Chemical Composition, Mosquito Larvicidal and Antimicrobial Activities, and Molecular Docking Study of Essential Oils of Cinnamomum melastomaceum, Neolitsea buisanensis and Uvaria microcarpa from Vietnam

Abstract

The leaf oil compositions of two Lauraceae and one Annonaceae plants cultivated in Vietnam were analysed by GC‐MS (gas chromatography‐mass spectrometry) analysis. The leaf oil of the first Lauraceae plant Cinnamomum melastomaceum contained 34 identified compounds, in which benzyl benzoate (38.5%), linalool (19.9%), (E)‐caryophyllene (10.5%), and α‐terpineol (6.9%) were the major compounds. The leaves of the second Lauraceae plant Neolitsea buisanensis gave an oil with the main compounds (E)‐β‐ocimene (24.0%), benzyl benzoate (15.8%), bicyclogermacrene (14.9%), and (E)‐caryophyllene (6.3%). The leaf oil of the Annonaceae plant Uvaria microcarpa consisted of the principal compounds (E)‐caryophyllene (18.0%), bicyclogermacrene (8.1%), and δ‐elemene (6.1%). Two Lauraceae oil samples exhibited strong mosquito larvicidal activity against Aedes aegypti, Ae. albopictus, and Culex quinquefasciatus with LC50 and LD90 values of less than 50 µg/mL. The Annonaceae oil sample showed strong antimicrobial activity against the fungus Aspergillus niger ATCC 1015 with the MIC (minimum inhibitory concentration) value of 32 µg/mL. In the docking approach, the major compounds (E)‐caryophyllene, bicyclogermacrene, and benzyl benzoate interacted with the mosquito odorant‐binding protein 3OGN, whereas (E)‐caryophyllene, bicyclogermacrene, and δ‐elemene also potentially interacted with the 4ZA5 protein of fungus A. niger

Essential Oil from Vietnamese Peperomia leptostachya Hook. & Arn. (Piperaceae): Chemical Composition, Antioxidant, Anti-Inflammatory, Cytotoxic Activities, and In Silico Analysis

“…The GC-MS analysis was conducted using a Shimadzu Technologies GCMS-QP2010 Plus chromatograph (Shimadzu, Kyoto, Japan), equipped with a fused silica Equity-5 capillary column (30 m × 0.25 mm, film thickness 0.25 µm, Supelco, Bellefonte, PA, USA) [ 38 , 39 , 40 , 41 ]. The analytical parameters were set as follows: helium was utilized as the carrier gas at a flow rate of 1.2 mL/min, while the injector and interface temperatures were maintained at 280 °C.…”

“…The GC-MS analysis was conducted using a Shimadzu Technologies GCMS-QP2010 Plus chromatograph (Shimadzu, Kyoto, Japan), equipped with a fused silica Equity-5 capillary column (30 m × 0.25 mm, film thickness 0.25 µm, Supelco, Bellefonte, PA, USA) [38][39][40][41]. The analytical parameters were set as follows: helium was utilized as the carrier gas at a flow rate of 1.2 mL/min, while the injector and interface temperatures were maintained at 280 • C. The temperature program entailed a ramp from 60 • C (held for 3 min) to 240 • C (held for 15 min) at a rate of 3 • C/min, followed by a final ramp to 280 • C (held for 35 min) at a rate of 5 • C/min for the column.…”

Chemical Constituents, Antioxidant, and Antimicrobial Activities of Ethyl Acetate Fractionated Extract from Rhizomes of Zingiber monophyllum Gagnep.: In vitro and in silico Screenings

“…39 The generic docking technique was used in accordance with the default parameters, and the AutoDock Vina 1.2.3 program carried out the docking operation for the chosen proteins and compounds. [40][41][42] The docked pose with the highest binding affinity and most pronounced amino acid residue interactions for each docked ligand was chosen and visualized by the Discovery Studio Visualizer software.…”