Chemical composition of essential oils of leaves, flowers and fruits of Hortia oreadica

Context: Paederia foetida L. (Rubiaceae) is an edible plant distributed in Asian countries including Malaysia. Fresh leaves have been traditionally used as a remedy for indigestion and diarrhea. Several phytochemical studies of the leaves have been documented, but there are few reports on twigs. Objective: This study investigates the enzyme inhibition of P. foetida twig extracts and compound isolated from them. In addition, in silico molecular docking of scopoletin was investigated. Materials and methods: Plants were obtained from two locations in Malaysia, Johor (PFJ) and Pahang (PFP). Hexane, chloroform and methanol extracts along with isolated compound (scopoletin) were evaluated for their enzyme inhibition activities (10,000–0.000016 µg/mL). The separation and identification of bio-active compounds were carried out using column chromatography and spectroscopic techniques, respectively. In silico molecular docking of scopoletin with receptors (α-amylase and α-glucosidase) was carried out using AutoDock 4.2. Results: The IC 50 values of α-amylase and α-glucosidase inhibition activity of PFJ chloroform extract were 9.60 and 245.6 µg/mL, respectively. PFP chloroform extract exhibited α-amylase and α-glucosidase inhibition activity (IC 50 = 14.83 and 257.2 µg/mL, respectively). The α-amylase and α-glucosidase inhibitory activity of scopoletin from both locations had IC 50 values of 0.052 and 0.057 µM, respectively. Discussion and conclusions: Separation of PFJ chloroform extract afforded scopoletin ( 1 ), stigmasterol ( 2 ) and γ-sitosterol ( 3 ) and the PFP chloroform extract yielded ( 1 ), ( 2 ), ( 3 ) and ergost-5-en-3-ol ( 4 ). Scopoletin was isolated from this species for the first time. In silico calculations gave a binding energy between scopoletin and α-amylase of −6.03 kcal/mol.

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“…Santos et al. (2016) reported that the amounts of pogostol and α-yalangene in Hortia oreadica were dependent on weather conditions. Ozer et al.…”

Section: Resultsmentioning

confidence: 99%

Comparative study of the antidiabetic potential of Paederia foetida twig extracts and compounds from two different locations in Malaysia

Tan

Idris

Kassim

et al. 2019

Pharmaceutical Biology

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“…β-caryophyllene was also identified as a major component in EOs from Galeopsis bifida (22%), Vernonia remotiflora (42.2%), Vernonia brasiliana (36.7%) and Annona foetida (14.19%) (Olennikov et al, 2010;Maia et al, 2010;Costa et al, 2009). In addition, bicyclogermacrene has already been identified as a major constituent in EOs from Hortia oreadica flowers (23.28%), fruits (20.64%) and leaves (from14.71% to 31.37%) (Santos et al, 2016). In vitro antibacterial activity of EOs from S. odoratissima against the microorganisms under study and their potential activities were assessed quantitatively by minimum inhibitory concentration (MIC) values.…”

Section: Resultsmentioning

confidence: 99%

In vitro antimicrobial activity of Spiranthera odoratissima A. St. Hil. essential oils against foodborne pathogens and food spoilage bacteria

et al. 2020

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In Brazilian folk medicine, Spiranthera odoratissima has been used to treat rheumatism, infection and abdominal pain. Essential oils (EOs) are technological options that may be employed in natural foods due to their antimicrobial activities. This paper aimed to investigate the chemical composition and in vitro antibacterial effects of EOs from S. odoratissima leaves and flowers against foodborne and spoilage bacteria Listeria monocytogenes, Salmonella enteritidis, Salmonella typhimurium, Yersinia enterocolitica, Staphylococcus aureus, Escherichia coli, Clostridium botulinum, Bacillus cereus and Pseudomonas aeruginosa. Minimum inhibitory concentration (MIC) values of EOs were calculated by the broth microdilution method on 96-well microplates. Both GC-FID and GC-MS analyses revealed that the major components determined in EOs from S. odoratissima leaves were β-caryophyllene (23.8%), bicyclogermacrene (10.8%) and δ-cadinene (7.1%). Major constituents found in EOs from its flowers were β-caryophyllene (14.1%), spathulenol (8.1%) and γ-cadinene (7.2%). EOs from S. odoratissima leaves and flowers showed strong antibacterial activity against Yersinia enterocolitica (MIC = 0.30 mg/mL), Staphylococcus aureus (MIC = 0.12 mg/mL), Clostridium botulinum (MIC = 0.30 mg/mL), Bacillus cereus (MIC = 0.20 mg/mL) and Listeria monocytogenes (MIC = 0.25 mg/mL). These EOs could be important natural alternatives to prevent bacterial growth in food products.

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“… 37 In 2006, pogostol was confirmed in P cablin and it was proposed that the compound was produced via deprotonation of the germacradienyl cation to germacrene A, followed by deprotonation‐induced cyclization 38 . More recently, pogostol was also identified in essential oils from V zizanoides , Biscogniauxia nummularia , Valeriana jatamansi Jones and Hortia oreadica 31,39‐41 . The structural conformation of pogostol was once again contested as a result of the inconsistencies between the NMR spectroscopic data from the synthetic and naturally occurring compound isolated from B nummularia (Figure 3D).…”

Section: Resultsmentioning

confidence: 99%

“…Valeriana jatamansi Jones and Hortia oreadica. 31,[39][40][41] The structural conformation of pogostol was once again contested as a result of the inconsistencies between the NMR spectroscopic data from the synthetic and naturally occurring compound isolated from B nummularia ( Figure 3D). 39 However, the absolute configuration of pogostol was most recently confirmed using a compound with known stereochemistry, α-bulnesene and its conversion products ( Figure 3E).…”

Section: Aroma Extract Dilution Analysis and Compound Identificationmentioning

confidence: 99%

Key Odorants from Daldinia childiae

Moore

Wickramasinghe

Munafo

2020

Flavour & Fragrance J

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An investigation to identify odorants responsible for a pleasant woody perfumelike aroma produced in the fermentation broth of the fungus Daldinia childiae (JD Rogers & YM Ju) was conducted. Thirty odorants were identified from 30-day-old fermentations employing solvent-assisted flavour evaporation (SAFE) and aroma extract dilution analysis (AEDA). Eleven odorants with flavour dilution (FD) factors ≥16 were quantitated using stable isotope dilution assays (SIDA), and odour activity values (OAV) determined. Odorants with the highest OAVs included guai-11-en-10-ol (woody, OAV 102689), 1-octen-3-one (mushroom, OAV 9025), sotolon (maple, OAV 458), and (2E)-non-2-enal (fatty, OAV 70). An odour simulation model formulated using odorants with OAV ≥ 1 closely matched the sensory attributes of natural D childiae fermentations. Guai-11-en-10-ol, a component of patchouli essential oil used widely in perfumery and cosmetics, was identified as the key impact odorant driving the pleasant woody perfume-like aroma in D childiae fermentations. The findings from this investigation lay the groundwork for future studies on D childiae as a source for the sustainable biotechnological production of guai-11-en-10-ol with potential applications in the flavour and fragrance industry.

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Chemical composition of essential oils of leaves, flowers and fruits of Hortia oreadica

Cited by 18 publications

References 13 publications

Comparative study of the antidiabetic potential of Paederia foetida twig extracts and compounds from two different locations in Malaysia

Comparative study of the antidiabetic potential of Paederia foetida twig extracts and compounds from two different locations in Malaysia

In vitro antimicrobial activity of Spiranthera odoratissima A. St. Hil. essential oils against foodborne pathogens and food spoilage bacteria

Key Odorants from Daldinia childiae

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