Chemical Composition of Leaves, Stem, and Roots of Peperomia pellucida (L.) Kunth

Gomes, Paulo Wender Portal; Barretto, Hugo; Reis, José Diogo Evangelista; Muribeca, Abraão de Jesus Barbosa; Veloso, Alice; Albuquerque, Carlos Alberto B.; Teixeira, Andrew Magno; Pinheiro, Wandson Braamcamp de Souza; Pamplona, Sônia; Silva, Consuelo; Silva, Milton

doi:10.3390/molecules27061847

Cited by 14 publications

(8 citation statements)

References 71 publications

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“…The study of Nguyen et al, (2021) showed that the gum was found much iThe results of qualitative analysis of the chemical composition from the extract of P. pellucida were also similar to those reported by Sheikh et al (2013) and Gomes et al (2022), which demonstrated the presence of these substances in P. pellucida. Polyphenols and flavonoids are antioxidants that have beneficial effects on human health, curing and preventing many diseases (Tungmunnithum et al, 2018).…”

Section: Discussionsupporting

confidence: 78%

Antioxidant and in vitro antidiabetic activities of Peperomia pellucida (L.) Kunth extract

Men¹,

Tu²,

Ánh³

et al. 2022

VIS

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Peperomia pellucida (L.) is commonly used as a herbal plant. Its effectiveness in treating inflammatory diseases, digestive disorders, and cancer in tropical and subtropical countries was introduced, especially in field of folk medicine. However, this plant species has not been studied widely in Vietnam, especially for its biological activities. This study was done to determine the antioxidant capacity of P. pellucida by using in vitro and in vivo methods, as well as its inhibitory ability to α-amylase enzyme activity. The total polyphenolic and flavonoid contents of P. pellucida extract were reported to be 359.91±0.77 mg GAE/g and 200.28±1.23 mg QE/g extract, respectively. The results showed the in vitro antioxidant activity of P. pellucida extract in four methods, including DPPH, and ABTS.+, RP and TAC, had EC50 values of 730.34 μg/mL, 84.33 μg/mL, 95.28 μg/mL, respectively, and Abs0.5 value of 114.73 μg/mL. Under H2O2-induced oxidative stress, fruit flies that were raised in the feed medium supplemented with a concentration of 1 mg/mL of P. pellucida extract showed their average survival time, 50% survival time, and 10% survival time at 1.6 times, 1.8 times, and 1.62 times, respectively, higher than those of the control treatment. The ability to inhibit the α-amylase activity in P. pellucida extract was determined with an EC50 value of 115.32±2.65 μg/mL compared with the commercial drug of 18.67±0, 01 μg/mL. The research results showed that P. pellucida is a potential species in the study of natural compounds with antioxidant and antidiabetic activities.

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Section: Discussionsupporting

confidence: 78%

Antioxidant and in vitro antidiabetic activities of Peperomia pellucida (L.) Kunth extract

Men¹,

Tu²,

Ánh³

et al. 2022

VIS

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“…Hence, bioactive extracts and fractions can have their molecular profile revealed in a few weeks or months by metabolite annotation (levels 2 and 3) [21], as established in previous reports by our research group [22][23][24]. In this approach here, we describe the chemical composition and in vitro antibacterial activity against S. aureus for the ethanolic extract and its fractions from the roots of D. nitidula.…”

Section: Introductionmentioning

confidence: 86%

The Roots of Deguelia nitidula as a Natural Antibacterial Source against Staphylococcus aureus Strains

et al. 2022

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Deguelia nitidula (Benth.) A.M.G.Azevedo & R.A.Camargo (Fabaceae) is an herbaceous plant distributed in the Brazilian Amazon, and it is called “raiz do sol” (sun roots). On Marajó Island, quilombola communities use its prepared roots to treat skin diseases commonly caused by fungi, viruses, and bacteria. Thus, in this study, the extract, and its fractions from D. nitidula roots were used to perform in vitro cytotoxic and antibacterial assays against Staphylococcus aureus strains. Thereafter, liquid chromatography–mass spectrometry (LC–MS) was used for the metabolite annotation process. The ethanolic extract of D. nitidula roots show significant bactericidal activity against S. aureus with IC50 82 μg.mL−1 and a selectivity index (SI) of 21.35. Furthermore, the SREFr2 and SREFr3 fractions show a potent bactericidal activity, i.e., MIC of 46.8 μg.mL−1 for both, and MBC of 375 and 93.7 μg.mL−1, respectively. As showcased, SREFr3 shows safe and effective antibacterial activity mainly in respect to the excellent selectivity index (SI = 82.06). On the other hand, SREFr2 shows low selectivity (SI = 6.8), which characterizes it as not safe for therapeutic use. Otherwise, due to a limited amount of reference MS2 spectra in public libraries, up to now, it was not possible to perform a complete metabolite annotation. Despite that, our antibacterial results for SREFr3 and correlated substructures of amino acid derivatives show that the roots of D. nitidula are a natural source of specialized metabolites, which can be isolated in the future, and then used as a support for further bio-guided research, as well as natural drug development.

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“…The temperatures of the column and autosampler were 30 and 8 °C, respectively. The mass spectra of data-dependent acquisition experiments were acquired according to the method previously described, 24 with minor modifications. Data were acquired in centroid format.…”

Section: Metabolomics and Bioinformatics Analysis 261 Untargeted Meta...mentioning

confidence: 99%

Overview of the Metabolite Composition and Antioxidant Capacity of Seven Major and Minor Cereal Crops and Their Milling Fractions

Ribeiro da Silva Lima,

Barros Santos,

P. Gomes

et al. 2024

J. Agric. Food Chem.

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Cereal grains play an important role in human health as a source of macro-and micronutrients, besides phytochemicals. The metabolite diversity was investigated in cereal crops and their milling fractions by untargeted metabolomics ultra-high-performance liquid chromatography−tandem mass spectrometry (UHPLC−MS/MS) of 69 samples: 7 species (barley, oat, pearl millet, rye, sorghum, triticale, and wheat), 23 genotypes, and 4 milling fractions (husk, bran, flour, and wholegrain). Samples were also analyzed by in vitro antioxidant activity. UHPLC−MS/MS signals were processed using XCMS, and metabolite annotation was based on SIRIUS and GNPS libraries. Bran and husk showed the highest antioxidant capacity and phenolic content/ diversity. The major metabolite classes were phenolic acids, flavonoids, fatty acyls, and organic acids. Sorghum, millet, barley, and oats showed distinct metabolite profiles, especially related to the bran fraction. Molecular networking and chemometrics provided a comprehensive insight into the metabolic profiling of cereal crops, unveiling the potential of coproducts and super cereals such as sorghum and millet as sources of polyphenols.

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Chemical Composition of Leaves, Stem, and Roots of Peperomia pellucida (L.) Kunth

Cited by 14 publications

References 71 publications

Antioxidant and in vitro antidiabetic activities of Peperomia pellucida (L.) Kunth extract

Antioxidant and in vitro antidiabetic activities of Peperomia pellucida (L.) Kunth extract

The Roots of Deguelia nitidula as a Natural Antibacterial Source against Staphylococcus aureus Strains

Overview of the Metabolite Composition and Antioxidant Capacity of Seven Major and Minor Cereal Crops and Their Milling Fractions

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