Chemical constituents and ACE inhibitory activity of desert plant Suaeda physophora Pall.

Abstract

Suaeda physophora Pall. is a kind of desert plant mostly growing in saline habitats in Xinjiang Uygur Autonomous Region. In order to have a better utilization of halophytes, a screening for ACE inhibitors from halophytes growing in Xinjiang was carried out. The result showed that the 70% EtOH extract and n-BuOH extract of S. physophora Pall. possessed significant ACE inhibitory activities. So we focused on its biochemical constituents firstly. One new quinazoline alkaloid, namely Suaedine (1), along with six known compounds (2-7) was isolated from the aerial parts of S. physophora Pall. The structure of the new quinazoline alkaloid was established by one-and two-dimensional nuclear magnetic resonance, optical rotation and mass spectrometry analysis. The flavonoid compounds (2-4) and phenolic compound (5) exhibited significant ACE activities. It was the first time to focus on the chemical constituents and bioactivities of this plant.

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

“…The ACE-inhibitory activity of halophyte extracts has been scarcely reported. Men et al [ 35 ] found lower inhibitory activity (83%, 100 mg/mL) in extracts of Suaeda physophora . These authors attributed the ACE-inhibitory activity to the presence of polyphenols in the extracts.…”

Plant betalains: Chemistry and biochemistry

“…Spectral properties of gomphrenin-type betacyanins are listed in The ambiguity in structure elucidation in some cases has been resolved with the use of sophisticated techniques. For example, suaedin was reported as a betacyanin, citryl-celosianin, based on data obtained from paper electrophoresis, paper chromatography, hydrolysis, and silica-gel TLC (Piattelli and Imperato, 1971), but recent report based on HR-ESI-MS, 1 H NMR, 13 C NMR spectra confirmed that the compound was not a betacyanin rather a betacyanin-like (Men et al, 2013). The authors isolated this compound as lilac powder and the structure was elucidated as (10bS,2 0 S)-1,5,6,10b-tetrahydro-8,9[2 0 -(2 00 -hydroxy-00 -carboxylalkenyl)-[1 0 ,3 0 ]-dioxolo]-2H-pyrrolo[2,1-a]isoquinoline-3-one.…”

Review of angiotensin-converting enzyme inhibitory assay: Rapid method in drug discovery of herbal plants

“…[ 60 ] Suaeda physophora Pall has isolated a quinoline alkaloids (Suaeda) and flavonoid compounds that also have a potential of ACE inhibitors activity. [ 65 ] The astilbin (with IC 50 of 4.53 mg/mL) were isolated from Erythroxylum gonocladum plant. [ 56 ] The quercetin isolated from Peperomia pellucida L. Kunth herbs with IC 50 of 7.72 mg/mL.…”