Chemical composition of Hypericum species from the Taeniocarpium and Drosanthe sections

Camas, Necdet; Radušienė, Jolita; Ivanauskas, Liudas; Jakštas, Valdas; Kayikçi, Samim; Çırak, Cüneyt

doi:10.1007/s00606-013-0934-3

Cited by 17 publications

(6 citation statements)

References 26 publications

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“…Regarding sect. Taeniocarpium , H. fragile has not yet been studied for its phytochemicals; however, our results on the presence of naphthodianthrones, acylphloroglucinols and some flavonoid compounds are close to those of Camas et al (2014) [ 46 ], who studied, among others, H. confertum , H. linarioides , H. pruinatum and H. thymifolium belonging to sect. Taeniocarpium .…”

Section: Discussionsupporting

confidence: 88%

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Chemical Characterization and Antioxidant Activity of Nine Hypericum Species from Greece

et al. 2023

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Hypericum L. comprises about 500 species distributed almost worldwide. Research has mainly focused on H. perforatum with confirmed biological activity on the alleviation of depression symptoms, among others. The compounds responsible for such activity are considered naphthodianthrones and acylphloroglucinols. Other Hypericum species are less studied or not studied, and further research is needed to complete the characterization of the genus. In this study we evaluated the qualitative and quantitative phytochemical profile of nine Hypericum species native to Greece, namely H. perforatum, H. tetrapterum, H. perfoliatum, H. rumeliacum subsp. apollinis, H. vesiculosum, H. cycladicum, H. fragile, H. olympicum and H. delphicum. Qualitative analysis was performed using the LC/Q-TOF/HRMS technique, while quantitative data were calculated with the single point external standard method. Additionally, we estimated the antioxidant activity of the extracts using DPPH and ABTS assays. Three species endemic to Greece (H. cycladicum, H. fragile, H. delphicum) were studied for the first time. Our results indicated that all studied species are rich in secondary metabolites, mainly of the flavonoids family, with strong antioxidant activity.

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Section: Discussionsupporting

confidence: 88%

“…Apart from the importance of the presence of naphthodianthrones and acylphloroglucinols, the detection of other compounds with significant biological activity has been examined by some researchers [ 16 , 45 , 46 ]. Napoli et al (2018) [ 16 ] examined some species that belong to different sections for their phytochemistry.…”

Section: Discussionmentioning

confidence: 99%

Chemical Characterization and Antioxidant Activity of Nine Hypericum Species from Greece

et al. 2023

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“…Recently, hypericin, pseudohypericin and a proposed precursor of hypercins, and emodin were identified not only Factors for chemical variations in Hypericum species in dark glands, but also in translucent glands as well as in non-secretory tissues throughout the leaves of some in vitro cultured species from Hypericum section (Kucharíková et al, 2016). According to the chemotaxonomic surveys, hypericins are produced only in phylogenetically advanced clades of the genus as Hypericum, Drosocarpium, Thasia, Adenosepalum (Kitanov, 2001), Olympia (Cirak et al, 2016b), Taeniocarpium, and Drosanthe (Camas et al, 2014b), a result of adaptation to some selective factors. Similarly, essential oils are synthesized either in translucent glands or in secretory canals that may be localized in leaves, flowers including petals, sepals, and pistil (Fig.…”

Section: Plant Organ Dependencementioning

confidence: 99%

Factors affecting the variation of bioactive compounds inHypericumspecies

Çırak

Radušienė

2019

Biologia Futura

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The genus Hypericum (Hypericaceae) consists of 484 species from 36 sections with worldwide distribution in different areas. Turkey is considered as hot spot for diversity of Hypericum genus. Despite numerous publications, Hypericum species still attracted considerable scientific interest due to pharmaceutically relevant secondary metabolites: naphthodianthrones, acylphloroglucinol derivatives, phenolic acids, flavonoid glycosides, biflavonoids, and some other valuable constituents. Phytochemical investigations carried out on different Hypericum species provided highly heterogeneous results. The content of bioactive compounds varies significantly due to many internal and external factors, including plant organs, phenological stage, genetic profile, environmental abiotic and biotic factors, such as growing site, light, temperature, radiation, soil drought and salinity, pathogens, and herbivores attack. The variations in content of bioactive compounds in plants are regarded as the main problem in the standardization of Hypericum-derived pharmaceuticals and dietary supplements. The review discusses the main factors contributing to the variations of bioactive compounds and what kind of modulations can increase quality of Hypericum raw material.

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“…Furthermore, some of the previously mentioned compounds can be found in quantities several times higher in various representatives of the genus Hypericum other than H. perforatum. This emphasizes the importance of further studies on the biological potential of these species [2,6]. On the other hand, it is not uncommon that Hyperici herba samples often contain Hypericum species other than the official biological source, which is a direct consequence of herbal material collectors' inability to botanically recognize H. perforatum.…”

Section: Introductionmentioning

confidence: 99%

Biological Activity of Genus Hypericum Sect. Hypericum Species—H. tetrapterum, H. maculatum subsp. immaculatum, H. triquetrifolium

Kladar,

Božin,

Bijelić

et al. 2023

Molecules

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St. John’s wort (Hypericum perforatum, Hypericaceae) has long been used in traditional medicine as a potent remedy, while many other species of this genus have not been thoroughly investigated. The study aimed to detect the biological activity, including antioxidant, antihyperglycemic, anticholinergic, antimicrobial and monoaminoxidase inhibitory potential, of water-alcoholic extracts of three species autochthonous for Serbia and Greece from plant genus Hypericum (section Hypericum—H. tetrapterum, H. maculatum ssp. immaculatum and H. triquetrifolium), followed by phytochemical profiling. The highest amount of phenolics was recorded in H. maculatum subsp. immaculatum extract, while the highest abundance of flavonoids was characteristic of H. tetrapterum extract. Hypericin and hyperforin, quercetin, and its flavonoid, rutin, were present in all of the evaluated species. The evaluated species were good scavengers of DPPH, OH and NO radicals, as well as potent reducers of ferric ions in FRAP assay. Furthermore, the evaluated species were shown as potent inhibitors of monoaminoxidase A and α-glucosidase and modest inhibitors of acetylcholinesterase, monoaminoxidase B and α-amylase. No anti-Candida activity was recorded, but the extracts were effective against MRSA Staphylococcus aureus and Enterococcus sp., as well as against Proteus mirabilis. The obtained results strongly highlight the need for further in vivo studies in order to better define the potential of the medicinal application of the studied species.

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Chemical composition of Hypericum species from the Taeniocarpium and Drosanthe sections

Cited by 17 publications

References 26 publications

Chemical Characterization and Antioxidant Activity of Nine Hypericum Species from Greece

Chemical Characterization and Antioxidant Activity of Nine Hypericum Species from Greece

Factors affecting the variation of bioactive compounds inHypericumspecies

Biological Activity of Genus Hypericum Sect. Hypericum Species—H. tetrapterum, H. maculatum subsp. immaculatum, H. triquetrifolium

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