Chemical constituents and acetylcholinesterase inhibitory activity from the stems of Bauhinia pentandra

Abstract

Two steroids (1 and 2), two oxepin derivatives (3 and 4) and seven flavonoids (5)(6)(7)(8)(9)(10)(11) were isolated from the stems of Bauhinia pentandra. Their structures were elucidated on the basis of NMR spectroscopic data, and by comparison with data previously reported in literature. The ethanol extract from the stems of B. pentandra and the compounds, 4, 5, 6, 7, 8 and 11 have been evaluated as acetylcholinesterase inhibitors, and among these, the compound 5 exhibited the strongest activity. In addition, all the isolated compounds are reported for the first time as constituents of B. pentandra.

Simultaneous Quantification of Four Marker Compounds in Bauhinia coccinea Extract and Their Potential Inhibitory Effects on Alzheimer’s Disease Biomarkers

“…candida , and B. ungulata exhibited inhibitory activity against the AChE by retention factor analysis based on the thin layer chromatography technique [ 53 ]. 7,4′-Dihydroxyflavone isolated from the stems of B. pentandra inhibited AChE activity [ 54 ]. In addition, dihydroquercetin in the bark of B. variegata was reported as a good candidate for AD treatment by binding to the active sites of AChE and BChE in molecular docking and molecular dynamics simulations [ 55 ].…”

Flavanols from Nature: A Phytochemistry and Biological Activity Review

“…The study also showed that (+)-catechin, (+)-afzelechin, (−)-epiafzelechin and dulcisflavan inhibit the pro-inflammatory inducible nitric oxide synthase and cyclooxygenase-2 proteins in TNF-α-stimulated HepG2 cells at concentrations as low as 0.1 μM. Catechin-5- O -β- d -glucoside showed anti-inflammatory activity with an inhibition rate of over 33.0% ± 4.0 [ 23 ]. Theaflavins exhibit anti-inflammation effects by down-regulating the activation of NF-κB in macrophages.…”

Bauhinia thonningii Schumach & Thonn (Fabaceae): Phytochemical Screening and Evaluation of the Antibacterial Activity of Barks

“…Ivorian flora is abundant in medicinal plants. Previous phytochemical and biological studies on the plants of the genus Bauhinia revealed the presence of several classes of secondary metabolites including terpenoids, flavonoids and other phenolic compounds with various biological activities [5,6,7,8,9]. Among these plants, Bauhinia thonningii Schumach & Thonn, is employed in traditional medicine to treat various illnesses, including urinary tract infection [10].…”