Chemical composition, quality control, pharmacokinetics, pharmacological properties and clinical applications of Fufang Danshen Tablet: A systematic review

Zeng, Xuan; Zheng, Yonghua; Liu, Yuling; Su, Weiwei

doi:10.1016/j.jep.2021.114310

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…Apart from these five compounds, Wang et al (2021), have firstly found two novel bioactive compounds of KXP (dehydrotrametenolic and dehydrotumulosic acids) from KXP using HPLC-DAD and HPLC-QTOF-MS/MS. These efforts have also resulted in the widespread use of chromatographic methods for TCM formula quality assessment (Liu et al, 2016b;Fan et al, 2021;Zeng et al, 2021).…”

Section: The Methods For Chemical Ingredient Analysismentioning

confidence: 99%

Multi-omics approaches for in-depth understanding of therapeutic mechanism for Traditional Chinese Medicine

et al. 2022

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Traditional Chinese Medicine (TCM) is extensively utilized in clinical practice due to its therapeutic and preventative treatments for various diseases. With the development of high-throughput sequencing and systems biology, TCM research was transformed from traditional experiment-based approaches to a combination of experiment-based and omics-based approaches. Numerous academics have explored the therapeutic mechanism of TCM formula by omics approaches, shifting TCM research from the “one-target, one-drug” to “multi-targets, multi-components” paradigm, which has greatly boosted the digitalization and internationalization of TCM. In this review, we concentrated on multi-omics approaches in principles and applications to gain a better understanding of TCM formulas against various diseases from several aspects. We first summarized frequently used TCM quality assessment methods, and suggested that incorporating both chemical and biological ingredients analytical methods could lead to a more comprehensive assessment of TCM. Secondly, we emphasized the significance of multi-omics approaches in deciphering the therapeutic mechanism of TCM formulas. Thirdly, we focused on TCM network analysis, which plays a vital role in TCM-diseases interaction, and serves for new drug discovery. Finally, as an essential source for storing multi-omics data, we evaluated and compared several TCM databases in terms of completeness and reliability. In summary, multi-omics approaches have infiltrated many aspects of TCM research. With the accumulation of omics data and data-mining resources, deeper understandings of the therapeutic mechanism of TCM have been acquired or will be gained in the future.

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Section: The Methods For Chemical Ingredient Analysismentioning

confidence: 99%

Multi-omics approaches for in-depth understanding of therapeutic mechanism for Traditional Chinese Medicine

et al. 2022

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“…Thus, by employing the modern biological techniques and pharmacological approaches, studies focusing on clinic syndromes together with the subsequent development of preclinic study system in vitro and in vivo with consistent pathological features, pharmacokinetical behaviour and biomarkers are expected to elucidate the functional mechanisms as well as the rationality and rule for the compatibility art, such as potentiation and assistance in the prescriptions of herb pairs, and also to further reveal the concepts like “remove blood stasis” and “detoxifying” in TCM theories ( Qi et al, 2019 ; Guo et al, 2023 ). Moreover, despite centuries of application, it is critical to perform more extensive clinical studies towards the advancement of mechanism-based on evidence-based medicine on the safety application of DSF, which will provide more comprehensive scientific and authoritative evidence regarding the effectiveness of this herbal formula ( Zeng X. et al, 2021 ).…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Danshen-Shanzha formula for the treatment of atherosclerosis: ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties, and pharmacological effects

Xu,

Yu,

Zhang

et al. 2024

Front. Pharmacol.

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Danshen-Shanzha Formula (DSF) is a well-known herbal combination comprising Radix Salvia Miltiorrhiza (known as Danshen in Chinese) and Fructus Crataegi (known as Shanzha in Chinese), It has been documented to exhibit considerable benefits for promoting blood circulation and removing blood stasis, and was used extensively in the treatment of atherosclerotic cardiac and cerebral vascular diseases over decades. Despite several breakthroughs achieved in the basic research and clinical applications of DSF over the past decades, there is a lack of comprehensive reviews summarizing its features and research, which hinders further exploration and exploitation of this promising formula. This review aims to provide a comprehensive interpretation of DSF in terms of its ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties and pharmacological effects. The related information on Danshen, Shanzha, and DSF was obtained from internationally recognized online scientific databases, including Web of Science, PubMed, Google Scholar, China National Knowledge Infrastructure, Baidu Scholar, ScienceDirect, ACS Publications, Online Library, Wan Fang Database as well as Flora of China. Data were also gathered from documentations, printed works and classics, such as the Chinese Pharmacopoeia, Chinese herbal classics, etc. Three essential avenues for future studies were put forward as follows: a) Develop and unify the standard preparation method of DSF as to achieve optimized pharmacological properties. b) Elucidate the functional mechanisms as well as the rationality and rule for the compatibility art of DSF by focusing on the clinic syndromes together with the subsequent development of preclinic study system in vitro and in vivo with consistent pathological features, pharmacokinetical behaviour and biomarkers. c) Perform more extensive clinical studies towards the advancement of mechanism-based on evidence-based medicine on the safety application of DSF. This review will provide substantial data support and broader perspective for further research on the renowned formula.

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“…Furthermore, some pharmacological studies have been performed to explore the mechanism of FDT. In an in vitro experiment, FDT demonstrated a significant inhibitory effect on platelet aggregation in a dose-dependent manner [9]. In a mouse model of Alzheimer's disease induced by Aβ [25][26][27][28][29][30][31][32][33][34][35] , the oral administration of FDT (0.81 g/kg, 3 weeks) was found to significantly reduce neuroinflammation by inhibiting the TNF-α and IL-6 levels [12].…”

Section: Introductionmentioning

confidence: 99%

“…F.H. Chen), and Bing-Pian (Borneolum syntheticum)-in a weight ratio of 450:141:8 [9]. The herbal information is listed in Table S1.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Mechanism of Fufang Danshen Tablet against Atherosclerosis by Network Pharmacology and Experimental Validation

Liu,

Su,

et al. 2024

Pharmaceuticals

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Atherosclerosis is the main pathological basis of cardiovascular diseases (CVDs). Fufang Danshen Tablet (FDT) is a traditional Chinese medicine that has been clinically used to treat CVDs for more than 40 years. Nevertheless, owing to the complexity of the ingredients, the pharmacological mechanism of FDT in the treatment of CVDs has not been fully elucidated. In this study, an integrated strategy of UFLC-Q-TOF-MS/MS, network pharmacology, molecular biology, and transcriptomics was used to elucidate the mechanisms of action of FDT in the treatment of atherosclerosis. In total, 22 absorbed constituents were identified in rat serum after oral administration of FDT. In silico, network pharmacology studies have shown that FDT regulates four key biological functional modules for the treatment of atherosclerosis: oxidative stress, cell apoptosis, energy metabolism, and immune/inflammation. In animal experiments, FDT exerted protective effects against atherosclerosis by reducing the plaque area and lipid levels in ApoE−/− mice. Furthermore, we found that FDT inhibited inflammatory macrophage accumulation by regulating the expression of Selp and Ccl2, which are both involved in monocyte adhesion and migration. The inhibition of monocyte recruitment by FDT is a new perspective to elucidate the anti-atherosclerotic mechanism of FDT, which has not been adopted in previous studies on FDT. Our results may help to elucidate the therapeutic mechanism of FDT against CVDs and provide potential therapeutic targets.

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Chemical composition, quality control, pharmacokinetics, pharmacological properties and clinical applications of Fufang Danshen Tablet: A systematic review

Cited by 10 publications

References 30 publications

Multi-omics approaches for in-depth understanding of therapeutic mechanism for Traditional Chinese Medicine

Multi-omics approaches for in-depth understanding of therapeutic mechanism for Traditional Chinese Medicine

Danshen-Shanzha formula for the treatment of atherosclerosis: ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties, and pharmacological effects

Exploring the Mechanism of Fufang Danshen Tablet against Atherosclerosis by Network Pharmacology and Experimental Validation

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