Chemical Compositions, Antioxidant and Anti-diabetic Activities of Root Wood and Root Bark Essential Oils from <i>Pterocarpus soyauxii</i> TAUB.

Ojah, Emmanuel Onah; Moronkola, Dorcas Olufunke; Ajiboye, Clement Odunayo; Yusuf, Tunde L.; Adeniyi-Akee, Mukaram Akintunde

doi:10.1080/0972060x.2020.1864483

Cited by 4 publications

(4 citation statements)

References 28 publications

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“…Pentacosane, nonacosane, tricosane are known to exhibit antibacterial activity [39]. Presence of norisoprenoids such as dihydroedulan and ionones could also be responsible for the anticancer activity of the plant [42]. Linalool in leaf and anethole in stem oil are both bioactive agents in experimental models and has shown antibacterial, sedative and anti-inflammatory activities [43].…”

Section: Resultsmentioning

confidence: 99%

ISOLATION WITH CHARACTERIZATION OF COLUMBIN AND NOVEL CLERODANE FURANO-DITERPENE WITH GC-MS AND ANTIMICROBIAL ANALYSES OF ESSENTIAL OILS FROM Sphenocentrum jollyanum Pierre

Moronkola¹,

Jaspars²,

Rainer³

et al. 2021

JCSN

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The methanol extract of the seed of Sphenocentrum jollyanum Pierre, was subjected to partition chromatography in gradient elutions, using vacuum liquid chromatography (VLC) and HPLC techniques. It led to the isolation of two compounds labelled as DO5d-2 and DO6, whose structures were determined by complete analyses of their spectroscopic data, utilizing modern techniques (LC-MS, 1H- and 13C-NMR, DEPT-NMR, HSQC, HMBC, COSY and NOESY). The Essential oils of the leaf and stem were extracted by hydro-distillation using Clevenger-typed apparatus and analysed by GC-MS technique. It was subsequently subjected to antimicrobial analysis using the agar diffusion method. The major isolated compound – DO6, was further characterized as ‘columbin’, while DO5d-2 was characterized as a new clerodane type furano-diterpene, which has not been previously reported. Essential oils obtained by hydro distillation from leaf and stem of Sphenocentrum jollyanum Pierre, were dominated by aldehydes in 10.93% and 15.14% respectively. Fifty (50) compounds were identified in leaf oil comprising 68.73% of it, with phytol (6.62%) and n-hexanol (6.28%) as most abundant compounds. Twenty-eight (28) compounds identified in the stem oil comprised 44.90% containing pentadecanal (14.72%) and phytol (6.38%) as its prominent compounds. The antimicrobial result showed the oil from the leaf was active against all the bacterial and fungi tested, while that from the stem revealed moderate activity against the tested bacterial and fungi.

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Section: Resultsmentioning

confidence: 99%

ISOLATION WITH CHARACTERIZATION OF COLUMBIN AND NOVEL CLERODANE FURANO-DITERPENE WITH GC-MS AND ANTIMICROBIAL ANALYSES OF ESSENTIAL OILS FROM Sphenocentrum jollyanum Pierre

Moronkola¹,

Jaspars²,

Rainer³

et al. 2021

JCSN

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“…Carvone Monoterpenoid Improves glycoprotein components and controls glucose metabolism [158] Naphthalene Polycyclic aromatic hydrocarbon α-glucosidase inhibitory activity [133] (E)-Anethole Phenylpropanoid Suppresses diabetic nephropathy in rats by decreasing blood glucose levels and downregulating AT1R and TGF-β1 expressions. [126] Hexahydrofarnesyl acetone Sesquiterpene α-glucosidase inhibition activity [159] (E)-β-Ionone Sesquiterpenoid α-amylase and α-glucosidase inhibitory activities and antioxidant activity [160] Phytol Diterpene Stimulates insulin resistance by activation of nuclear receptors and heterodimerization of RXR with PPARγ [156] Verbena litoralis…”

Section: Carvacrol Monoterpenoidmentioning

confidence: 99%

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Bhattacharya,

Gupta,

Flekalová

et al. 2024

Plants

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Diabetes mellitus (DM) is a global health concern characterized by a deficiency in insulin production. Considering the systemic toxicity and limited efficacy associated with current antidiabetic medications, there is the utmost need for natural, plant-based alternatives. Herbal medicines have experienced exponential growth in popularity globally in recent years for their natural origins and minimal side effects. Ecuador has a rich cultural history in ethnobotany that plays a crucial role in its people’s lives. This study identifies 27 Ecuadorian medicinal plants that are traditionally used for diabetes treatment and are prepared through infusion, decoction, or juice, or are ingested in their raw forms. Among them, 22 plants have demonstrated hypoglycemic or anti-hyperglycemic properties that are rich with bioactive phytochemicals, which was confirmed in several in vitro and in vivo studies. However, Bryophyllum gastonis-bonnieri, Costus villosissimus, Juglans neotropica, Pithecellobium excelsum, and Myroxylon peruiferum, which were extensively used in traditional medicine preparation in Ecuador for many decades to treat diabetes, are lacking in pharmacological elucidation. The Ecuadorian medicinal plants used to treat diabetes have been found to have several bioactive compounds such as flavonoids, phenolics, fatty acids, aldehydes, and terpenoids that are mainly responsible for reducing blood sugar levels and oxidative stress, regulating intestinal function, improving insulin resistance, inhibiting α-amylase and α-glucosidase, lowering gluconeogenic enzymes, stimulating glucose uptake mechanisms, and playing an important role in glucose and lipid metabolism. However, there is a substantial lack of integrated approaches between the existing ethnomedicinal practices and pharmacological research. Therefore, this review aims to discuss and explore the traditional medicinal plants used in Ecuador for treating DM and their bioactive phytochemicals, which are mainly responsible for their antidiabetic properties. We believe that the use of Ecuadorian herbal medicine in a scientifically sound way can substantially benefit the local economy and industries seeking natural products.

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“…The antioxidant activity was measured in terms of hydrogen donating or radical scavenging ability using the stable radical DPPH. The experiment was carried out according to the method of Ojah et al, [8], with a slight modification. Five different concentrations of the sample were prepared and absorbance measurement was taken at 517 nm with the aid of a spectrophotometer.…”

Section: Antioxidant Potentialmentioning

confidence: 99%

GC-MS analyses of four essential oils with antioxidant activity of extracts of Rytigynia umbellulata (Hiern) Robyns

Ezeagwu,

Isamah,

Ajiboye

et al. 2023

JEOPC

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Article InformationEssential oil compositions of leaf, leaf stalk, stem and fruit with phytochemical screening and antioxidant evaluation of extracts obtained from Rytigynia umbellulata (Rubiaceae) were determined in this study. The essential oils were extracted using hydro-distillation method and analysed by gas chromatography coupled with mass spectrometry (GC-MS), while crude extraction was done in methanol, subjected to standard phytochemical tests and antioxidant potential of extracts was done using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The numbers of identified compounds in leaf, leaf stalk, stem and fruit essential oils were 15, 19, 27 and 11, respectively. Saturated hydrocarbons (70.95%) and acyclic diterpene (16.91%) dominate the leaf essential oil, with the most abundant being: cyclohexane (65.22%) and phytol (16.91%). Saturated hydrocarbons were also prominent in essential oils procured from the leaf stalk (67.05%), stem (37.86%) and fruit (40.32%). Carboxylic acids (11.84%) were exclusive to stalk oil, while sesquiterpenes were only identified in the stem oil. Methanol extracts from leaves (66.88 g) and stem (22.68 g) gave extractive yields of 19.11% and 4.73% respectively. Flavonoids, phenolic compounds, tannins, saponins, terpenoids and coumarins were the classes of secondary metabolites revealed in both extracts. Alkaloid was exclusive to the stem extract, while quinone was only in the leaf extract. The antioxidant evaluation showed that the stem extract exhibited better activity (IC50=0.30 mg/mL) compared to the leaf extract (IC50=0.41 mg/mL), while the control, butylated hydroxyanisole had IC50=0.19 mg/mL. The chemical compositions of the essential oils, phytochemical screening and antioxidant activity of the extracts being reported for the first time support the uses of R. umbellulata in ethno-medicine.

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Chemical Compositions, Antioxidant and Anti-diabetic Activities of Root Wood and Root Bark Essential Oils from Pterocarpus soyauxii TAUB.

Cited by 4 publications

References 28 publications

ISOLATION WITH CHARACTERIZATION OF COLUMBIN AND NOVEL CLERODANE FURANO-DITERPENE WITH GC-MS AND ANTIMICROBIAL ANALYSES OF ESSENTIAL OILS FROM Sphenocentrum jollyanum Pierre

ISOLATION WITH CHARACTERIZATION OF COLUMBIN AND NOVEL CLERODANE FURANO-DITERPENE WITH GC-MS AND ANTIMICROBIAL ANALYSES OF ESSENTIAL OILS FROM Sphenocentrum jollyanum Pierre

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

GC-MS analyses of four essential oils with antioxidant activity of extracts of Rytigynia umbellulata (Hiern) Robyns

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