Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini

Zuo, Qian; Xu, Ding-qiao; Yue, Shi-jun; Fu, Rui-jia; Tang, Yu-ping

doi:10.1007/s11655-024-3708-6

Cited by 3 publications

(1 citation statement)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous studies have demonstrated that these components primarily inhibit cell proliferation, promote cell apoptosis, inhibit tumor angiogenesis, and regulate immune responses, contributing to their effects in liver, lung, colorectal, and breast cancers, among others. 14 , 15 Despite their significant antitumor potential, these compounds exhibit drawbacks such as rapid metabolism, high toxicity, poor water solubility, and short half-life. 16 Moreover, the ideal anticancer drug should selectively target cancer cells without harming normal cells.…”

Section: Introductionmentioning

confidence: 99%

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Zhang,

Zhai,

Sun

et al. 2024

IJN

View full text Add to dashboard Cite

Dried toad skin (TS) and toad venom (TV) are the dried skin of the Bufo bufo gargarizans Cantor and the Bufo melanostictus Schneider , which remove the internal organs and the white secretions of the skin and retroauricular glands. Since 2005, cinobufacini preparations have been approved by the State Food and Drug Administration for use as adjuvant therapies in the treatment of various advanced cancers. Meanwhile, bufalenolides has been identified as the main component of TS/TV, exhibiting antitumor activity, inducing apoptosis of cancer cells and inhibiting cancer cell proliferation or metastasis through a variety of signaling pathways. However, clinical agents frequently face limitations such as inherent toxicity at high concentrations and insufficient tumor targeting. Additionally, the development and utilization of these active ingredients are hindered by poor water solubility, low bioavailability, and rapid clearance from the bloodstream. To address these challenges, the design of a targeted drug delivery system (TDDS) aims to enhance drug bioavailability, improve targeting within the body, increase drug efficacy, and reduce adverse reactions. This article reviews the TDDS for TS/TV, and their active components, including passive, active, and stimuli-responsive TDDS, to provide a reference for advancing their clinical development and use.

show abstract

Section: Introductionmentioning

confidence: 99%

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Zhang,

Zhai,

Sun

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

Efficacy and Safety of Cinobufacini Capsules Combined with Oxaliplatin-Based Chemotherapy for Stage Iii-Iv Colorectal Cancer: A Systematic Review and Meta-Analysis

Wang,

Miao,

Cheng

et al. 2024

Preprint

View full text Add to dashboard Cite

Combinational Antitumor Strategies Based on the Active Ingredients of Toad Skin and Toad Venom

Tian,

Zhao,

Yue

et al. 2024

DDDT

View full text Add to dashboard Cite

A multidrug combination strategy is an important mean to improve the treatment of cancer and is the mainstream scheme of clinical cancer treatment. The active ingredients of traditional Chinese medicine, represented by toad skin and toad venom, have the advantages of high efficiency, low toxicity, wide action and multiple targets and have become ideal targets in combined treatment strategies for tumors in recent years. Toad skin and toad venom are traditional Chinese animal medicines derived from Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider that have shown excellent therapeutic effects on the treatment of various cancers and cancer pain as adjuvant antitumor drugs in clinical practice. The involved mechanisms include inducing apoptosis, arresting the cell cycle, inhibiting cell proliferation, migration and invasion, inhibiting tumor angiogenesis, reversing the multidrug resistance of tumor cells, and regulating multiple signaling pathways and targets. Moreover, a multidrug combination strategy based on a nanodelivery system can realize the precise loading of the active ingredients of toad skin or toad venom and other antitumor drugs and carry drugs to overcome physiological and pathological barriers, complete efficient enrichment in tumor tissues, and achieve targeted delivery to tumor cells and the controlled release of drugs, thus enhancing antitumor efficacy and reducing toxicity and side effects. This article reviewed the clinical efficacy and safety of the combination of toad skin and toad venom with chemotherapeutic drugs, targeted drugs, analgesics and other drugs; evaluated the effects and mechanisms of the combination of toad skin and toad venom with chemotherapy, targeted therapy, radiotherapy or hyperthermia, traditional Chinese medicine, signaling pathway inhibitors and other therapies in cell and animal models; and summarized the codelivery strategies for the active ingredients of toad skin and toad venom with chemotherapeutic drugs, small-molecule targeted drugs, monoclonal antibodies, active ingredients of traditional Chinese medicine, and photodynamic and photothermal therapeutic drugs to provide a basis for the rational drug use of toad skin and toad venom in the clinic and the development of novel drug delivery systems.

show abstract

Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini

Cited by 3 publications

References 91 publications

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Efficacy and Safety of Cinobufacini Capsules Combined with Oxaliplatin-Based Chemotherapy for Stage Iii-Iv Colorectal Cancer: A Systematic Review and Meta-Analysis

Combinational Antitumor Strategies Based on the Active Ingredients of Toad Skin and Toad Venom

Contact Info

Product

Resources

About