Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat

Takayama, Christiane; de-Faria, Felipe Meira; Almeida, Ana Cristina Alves de; Dunder, Ricardo José; Manzo, Luis Paulo; Socca, Eduardo Augusto Rabelo; Batista, Leônia Maria; Salvador, Marcos José; Souza‐Brito, Alba Regina Monteiro; Luiz-Ferreira, Ânderson

doi:10.1016/j.apjtb.2015.09.027

Cited by 79 publications

(39 citation statements)

References 27 publications

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“…Table 3 shows the chemical constituents of the EO from Rosmarinus officinalis, where the main compounds were eucalyptol (30.75%), α-pinene (20.41%), camphor (18.15%), borneol (5.94%), ethyl iso-allocholate (6.77%), limonene (2.72%), linalool (2.74%), and camphene (2.59%). The main chemical compounds in the EO of R. officinalis grown in Pakistan were 1,8-cineol, camphor, α-pinene, limonene, camphene, and linalool [62], while cineole, camphor, and α-pinene were the main compounds in Brazilian plants [63]. In Tunisian R. officinalis, the EOs were 1.8-cineole and camphor [64].…”

Section: Chemical Composition Of the Eosmentioning

confidence: 95%

The Biofungicide Activity of Some Plant Essential Oils for the Cleaner Production of Model Linen Fibers Similar to Those Used in Ancient Egyptian Mummification

et al. 2020

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In this work, the essential oils (EOs) from Eriocephalus africanus leaf, Vitex agnus-castus leaf and fruit, Cymbopogon citratus leaf, and Rosmarinus officinalis leaf were used as antifungal agents against isolated Aspergillus flavus, Cladosporium cladosporioides, and Penicillium chrysogenum from an ancient Egyptian child’s mummy. The isolated fungi were used to colonize the samples of linen fibers. The best oil was used as a novel natural product for the cleaner production of model linen fibers similar to those used in ancient Egyptian mummification. Standard and original linen fibers were compared with the infected Linen samples using Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analyses. The FTIR revealed the changes in the molecular structure of the cellulose, hemicellulose, and lignin of the infected linen fibers. The cellulose crystallinity indices decreased to 64.61%, 52.69%, and 54.63% in the linen inoculated with A. flavus, C. cladosporioides, and P. chrysogenum compared to the control sample (72.08%), thereby affecting the chemical properties of the cellulose. The mycelia inhibition percentages of the three fungi reached 100% after the leaf EO from V. agnus-castus was applied, followed by C. citratus. The V. agnus-castus leaf EO applied at contraptions of 250, 500, 50, 1000, and 2000 µL/mL showed 100% inhibition for A. flavus and P. chrysogenum and reached 100% against C. cladosporioides at concentrations of 500, 750, 1000, and 2000 µL/mL. C. citratus leaf essential oil applied at concentrations of 500, 750, 1000, and 2000 µL/mL showed 100% inhibition to the growth of A. flavus and C. cladosporioides and reached 100% inhibition against the growth of P. chrysogenum at concentrations of 750, 1000 and 2000 µL/mL. This inhibition could be related to the main compounds of caryophyllene (23.13%), eucalyptol (20.59%), sabinene (β-thujene) (12.2%), γ-elemene (9%), and β-farnesene (6.14%) identified in V. agnus-castus leaf EO or due to the main compounds of β-citral (43.63%) and geranial (41.51%), as identified in the leaf EO of C. citratus by GC/MS. The morphological changes in the hyphae of the fungi were observed via SEM examination, where V. agnus-castus leaf EO, the best active oil, showed potent inhibition to fungi grown on the model linen fiber. In this way, the morphology and the structure of the hyphae were effectively changed. Our findings prove that the designed model linen fiber treated with V. agnus-castus leaf EO is able to preserve wrapping fibres and represents a novel natural alternative for effective fungicidal treatment.

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Section: Chemical Composition Of the Eosmentioning

confidence: 95%

The Biofungicide Activity of Some Plant Essential Oils for the Cleaner Production of Model Linen Fibers Similar to Those Used in Ancient Egyptian Mummification

et al. 2020

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“…Ethanol, one of the exogenous aggressive factors, can lead to ROS involved in the mucosal damage to induce oxidative stress (Takayama and others ). Oxidative stress in the pathogenesis of ethanol‐induced acute gastric mucosal injury induces superoxide anion and lipid peroxide formation, extracellular matrix degradation, and mitochondrial damage (Chakraborty and others ).…”

Section: Evaluation Of Antioxidant Capacity In Cultured Cellsmentioning

confidence: 99%

“…However, there is no consensus about the modulation of antioxidant enzymes in ethanol‐induced ROS damage. In one study, ethanol boosted GPx activity, probably owing to the formation of large quantities of H 2 O 2 (Takayama and others ), whereas another study reported that ethanol decreased GPx activity, and may result in H 2 O 2 accumulation and oxidative stress (Farias‐Silva and others ). Downregulation of SOD and CAT activities in the gastric mucosa of rats exposed to ethanol was due to the accumulation of ROS and MDA concentration (Alvarez‐Suarez and others ), and indomethacin and HCl/ethanol‐induced oxidative gastric mucosal decreased the SOD and CAT activities in rat stomach tissue (Olaleye and Farombi ).…”

Section: Evaluation Of Antioxidant Capacity In Cultured Cellsmentioning

confidence: 99%

“…Several different methods have been used for the induction of gastric lesions. In one study, after being fasted for 24 h, animals were administered with antioxidants (essential oil of Rosmarinus officinalis (R. officinalis) ) for 1 h before induction of gastric injury by absolute ethanol (Takayama and others ). In another study, after being administered with strawberry extracts for 10 d and fasted for 2 h, animals were treated with 1 mL of absolute ethanol to induce gastric lesions (Alvarez‐Suarez and others ).…”

Section: Evaluation Of Antioxidant Capacity In Cultured Cellsmentioning

confidence: 99%

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Evaluation of the Cellular and Animal Models for the Study of Antioxidant Activity: A Review

Zhang

Yin

Huang

et al. 2017

Journal of Food Science

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The mechanisms of antioxidant activities of phytochemicals are highly complex, so various methods to study them have been developed. However, the diverse available methods show inconsistent results. Different stressors, cell models, and animal models have been used to evaluate the antioxidant properties of phytochemicals. However, the literature still lacks a summary of the effects of different stressors, cell models, and animal models on the evaluation of antioxidant activities. Therefore, the mechanisms of action of different oxidative stimuli and the characteristics of the available cell models and animal models are summarized in this review.

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“…Moreover Hur et al (2004) reported the use of Rosemary as an immune stimulant. Recent pharmacological investigations on Rosemary also indicated its diuretic (Haloui et al, 2007), antiproliferative (Hussain et al, 2010), anti-inflammatory (Minaiyan et al, 2011), analgesic (Martínez et al, 2012), psychostimulant (Alnamer et al, 2012), hepatoprotective (Raškovic et al, 2014), antioxidant (Takayama et al, 2016), and antimicrobial (Asressu and Tesema, 2014;Mekonnen et al, 2016) properties.…”

Section: Introductionmentioning

confidence: 99%

Acute skin irritation, acute and sub-acute oral toxicity studies of Rosmarinus officinalis essential oils in mice and rabbit

Mengiste¹,

Dires²,

Lulekal³

et al. 2018

Afr. J. Pharm. Pharmacol.

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In Ankober, Northern Ethiopia, Rosmarinus officinalis has been commonly used for flavoring foods as a condiment; moreover, the plant has also been widely used for different medicinal purposes. The current study was undertaken to provide data on acute and subacute toxicity in mice as well as skin irritation of R. officinalis essential oil in rabbit. Acute dermal and oral toxicity tests were conducted using limited dose of 2000 mg/kg. In sub-acute study, 1000 mg/kg were given by gavage to mice for 28 consecutive days. The mice were weighed and various observations like mortality, behavior, injury, or any signs of illness were conducted once daily during the study period. At the end of each study, biochemical parameters were evaluated and kidney and liver were taken after sacrifice for gross findings and histological analyses. For dermal toxicity, 10% ointment formulation of oils was applied on the rabbit skin to evaluate whether the animals sustained significant skin damage. The LD 50 of R. officinalis essential oil for both dermal and oral administration is greater than 2000 mg/kg. There was no significant difference (p > 0.05) observed in the body weights, biochemical parameters, and gross abnormalities, as compared to the control in subacute study. No mortality was recorded. Pathological studies showed that there were no any macroscopic changes in kidneys and liver and all of them have normal appearance. The data of acute skin irritation test demonstrated that 10% R. officinalis oils ointment formulation did not induce acute toxicity in the skin of the animals. Overall, the findings of this study indicate that R. officinalis essential oil is non-toxic.

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Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat

Cited by 79 publications

References 27 publications

The Biofungicide Activity of Some Plant Essential Oils for the Cleaner Production of Model Linen Fibers Similar to Those Used in Ancient Egyptian Mummification

The Biofungicide Activity of Some Plant Essential Oils for the Cleaner Production of Model Linen Fibers Similar to Those Used in Ancient Egyptian Mummification

Evaluation of the Cellular and Animal Models for the Study of Antioxidant Activity: A Review

Acute skin irritation, acute and sub-acute oral toxicity studies of Rosmarinus officinalis essential oils in mice and rabbit

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