about whether or not it is genotoxic and/or cytotoxic to mammalian cells. Here we investigated the genotoxic and cytotoxic effects of the ethanolic plant extract on mice cells at different dose concentrations (125, 250, 375, and 500 μg ml ) and for different exposure times (12, 24, 48, and 72 h). We found that at all exposure times, treatment with high dose concentrations (375 and 500 μg ml ) of A. herba-alba extract significantly reduced cell division in mice bone marrow cells compared to that in the control cells. Also, it induced sister chromatid exchanges and micronuclei formation in bone marrow and peripheral blood cells, respectively. Moreover, high dose concentrations significantly reduced cell viability in bone marrow cell cultures compared to that in the controls. The IC 50 values were 484.38, 513.33, and 490.39 μg ml −1 after 24, 48, and 72 h of exposure, respectively. Our findings reveal that A. herba-alba extract has both genotoxic and cytotoxic effects on mammalian cells, particularly at high concentrations. Therefore, we suggest that the plant extract should not be used at high concentrations in folk medicine.

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“…The conducted study on ethanol extract of Artemisia seeds in Nigeria showed that the level of IC 50 was 150.33 ± 1.5 µg per mL (27).…”

Section: Discussionmentioning

confidence: 98%

Artemisia spicigera Essential Oil: Assessment of Phytochemical and Antioxidant Properties

ghajarbeygi¹,

Mohammadi²,

Mahmoudi³

et al. 2015

Biotech Health Sci

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Background: Essential oils (EO), also called volatile odoriferous oil, are aromatic oily liquids extracted from different parts of plants.In general, the constituents in EOs are terpenes, aromatic compounds (aldehyde, alcohol, phenol, methoxy derivatives, and so on), and terpenoids (isoprenoids). Essential Oils have been known to possess antioxidant and antimicrobial activities, thereby serving as natural additives in foods and food products. Objectives: The aim of this study was to assess the quantity and quality of compounds, with active chemical and antioxidant properties, of Artemisia spicigera essential oil (EO) due to the effect of geographic location and season of harvest on the phenolic compounds of the plant. The plant was collected from east Azarbayjan province, Iran (both before and after the flowering stage). Materials and Methods: A. spicigera EO was analyzed by gas chromatogram/mass spectrometry (GC-MS). The antioxidant activity and total phenolic content before and after flowering were evaluated by the Folin Ciocalteu method. Also, the yields of essential oil as a percentage based on the level of dry plant and the volume of extracted oil was determined. Results: Analysis of A. spicigera EO by gas chromatogram-mass spectrometry showed that spachulenol 1 H cycloprop (18.39%) and bicyclo hexan-3-en, 4-met (26.16%), were the prominent EOs of Artemisia before and after the flowering stage; the total phenolic EO before and after the flowering stage was 23.61 ± 1.08 µg/mL and 17.71 ± 0.9 µg/mL, respectively. Also level of flavonoid content before and after the flowering stage was 37.27 ± 1.70 µg/mL and 29.04 ± 1.30 µg/mL, respectively. This EO was able to reduce the stable free radical 2, 2-diphenol,1-picryl hydrazyl (DPPH) with an IC 50 of 86.14 ± 2.23 and 96.18 ± 2.61 µg/mL, before and after flowering, respectively. Yield of EO before and after flowering was 0.5% and 0.6%, respectively. Conclusions: Results have shown that A. spicigera EO before and after flowering has antioxidant properties and therefore can be used in combination with other preservatives to protect food materials against a variety of oxidative systems.

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Chemical composition, antimicrobial, cytotoxic and antioxidant activities of the essential oil of Artemisia indica Willd

Cited by 134 publications

References 23 publications

Cytotoxic and Apoptotic Effects of Extracts of Artemisia ciniformis Krasch. & Popov ex Poljakov on K562 and HL-60 Cell Lines

Cytotoxic and Apoptotic Effects of Extracts of Artemisia ciniformis Krasch. & Popov ex Poljakov on K562 and HL-60 Cell Lines

Genotoxic and cytotoxic effects ofArtemisia herba-albaon mammalian cells

Artemisia spicigera Essential Oil: Assessment of Phytochemical and Antioxidant Properties

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