Chemical compositions and biological activities of Scutellaria pinnatifida A. Hamilt aerial parts

Abstract

Phytochemical analysis of the methanolic and dichloromethane extracts of the aerial parts of Scutellaria pinnatifida led to the isolation of a phenylpropanoid, 1-o-feruloyl-β-D-glucose (1), two known flavonoids including luteolin-7-o-glucoside (2) and apigenin-7-o-glucoside (3), three known phenylethanoid glycosides composed of phlomisethanoside (4), syringalide A (5), and verbascoside (6), and oleic acid (7). Isolation and structural elucidation of compounds were accomplished by HPLC and spectroscopic methods (UV, 1H-NMR, 13C-NMR). The extracts were also evaluated for their radical scavenging activity and insecticidal property by 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay and contact toxicity method, respectively. Among the extracts, the methanol extract showed the most potent free radical scavenging activity with a RC50 value of 0.044 ± 0.350 mg/mL which could be attributed to the presence of the isolated phenolic compounds. In the case of insecticidal activity, the n-hexane extract displayed the most potent activity and caused 10%, 15%, and 40% mortality to Oryzaephilus mercator at the concentration of 5, 10, and 15 mg/mL after 4 h of exposure.

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach

“…Our results match with reported data of Vergun et al [ 31 ], who studied Scutellaria baicalensis in the same fractions and concentrations against DPPH radical. Our study is also in agreement with the study of Grzegorczyk-Karolak et al [ 32 ], Delazar et al [ 33 ] and Zengin et al, [ 34 ] who have performed the same tests for S. altissima and S. pinnatifida , S. Orientalis L . and S. salviifolia .…”

Skullcapflavone II Inhibits Degradation of Type I Collagen by Suppressing MMP-1 Transcription in Human Skin Fibroblasts

“…Roots of Scutellaria baicalensis , S. litwinowii , and S. pinnatifida are used as herbal medicines due to their anti-tumorigenic, anti-fibrotic, anti-inflammatory, and antioxidant effects [2,3,4,5,6,27,28]. Skullcapflavone II is one of the common components of Scutellaria roots, and it is considered a potential therapeutic compound for use in treating cancer, allergic asthma, and bone diseases.…”

Effect of Methanolic Extract of Scrophularia subuphylla on Ischemia and Reperfusion-Induced Myocardial Injury

“…Consequently, these compositions especially in high value with synergistic effect on cardiac function not only induced no improvement in factors under our investigation, but also developed adverse effects such as arrhythmia. Whereas this plant and other species of this plant contain phenylethanoid and irioid [26][27][28] and cardiac effects of these compounds have already been demonstrated. 7,11,12,28,29 Besides, our previous study showed remarkable cardiovascular effect of S. frigida on isolated rat heart.…”