Chemical Composition, Antiviral and Cytotoxic Activities of Essential Oil from<i>Cyperus rotundus</i>Growing in Egypt: Evidence from Chemometrics Analysis

Samra, Reham M.; Soliman, Amal F.; Zaki, Ahmed A.; El-Gendy, Abdel Nasser G.; Hassan, Madiha; Zaghloul, Ahmed

doi:10.1080/0972060x.2020.1823892

Cited by 12 publications

(10 citation statements)

References 22 publications

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“…Literature showed that some plant EOs can inhibit CVB [45]. As EOs are complex mixtures, the antiCV-B activity can be due to the major or minor compounds or to their combination.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxicity and Antiviral Activities of Haplophyllum tuberculatum Essential Oils, Pure Compounds, and Their Combinations against Coxsackievirus B3 and B4

et al. 2021

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Haplophyllum tuberculatum is a plant commonly used in folk medicine to treat several diseases including vomiting, nausea, infections, rheumatism, and gastric pains. In the current study, H. tuberculatum essential oils, hydrosols, the pure compounds R-(+)-limonene, S-(−)-limonene, and 1-octanol, as well as their combinations R-(+)-limonene/1-octanol and S-(−)-limonene/1-octanol, were screened for their cytotoxicity on HEp-2 cells after 24, 48, and 72 h, and then tested for their activity against Coxsackievirus B3 and B4 (CV-B3 and CV-B4) at 3 different moments: addition of the plant compounds before, after, or together with virus inoculation. Results showed that the samples were more cytotoxic after 72 h than after 24 h or 48 h cell contact. However, the combinations R-(+)-limonene/1-octanol and S-(−)-limonene/1-octanol showed less effect on HEp-2 cells than pure R-(+)-limonene and S-(−)-limonene after 24 h, 48 h, and 72 h. 1-octanol exhibited the highest concentration causing 50% cytotoxicity (CC50) on HEp-2 cells after 24 h (CC50 = 93 µg/mL) and 48 h (CC50 = 83 µg/mL). The antiviral assays showed that the tested samples exhibited potent inhibition of CV-B. IC50 values ranged from 0.66 µg/mL to 28.4 µg/mL. In addition, CV-B3 was more sensitive than CV-B4. Both CV-B strains are more inhibited when cells were pretreated with the plant compounds. The hydrosols have no effect, neither on HEp-2 cells nor on the virus. 1-octanol, S-(−), and R-(+)-limonene/1-octanol had important selectivity indexes over time. Although essential oils had potent antiviral activity, they can be considered for application in the pretreatment of cells. However, 1-octanol and the combinations are within the safety limits, and thus, they can be used as an active natural antiviral agent for CV-B3 and CV-B4 inhibition.

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“…Literature showed that some plant EOs can inhibit CVB [45]. As EOs are complex mixtures, the antiCV-B activity can be due to the major or minor compounds or to their combination.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxicity and Antiviral Activities of Haplophyllum tuberculatum Essential Oils, Pure Compounds, and Their Combinations against Coxsackievirus B3 and B4

et al. 2021

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“…A study demonstrated that essential oil extracted from the rhizomes of this plant has inhibitory activity against HAV, HSV-I, and CVB. Humulene epoxide and caryophyllene oxide were identified as major bioactive compounds from this essential oil ( Samra et al, 2020 ). Caryophyllene oxide has been reported to exhibit very potent inhibitory activity against HSV-I which might be a prime lead for development of topical therapeutic agent to treat recurrent infection caused by HSV-I ( Astani et al, 2011 ).…”

Section: Antiviral Plants Of Bangladeshmentioning

confidence: 99%

A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV

et al. 2021

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Currently, viral infection is the most serious health issue which causing unexpected higher rate of death globally. Many viruses are not yet curable, such as corona virus-2 (SARS-CoV-2), human immunodeficiency virus (HIV), hepatitis virus, human papilloma virus and so others. Furthermore, the toxicities and ineffective responses to resistant strains of synthetic antiviral drugs have reinforced the search of effective and alternative treatment options, such as plant-derived antiviral drug molecules. Therefore, in the present review, an attempt has been taken to summarize the medicinal plants reported for exhibiting antiviral activities available in Bangladesh along with discussing the mechanistic insights into their bioactive components against three most hazardous viruses, namely SARS-CoV-2, HIV, and HBV. The review covers 46 medicinal plants with antiviral activity from 25 families. Among the reported 79 bioactive compounds having antiviral activities isolated from these plants, about 37 of them have been reported for significant activities against varieties of viruses. Hesperidin, apigenin, luteolin, seselin, 6-gingerol, humulene epoxide, quercetin, kaempferol, curcumin, and epigallocatechin-3-gallate (EGCG) have been reported to inhibit multiple molecular targets of SARS-CoV-2 viral replication in a number of in silico investigations. Besides, numerous in silico, in vitro, and in vivo bioassays have been demonstrated that EGCG, anolignan-A, and B, ajoene, curcumin, and oleanolic acid exhibit anti-HIV activity while piperine, ursolic acid, oleanolic acid, (+)-cycloolivil-4′-O-β-d-glucopyranoside, quercetin, EGCG, kaempferol, aloin, apigenin, rosmarinic acid, andrographolide, and hesperidin possess anti-HBV activity. Thus, the antiviral medicinal plants and the isolated bioactive compounds may be considered for further advanced investigations with the aim of the development of effective and affordable antiviral drugs.

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“…Unlike synthetic drugs, most of the EOs are non-toxic and listed as generally regarded as safe (GRAS) by U. S. Food and Drug Administration (FDA). Many researchers have begun to explore the effect and efficacy of EOs against various infectious, acute, and chronic diseases [ [25]∗∗ , [26]∗ , [27] , [28] ].…”

Section: Emulsion Components Delivering Antiviral Activitymentioning

confidence: 99%

Section: Emulsion Components Delivering Antiviral Activitymentioning

confidence: 99%

“…The in vitro evaluation of camphor comprising EOs of Chrysanthemum indicum (36.69%) and C. morifolium (14.56%) [ 25 ], and the humulene epoxide and caryophyllene oxide constituting EO of Egyptian Cyperus rotundus rhizomes (38.43 and 21.03%) [ 26 ] displayed dose-dependent inhibitory effect against HSV-1 and hepatitis A virus (HAV). Additionally, the former EOs have a significant inhibitory effect against vesicular stomatitis virus (VSV), and the Cyperus EO inhibited the Coxsackie B4 virus [ 25 , 26 ]. The EO of tea tree (Melaleuca alternifolia) comprising terpinene-4-ol, limonene, γ- and α-terpinene, cineol, and α-terpinolene and the volatile oil (VO) of Cymbopogon citratus have strongly inhibited the oral and genital herpes viruses [ 29 , 30 ], and the oregano EO rich with monoterpenic phenol, carvacrol (5-isopropyl-2-methylphenol), and its isomeric analoge thymol (2-isopropyl-5-methylphenol) derived from Origanum vulgare plant showed a potent protective effect against human and simian immunodeficiency viruses (HIV and SIV) [ 31 ], and the oxygenated and unoxygenated monoterpenes and sesquiterpenes rich herbal Hornstedtia bella EO [ 27 ], and a monocyclic sesquiterpene, germacrene rich Rhizoma curcuma EOs [ 28 ] have inactivated the vaccinia and pseudorabies virus, respectively.…”

Section: Emulsion Components Delivering Antiviral Activitymentioning

confidence: 99%

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Nanoemulsions: The rising star of antiviral therapeutics and nanodelivery system—current status and prospects

Franklyne

Gopinath

Mukherjee

et al. 2021

Current Opinion in Colloid & Interface Science

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Nanoemulsions (NEs) of essential oil (EO) have significant potential to target microorganisms, especially viruses. They act as a vehicle for delivering antiviral drugs and vaccines. Narrowing of drug discovery pipeline and the emergence of new viral diseases, especially, COVID-19 have created a niche to use nanoemulsions (NEs) for augmenting currently available therapeutic options. Published literature demonstrated that EOs have an inherent broad spectrum of activity across bacterial, fungal, and viral pathogens. The emulsification process significantly improved the efficacy of the active ingredients in the EOs. This article highlights the research findings and patent developments in the last two years especially, in EO antiviral activity, antiviral drug delivery, vaccine delivery, viral resistance development, and repurposing EO compounds against SARS-CoV2.

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Chemical Composition, Antiviral and Cytotoxic Activities of Essential Oil fromCyperus rotundusGrowing in Egypt: Evidence from Chemometrics Analysis

Cited by 12 publications

References 22 publications

Cytotoxicity and Antiviral Activities of Haplophyllum tuberculatum Essential Oils, Pure Compounds, and Their Combinations against Coxsackievirus B3 and B4

Cytotoxicity and Antiviral Activities of Haplophyllum tuberculatum Essential Oils, Pure Compounds, and Their Combinations against Coxsackievirus B3 and B4

A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV

Nanoemulsions: The rising star of antiviral therapeutics and nanodelivery system—current status and prospects

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