Chemical composition, antioxidant and antibacterial activities and evaluation of cytotoxicity of the fractions obtained from<i>Selaginella convoluta</i>(Arn.) Spring (Selaginellaceae)

Macêdo, Larissa Alves Ribeiro de Oliveira; Oliveira-Júnior, Raimundo Gonçalves de; Souza, Grasielly Rocha; Oliveira, Ana Paula de; Lavor, Érica Martins de; Silva, Mariana Gama e; Pacheco, Alessandra Gomes Marques; Menezes, Irwin Rose Alencar de; Coutinho, Henrique Douglas Melo; Pessoa, Cláudia; Costa, Marcília Pinheiro da; Almeida, Jackson Roberto Guedes da Silva

doi:10.1080/13102818.2018.1431055

Cited by 17 publications

(10 citation statements)

References 45 publications

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“…S. inaequalifolia showed good antagonistic activity against S. aureus , E. coli and C. albicans [ 27 ]. S. convoluta showed significant antibacterial potential against B. cereus , E. coli , S. enterica , S. marcescens , K. pneumoniae , S. flexneri , E. faecalis and S. aureus [ 28 ]. S. tamariscina is known to possess potent activity against oral bacterial pathogens such as P. gingivalis , P. intermedia , S. mutans , S. sobrinus , S. gordonii , F. nucleatum , S. sanguinis , S. anginosus , S. ratti , A. actinomycetemcomitans , S. parasanguinis , S. criceti and S. downei [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Phytochemistry, Bioactivities, Pharmacokinetics and Toxicity Prediction of Selaginella repanda with Its Anticancer Potential against Human Lung, Breast and Colorectal Carcinoma Cell Lines

et al. 2021

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In this study, we investigated the bioactive potential (antibacterial and antioxidant), anticancer activity and detailed phytochemical analysis of Selaginellarepanda (S. repanda) ethanolic crude extract for the very first time using different in vitro approaches. Furthermore, computer-aided prediction of pharmacokinetic properties and safety profile of the identified phytoconstituents were also employed in order to provide some useful insights for drug discovery. S. repanda, which is a rich source of potent natural bioactive compounds, showed promising antibacterial activity against the tested pathogenic bacteria (S. aureus, P. aeruginosa, E. coli and S. flexneri). The crude extract displayed favorable antioxidant activity against both 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50 = 231.6 μg/mL) and H2O2 (IC50 = 288.3 μg/mL) molecules. S. repanda also showed favorable and effective anticancer activity against all three malignant cancer cells in a dose/time dependent manner. Higher activity was found against lung (A549) (IC50 = 341.1 μg/mL), followed by colon (HCT-116) (IC50 = 378.8 μg/mL) and breast (MCF-7) (IC50 = 428.3 μg/mL) cancer cells. High resolution-liquid chromatography–mass spectrometry (HR-LC–MS) data of S. repanda crude extract revealed the presence of diverse bioactive/chemical components, including fatty acids, alcohol, sugar, flavonoids, alkaloids, terpenoids, coumarins and phenolics, which can be the basis and major cause for its bioactive potential. Therefore, achieved results from this study confirmed the efficacy of S. repanda and a prospective source of naturally active biomolecules with antibacterial, antioxidant and anticancer potential. These phytocompounds alone with their favorable pharmacokinetics profile suggests good lead and efficiency of S. repanda with no toxicity risks. Finally, further in vivo experimental investigations can be promoted as probable candidates for various therapeutic functions, drug discovery and development.

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Section: Resultsmentioning

confidence: 99%

Phytochemistry, Bioactivities, Pharmacokinetics and Toxicity Prediction of Selaginella repanda with Its Anticancer Potential against Human Lung, Breast and Colorectal Carcinoma Cell Lines

et al. 2021

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“…The aromatic benzene rings with substituted hydroxyl groups are responsible for their biological activity through the capacity to eliminate or absorb free radicals, and to chelate reactive oxygen species molecules formators. Furthermore, the effectiveness is generally proportional to the number of hydroxyl (OH) groups present in their aromatic rings 51 . phenols content.…”

Section: Chlorophyll Quantification Leaves Ofmentioning

confidence: 99%

Phytochemical analysis and biological activities of in vitro cultured Nidularium procerum, a bromeliad vulnerable to extinction

Gollo

Tanobe

Pereira

et al. 2020

Sci Rep

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In this study, Response surface methodology (RSM) was applied to optimize the yield of crude methanolic extract of Mitragyna speciosa leaves using Ultrasound-assisted extraction (UAE). The crude methanolic extract and its fractions were quanti ed in terms of total phenolic content and total avonoid content, along with characterized using Fourier-transform infrared and Gas chromatography-mass spectrometry. The results showed the maximum yield of 49.72% at the optimal conditions (temperature, 34 °C; time, 25 min; and volume of solvent, 166 mL). The recovery crude methanolic extract for TPC and TFC were 137.3 ± 15.7 mg GAE/g and 90.3 ± 15.3 mg RE/g, respectively.

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“…The first mentioned correlation showed no hit with a significance ≤ 0.05, which is in agreement with the additive/synergistic mode of action of compounds in such complex matrixes as plant crude extracts [ 45 ]. The antioxidant activity of flavonoids is well known for flavonoids isolated from Selaginella species [ 46 ], but the antioxidant activity of (neo)lignans [ 47 ] and selaginellins [ 33 ] has not been verified yet. However, it has to be mentioned that biochemical assays have their limitations—they omit such important parameters as compound availability, first-pass metabolism, ability to cross the membranes, etc.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Chemical Composition and Biological Activities of Eight Selaginella Species

et al. 2020

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Selaginella P. Beauv. is a group of vascular plants in the family Selaginellaceae Willk., found worldwide and numbering more than 700 species, with some used as foods and medicines. The aim of this paper was to compare methanolic (MeOH) and dichloromethane (DCM) extracts of eight Selaginella species on the basis of their composition and biological activities. Six of these Selaginella species are underinvestigated. Using ultra-high performance liquid chromatography–high-resolution mass spectrometry (UHPLC–HRMS) analysis, we identified a total of 193 compounds among the tested Selaginella species, with flavonoids predominating. MeOH extracts recovered more constituents that were detected, including selaginellins, the occurrence of which is only typical for this plant genus. Of all the tested species, Selaginellaapoda contained the highest number of identified selaginellins. The majority of the compounds were identified in S. apoda, the fewest compounds in Selaginellacupressina. All the tested species demonstrated antioxidant activity using oxygen radical absorption capacity (ORAC) assay, which showed that MeOH extracts had higher antioxidant capacity, with the half maximal effective concentration (EC50) ranging from 12 ± 1 (Selaginellamyosuroides) to 124 ± 2 (Selaginellacupressina) mg/L. The antioxidant capacity was presumed to be correlated with the content of flavonoids, (neo)lignans, and selaginellins. Inhibition of acetylcholinesterase (AChE) was mostly discerned in DCM extracts and was only exhibited in S. myosuroides, S. cupressina, Selaginellabiformis, and S. apoda extracts with the half maximal inhibitory concentration (IC50) in the range of 19 ± 3 to 62 ± 1 mg/L. Substantial cytotoxicity against cancer cell lines was demonstrated by the MeOH extract of S. apoda, where the ratio of the IC50 HEK (human embryonic kidney) to IC50 HepG2 (hepatocellular carcinoma) was 7.9 ± 0.2. MeOH extracts inhibited the production of nitrate oxide and cytokines in a dose-dependent manner. Notably, S. biformis halved the production of NO, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 at the following concentrations: 105 ± 9, 11 ± 1, and 10 ± 1 mg/L, respectively. Our data confirmed that extracts from Selaginella species exhibited cytotoxicity against cancer cell lines and AChE inhibition. The activity observed in S. apoda was the most promising and is worth further exploration.

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Chemical composition, antioxidant and antibacterial activities and evaluation of cytotoxicity of the fractions obtained fromSelaginella convoluta(Arn.) Spring (Selaginellaceae)

Cited by 17 publications

References 45 publications

Phytochemistry, Bioactivities, Pharmacokinetics and Toxicity Prediction of Selaginella repanda with Its Anticancer Potential against Human Lung, Breast and Colorectal Carcinoma Cell Lines

Phytochemistry, Bioactivities, Pharmacokinetics and Toxicity Prediction of Selaginella repanda with Its Anticancer Potential against Human Lung, Breast and Colorectal Carcinoma Cell Lines

Phytochemical analysis and biological activities of in vitro cultured Nidularium procerum, a bromeliad vulnerable to extinction

Comparison of Chemical Composition and Biological Activities of Eight Selaginella Species

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