Chemical compositions and α-glucosidase inhibitory effects of anthocyanidins from blueberry, blackcurrant and blue honeysuckle fruits

Zhang, Jiangtao; Sun, Lijun; Dong, Yan; Fang, Zhongxiang; Nisar, Tanzeela; Zhao, Ting; Wang, Zi-Chao; Guo, Yurong

doi:10.1016/j.foodchem.2019.125102

Cited by 79 publications

(52 citation statements)

References 32 publications

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“…They are converted to anthocyanidins during acid hydrolysis and act as α-glucosidase inhibitors. They are mixed-type inhibitors which establish hydrogen bonds more efficiently to α-glucosidase than α-glucosidase-substrate complex ( Zhang et al, 2019 ).…”

Section: Dietary Sources and Their Bioactive α-Glucosidase Inhibitorsmentioning

confidence: 99%

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

Hossain

Das

Ghosh

et al. 2020

Food and Chemical Toxicology

252

121

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Recently the use of bioactive α-glucosidase inhibitors for the treatment of diabetes have been proven to be the most efficient remedy for controlling postprandial hyperglycemia and its detrimental physiological complications, especially in type 2 diabetes. The carbohydrate hydrolysing enzyme, α-glucosidase, is generally competitively inhibited by the α-glucosidase inhibitors and results in the delayed glucose absorption in small intestine, ultimately controlling the postprandial hyperglycemia. Here we have reviewed the most recent updates in the bioactive α-glucosidase inhibitors category. This review provides an overview of the α-glucosidase inhibitory potentials and efficiency of controlling postprandial hyperglycemia of various bioactive compounds such as flavonoids, phenolic compound, polysaccharide, betulinic acid, tannins, anthocyanins, steroids, polyol, polyphenols, galangin, procyanidins, hydroxyl-α-sanshool, hydroxyl-β-sanshool, erythritol, ganomycin, caffeoylquinic acid, resin glycosides, saponins, avicularin, oleanolic acids, urasolic acid, ethanolic extracts etc., from various dietary and non-dietary naturally occurring sources.

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Section: Dietary Sources and Their Bioactive α-Glucosidase Inhibitorsmentioning

confidence: 99%

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

Hossain

Das

Ghosh

et al. 2020

Food and Chemical Toxicology

252

121

View full text Add to dashboard Cite

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“…Two trans -resveratrol derivatives, rumexoid and piceatannol compounds, also possess some activities [ 5 , 19 ]. Zhang et al [ 20 ] showed that anthocyanidins were more active than anthocyanins in the whole fruits of blueberry, honeysuckle and blackcurrant. The explanation of the anti-α-glucosidase activity by these two families of polyphenols in grape seed was proposed by Yilmazer-Musa et al [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

α-Glucosidase Inhibitory Activity of Tannat Grape Phenolic Extracts in Relation to Their Ripening Stages

et al. 2020

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The present study aimed to screen grape extracts as novel α-glucosidase inhibitors to prevent type-2 diabetes and hyperglycemia. The total polyphenol content (TPC) was measured by Folin-Ciocalteu assay and the stilbene, anthocyanin and flavan-3-ol compounds were measured by Ultra High-Performance Liquid Chromatography coupled to Mass Spectrometry (UHPLC-MS). The α-glucosidase inhibitory of seed and skin Tannat grape extracts at four ripening stages were investigated. The highest TPC values were measured in seeds at the “veraison stage” (65.29 ± 5.33 g of Gallic Acid Equivalent (GAE) per kilogram of Fresh Weight (FW)). This was in accordance with the high flavan-3-ol contents measured for these two extracts (43.22 ± 2.59 and 45.45 ± 6.48 g/kg of seeds FW, respectively). The skin and seed extracts at the first stage of ripening exerted strong α-glucosidase inhibition, exceeding 95% (p < 0.05). A high linear correlation (R = 0.723, p ≤ 0.05) was observed between flavan-3-ol contents and the α-glucosidase inhibitory activity. The stilbene contents and this activity were moderately to strongly anti-correlated (R = –0.828, p ≤ 0.05 for trans-resveratrol). The enzyme kinetic studies revealed a mixed type of inhibition. This study brings promising results for the therapeutic potential of seed and skin Tannat grape extracts as a functional food product with anti-diabetic activity.

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“…Specifically, previous studies have proven the ability of phenolic-rich ingredients (berry extracts, soft-fruits, grape seeds and bitter melon to inhibit the activities of pancreatic α-amylase and intestinal α-glucosidase in the gut lumen [ 51 , 52 ]. Other studies have shown that anthocyanin-rich fractions from blueberry [ 53 ], blackberry [ 54 ], black legumes [ 55 ], black mulberry [ 56 ], bilberry and cranberry [ 57 ], red aril fruits [ 58 ], camelina and ophia seeds [ 59 ], royle fruits [ 60 ], fruits of Chilean berberis species [ 61 ], peach fruit and A. melanocarpa fruit juice extracts [ 62 , 63 ], colored extracts of Saco sweet cherry [ 64 ], and anthocyanin extracts from black bean hull, black currants and black rice [ 65 , 66 ] exhibited higher effectiveness to inhibit α-glucosidase. Therefore, diet-induced treatments from anthocyanin-based extracts, often combined with other polyphenols, may offer a natural alternative to achieve better glycemic control in T2DM.…”

Section: Why Anthocyanins?mentioning

confidence: 99%

“…Recent enzymatic kinetics and in silico studies [ 53 ] determined the α-glucosidase inhibition activities of the main polyphenolic molecules present in blueberry, blackcurrant, and blue honeysuckle fruits. Despite the higher quantity of glycosidic anthocyanins, they observed a better inhibitory activity for anthocyanidins, namely Dpd, Cyd and peonidin (Peo).…”

Section: Why Anthocyanins?mentioning

confidence: 99%

Anthocyanins as Antidiabetic Agents—In Vitro and In Silico Approaches of Preventive and Therapeutic Effects

et al. 2020

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Many efforts have been made in the past two decades into the search for novel natural and less-toxic anti-diabetic agents. Some clinical trials have assigned this ability to anthocyanins, although different factors like the food source, the amount ingested, the matrix effect and the time of consumption (before or after a meal) seem to result in contradictory conclusions. The possible mechanisms involved in these preventive or therapeutic effects will be discussed—giving emphasis to the latest in vitro and in silico approaches. Therapeutic strategies to counteract metabolic alterations related to hyperglycemia and Type 2 Diabetes Mellitus (T2DM) may include: (a) Inhibition of carbohydrate-metabolizing enzymes; (b) reduction of glucose transporters expression or activity; (c) inhibition of glycogenolysis and (d) modulation of gut microbiota by anthocyanin breakdown products. These strategies may be achieved through administration of individual anthocyanins or by functional foods containing complexes of anthocyanin:carbohydrate:protein.

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Chemical compositions and α-glucosidase inhibitory effects of anthocyanidins from blueberry, blackcurrant and blue honeysuckle fruits

Cited by 79 publications

References 32 publications

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

α-Glucosidase Inhibitory Activity of Tannat Grape Phenolic Extracts in Relation to Their Ripening Stages

Anthocyanins as Antidiabetic Agents—In Vitro and In Silico Approaches of Preventive and Therapeutic Effects

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