Chemical composition, antioxidant and antimicrobial potential of essential oils from different parts of Daphne mucronata Royle

Abstract

This research work was executed to determine chemical composition, anti-oxidant and anti-microbial potential of the essential oils extracted from the leaves and stem of Daphne mucronata Royle. From leaves and stem oils fifty-one different constituents were identified through GC/MS examination. The antioxidant potential evaluated through DPPH free radical scavenging activity and %-inhibition of peroxidation in linoleic acid system. The stem’s essential oil showed the good antioxidant activity as compared to leaves essential oil. Results of Antimicrobial activity revealed that both stem and leaves oils showed strong activity against Candida albicans with large inhibition zone (22.2 ± 0.01, 18.9 ± 0.20 mm) and lowest MIC values (0.98 ± 0.005, 2.44 ± 0.002 mg/mL) respectively. Leaves essential was also active against Escherichia coli with inhibition zone of 8.88 ± 0.01 mm and MIC values of 11.2 ± 0.40 mg/mL. These results suggested that the plant’s essential oils would be a potential cradle for the natural product based antimicrobial as well as antioxidant agents.

Antiproliferative Role of Secondary Metabolites From Aspergillus unguis AG 1.1 (G) Isolated From Marine Macroalgae Enteromorpha sp. by Inducing Intracellular ROS Production and Mitochondrial Membrane Potential Loss Leading to Apoptosis

“…A critical observation was the presence of a major peak of an unknown compound. Octadecanoid acid and hexadecenoic acid exhibit antiproliferative activity, antioxidant activity, and anti-microbial activities (Habib et al, 1987;Ravi and Krishnan, 2017;Ashraf et al, 2018). In our study, the presence of above-mentioned fatty acids in A. unguis mycelium could be greatly contributing to its antioxidant activity.…”

Phytochemical profiling and antioxidant potential of Daphne mucronata Royle and action against paracetamol-induced hepatotoxicity and nephrotoxicity in rabbits

“…In the current study HPLC profiling of D. mucronata leaf extract showed the presence of phenolic and flavonoid compounds like malic acid, gallic acid, chlorogenic acid, epigallocatechin gallate, quercetin, morin, ellagic acid, and rutin. Among them, chlorogenic acid, epigallocatechin gallate, quercetin, and ellagic acid have previously exhibited strong antioxidant and hepatoprotective activities ( Zhang et al, 2014 , Afifi et al, 2018 , Ashraf et al, 2018 , Aljelehawy et al, 2020 ). Plants have antioxidant properties depending on the content of phenol and flavonoids, due to which they may play a role in scavenging free radicals thus exhibiting protective effects in oxidative stress and related complications in animal models ( Nazir et al, 2021 ).…”

GC-MS Analysis of Potentially Volatile Compounds of Pleurotus ostreatus Polar Extract: In vitro Antimicrobial, Cytotoxic, Immunomodulatory, and Antioxidant Activities

“…According to Dkhil et al (2020), HPLC analysis of P. ostreatus polar extract detected certain phenolics, including chlorogenic acid, that had antioxidant properties. Secondary metabolites and bioactive compounds identified by GC/MS in various mushroom and plants have previously been reported to have antimicrobial, anti-inflammatory, antioxidant, and antiproliferative activities (Riaz et al, 2012;Rizwan et al, 2012;Ashraf et al, 2014Ashraf et al, , 2018Imran et al, 2014;Zubair et al, 2017;Majeed et al, 2021;Venturella et al, 2021). Therefore, the volatile bioactive components found P. ostreatus fruiting body polar extract may play important roles in the studied biological properties.…”