Chemical composition of the plant Punica granatum L. (Pomegranate) and its effect on heart and cancer

Mohammad, Sharrif Moghaddasi; Kashani, Hamed Haddad

doi:10.5897/jmpr11.577

Cited by 29 publications

(7 citation statements)

References 26 publications

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“…The EtOH extracts of P. guajava contained the highest amount of flavonoids, whereas the lowest amounts were showed in S. obtusa EtOH extracts (Table 2). This result is similar to those of previous reports that have found P. granatum and P. guajava EtOH extracts to have high levels of polyphenols and flavonoids [31,55,56]. The most active compound in P. guajava was found to be quercetin along with two flavonoid compounds, namely, quercetin-3-O-glucopyranoside and morin [57].…”

Section: Tpc and Tfc Of The Extractssupporting

confidence: 91%

Anti-Inflammatory and Antioxidant Activities of Medicinal Plants Used by Traditional Healers for Antiulcer Treatment

et al. 2019

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For centuries, many kinds of native plants and their products have been used for the treatment of gastric ulcers by traditional healers in Phayao province. The current study aimed to investigate the polyphenol content in some of these medicinal plants and to point out the relationship between their antioxidant capacity and anti-inflammatory activities. Six species were selected based on ethnopharmacologic considerations: Punica granatum L., Psidium guajava L., Careya arborea Roxb., Gochnatia decora (Kurz) Cabr., Shorea obtusa Wall. ex Blume, and Ficus hispida L.f. The leaves or bark of these plants were extracted with 70% ethanol and water. Anti-inflammatory and antioxidant activities of the extracts were analyzed based on nitric oxide (NO) and proinflammatory cytokine production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and through the determination of scavenging activity. The results demonstrated that the ethanol extract from P. granatum and P. guajava leaves significantly inhibited NO production by suppressing nitric oxide synthase. The extracts also inhibited tumor necrosis factor-α, interleukin-1, and interleukin-6 in terms of both mRNA and protein levels and possessed high antioxidants. These extracts were shown to contain the highest amount of polyphenols. Our study concluded that among the plants studied, P. granatum and P. guajava have the most significant anti-inflammatory and antioxidant activities and polyphenols. These plants may have the potential for use in gastric ulcer therapy due to their indicated properties. Future research should focus on the isolation of their active compounds and their in vivo biological activities. Their beneficial applications need to be warranted by such evidence.

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Section: Tpc and Tfc Of The Extractssupporting

confidence: 91%

Anti-Inflammatory and Antioxidant Activities of Medicinal Plants Used by Traditional Healers for Antiulcer Treatment

et al. 2019

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“…This plant is indigenous to India, South-East Asia, and China, is one of the important anticancer plants belonging to family Asteraceae which is rich in many important secondary metabolites like phenol, flavonoids, and tannin [133,190,226,230,[233][234][235][236][237][238][239]. The essential oils of W. chinensis give a positive effect on lung cancer during the in vitro study [133,226,230,233,190].…”

Section: Wedelia Chinensismentioning

confidence: 99%

“…The GC-MS analysis recorded the presence of two important compounds carvacrol and trans-caryophyllene. High anti-scavenging activities were found at different levels of dose [133,190,226,230,[233][234][235][236][237][238][239].…”

Section: Wedelia Chinensismentioning

confidence: 99%

Triple Negative Breast Cancer (TNBC): Signalling pathways-Role of plant-based inhibitors

Ravindra B. Malabadi,

Sadiya MR,

Kiran P. Kolkar

et al. 2024

Open Access Res. J. Biol. Pharm.

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This review paper highlights and updates the role of plant based inhibitors in controlling the triple-negative breast cancer (TNBC) via blocking the TNBC signalling pathways. Breast cancer is the most common cancer in women. There are several identified types, among which the triple-negative breast cancer (TNBC) is the most fatal for patients. Conventionally, the triple-negative breast cancer (TNBC) is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal receptor 2 (HER2) in breast cancer cells. It is well-known for its metastatic, aggressive characteristics and poor outcome in the clinic. Till today, the treatment of TNBC patients is still a challenging task due to the absence of appropriate targets for drugs. Despite the successes of emerging targeted therapies, relapse, recurrence, and therapy failure rates in TNBC significantly outpace other subtypes of breast cancer. Mounting evidence suggests an accumulation of therapy resistant, Cancer Stem Cell (CSC) populations within TNBCs contributes to poor clinical outcomes. These Cancer Stem Cells (CSC) are enriched in TNBC compared to non-TNBC breast cancers. Approximately 60% of drugs currently used for cancer treatment have been isolated from natural products. Natural plant based products are a well-known treasure house for the development of novel anticancer drugs. Many plant-derived natural compounds have anti-cancer properties, including berberine quercetin, formononetin, calycosin, polyphenols, bioflavonoids, carotene, vitamins, and andminerals. Many plant-derived natural compounds, including vinka alkaloids, vinblastine and vincristine, luteolin, α-mangostin, piperine, silibinin, apigenin, quercetin, fisetin, resveratrol, genistein, 10-gingerol, chalcones, curcumin, epigallocatechin gallate, cyanidin-3-O-glucoside, and glycyrrhizin, have shown anti-cancer properties, especially in the treatment of TNBCs. Therefore, more human clinical trial data is warranted for further evaluation of plant extracts for the treatment of TNBCs.

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“…E S 315,Shaking incubator, Daiki science ltd., Ultraviolet spectrometer, Dragendorff's reagent (R&M Chemicals, Essex, United Kingdom), Chloroform (QReC), 37.0% Hydrochloric Acid (HmbG Chemicals), Ammonia (HmbG Chemicals). Phytochemical Screening [10][11][12][13][14][15][16] Phytochemical screening was carried out with all three extracts separately.…”

Section: Equipmentmentioning

confidence: 99%

Phytochemical Investigation of Punica granatum Seeds

Ying¹,

Tian²,

Yi³

et al. 2017

Madridge J Pharm Res

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Chemical composition of the plant Punica granatum L. (Pomegranate) and its effect on heart and cancer

Cited by 29 publications

References 26 publications

Anti-Inflammatory and Antioxidant Activities of Medicinal Plants Used by Traditional Healers for Antiulcer Treatment

Anti-Inflammatory and Antioxidant Activities of Medicinal Plants Used by Traditional Healers for Antiulcer Treatment

Triple Negative Breast Cancer (TNBC): Signalling pathways-Role of plant-based inhibitors

Phytochemical Investigation of Punica granatum Seeds

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