Chemical composition, antioxidant, anti-melanogenic and anti-inflammatory activities of Glechoma hederacea (Lamiaceae) essential oil

Chou, Su‐Tze; Lai, Chin-Chun; Lai, Chia-Pei; Chao, Wen-Wan

doi:10.1016/j.indcrop.2018.06.032

Cited by 41 publications

(32 citation statements)

References 64 publications

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“…Essential oils can thus act in two ways: by neutralizing free radicals (the antioxidant effect) and as anti-inflammatory agents by inhibiting the release of pro-inflammatory mediators. [7] Secondary metabolites produced by plants are also capable of acting in a third way, as antifungal agents. Such substances can aid in wound healing and decrease symptoms in patients affected by dermatophytosis.…”

Section: Introductionmentioning

confidence: 99%

Antichemotactic and Antifungal Action of the Essential Oils from Cryptocarya aschersoniana, Schinus terebinthifolia, and Cinnamomum amoenum

Maciel

Lacerda

Danielli

et al. 2019

Chemistry & Biodiversity

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The purpose of this work was to determine the chemical composition and evaluate the antichemotactic, antioxidant, and antifungal activities of the essential oil obtained from the species Cryptocarya aschersoniana Mez, Cinnamomum amoenum (Ness & Mart.) Kosterm., and Schinus terebinthifolia Raddi, as well as the combination of C. aschersoniana essential oil and terbinafine against isolates of dermatophytes. Allo‐aromadendrene, bicyclogermacrene, and germacrene B were identified as major compounds in essential oils. The essential oil of C. aschersoniana shown 100 % inhibitory effect on leukocyte migration at the concentration of 10 μg/mL while S. terebinthifolia oil presented 80.1 % inhibitory effect at the same concentration. Only S. terebinthifolia oil possessed free‐radical‐scavenging activity which indicates its antioxidant capacity. The essential oils were also tested against fungal isolates of dermatophyte species (Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis and Microsporum gypseum), resulting in MIC ranging from 125 μg/mL to over 500 μg/mL. C. aschersoniana oil combined with terbinafine resulted in an additive interaction effect. In this case, the essential oil may act as a complement to conventional therapy for the topical treatment of superficial fungal infections, mainly because it is associated with an anti‐inflammatory effect.

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Section: Introductionmentioning

confidence: 99%

Antichemotactic and Antifungal Action of the Essential Oils from Cryptocarya aschersoniana, Schinus terebinthifolia, and Cinnamomum amoenum

Maciel

Lacerda

Danielli

et al. 2019

Chemistry & Biodiversity

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“…Our study indicated that rosmarinic acid, chlorogenic acid, caffeic acid, rutin, genistin, and ferulic acid were the most abundant phytochemicals in HWG and possess potent antioxidant and anti-in ammatory properties [15]. Supporting evidence indicated that G. hederacea extracts possess various biological activities including depigmentation, anti-melanogenic, antitumor, antioxidative, hepatoprotective, and anti-in ammatory activity [16][17][18][19][20].…”

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confidence: 64%

Bidirect effects from cisplatin combine with rosmarinic acid (RA) or hot water extracts of Glechoma hederacea (HWG) on renal cancer cells

Chou

Tai

et al. 2020

Preprint

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Abstract Background: Cisplatin (CDDP) is a chemotherapeutic drug which also causes adverse side effects. Glechoma hederacea is a traditional Chinese herb belonging to the Labiatae family and has many biological activities. Our previous study indicated that rosmarinic acid (RA) was the most abundant phytochemical in G. hederacea. However, the antioxidant or anti-inflammatory effects of the combined treatment of G. hederacea, RA and CDDP on human renal cell carcinoma (RCC) 786-O cells have not been clearly demonstrated. We aimed to investigate the bioefficacy of hot water extracts of G. hederacea (HWG) and RA in inhibiting RCC 786-O cell activity and its synergism with CDDP against metastatic renal cancer cell. Methods: Bioactivities of the combination treatment of HWG, RA, HWG/CDDP and RA/CDDP were assessed using the MTT assay and transwell migration, and the crude extract/compound efficacy was evaluated using wound healing migration assays, flow cytometry and western blotting. Results: Our study indicates that CDDP inhibits 786-O cell proliferation and migration and HWG and RA protect against these effects. On the other hand, HWG and RA demonstrate a low cytotoxic effect in human renal proximal tubular epithelial cell line -2 (HK-2 cells). Cell cycle analysis found that HWG/CDDP and RA/CDDP combined treatment exerted cytotoxicity by inducing G2/M arrest and apoptosis. RA in combined with CDDP significantly inhibiting the expression of p-FAK (Tyr 925) in RCC 786-O cells in vitro.Conclusion: We propose that the inhibition of RA on RCC 786-O cell invasion and migration may partly occur through the downregulation of FAK phosphorylation. The HWG/CDDP and RA/CDDP combined treatments may be effective strategies for intervention of RCC 786-O cell activity.

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“…Table 6 shows studies in which the antioxidant effects of EOs and their components have been analyzed using cell-free assays or melanoma models. Artemisia argyi -DPPH, ABTS, metal-ion chelation [28] Atriplex undulata -Crocin bleaching inhibition, DPPH [29] Cinnamomum cassia Cinnamaldehyde B16 [32] Chrysanthemum boreale Makino -DPPH, ABTS [31] Cryptomeria japonica -B16 [220] Cuminum Cyminum -DPPH, superoxide anion radical-scavenging activity, β-carotene/linoleic acid [35] Curcuma aromatica -DPPH [36] Curcuma kwangsiensis -DPPH [37] Dalbergia pinnata -DPPH, ABTS [39] Eucalyptus camaldulensis -DPPH, ABTS, B16-F10 [41] Eugenia uniflora -DPPH, β-carotene/linoleic acid [43] Glechoma hederacea β-carotene/linoleic acid, B16 [44] Helichrysum microphyllum -DPPH, ABTS [45] Hypericum hircinum -DPPH, ABTS [47] Lavandula augustifolia -B16-F10 [49] Melaleuca quinquenervia 1,8-Cineole, α-pipene, α-terpineol B16 [53] Ocimum basilicum -DPPH, hypoxanthine/xanthine oxidase [58] Ocimum gratissimum -DPPH, hypoxanthine/xanthine oxidase [58,237] Ocimum micranthum -DPPH, hypoxanthine/xanthine oxidase [58] Ocimum tenuiflorum -DPPH, hypoxanthine/xanthine oxidase [58] Table 6. Cont.…”

Section: Chemopreventive Activitymentioning

confidence: 99%

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Martile

Garzoli

Ragno

et al. 2020

Cancers

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The last two decades have seen the development of effective therapies, which have saved the lives of a large number of melanoma patients. However, therapeutic options are still limited for patients without BRAF mutations or in relapse from current treatments, and severe side effects often occur during therapy. Thus, additional insights to improve treatment efficacy with the aim to decrease the likelihood of chemoresistance, as well as reducing side effects of current therapies, are required. Natural products offer great opportunities for the discovery of antineoplastic drugs, and still represent a useful source of novel molecules. Among them, essential oils, representing the volatile fraction of aromatic plants, are always being actively investigated by several research groups and show promising biological activities for their use as complementary or alternative medicine for several diseases, including cancer. In this review, we focused on studies reporting the mechanism through which essential oils exert antitumor action in preclinical wild type or mutant BRAF melanoma models. We also discussed the latest use of essential oils in improving cancer patients’ quality of life. As evidenced by the many studies listed in this review, through their effect on apoptosis and tumor progression-associated properties, essential oils can therefore be considered as potential natural pharmaceutical resources for cancer management.

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Chemical composition, antioxidant, anti-melanogenic and anti-inflammatory activities of Glechoma hederacea (Lamiaceae) essential oil

Cited by 41 publications

References 64 publications

Antichemotactic and Antifungal Action of the Essential Oils from Cryptocarya aschersoniana, Schinus terebinthifolia, and Cinnamomum amoenum

Antichemotactic and Antifungal Action of the Essential Oils from Cryptocarya aschersoniana, Schinus terebinthifolia, and Cinnamomum amoenum

Bidirect effects from cisplatin combine with rosmarinic acid (RA) or hot water extracts of Glechoma hederacea (HWG) on renal cancer cells

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

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