Chemical constituents and biological activities of different solvent extracts of Prosopis farcta growing in Egypt

Abstract

Different solvent extracts from the aerial part of Prosopis farcta growing in Egypt have been biologically evaluated by studying their antimicrobial, anticancer and antioxidant activities. Furthermore, the chemical analysis using GC/MS has been performed for the promising extracts n-hexane and methylene chloride, and this analysis led to the identification of twenty six and thirty two compounds respectively from n-hexane and methylene chloride. The major compound identified in the n-hexane is (Z) 9,17octadecadienal (10.60%) while for methylene chloride is tricosanoic acid (9.24%). In addition, chromatographic isolation of the ethyl acetate and n-butanol extracts resulted in the isolation of four compounds which were identified as; dihydrokaempferol-3-O-α-L-rhamnoside (1), apigenin (2), 4′methoxyquercetin (tamarixetin) (3) and acacetin-7-O-α-L-rhamnoside (4). n-hexane and methylene chloride showed moderate antimicrobial activities against three microbes for each, that is, Shigella spp., Escherichia coli and Proteus vulgaris for n-hexane and Erwinia spp., Escherichia coli and Staphylococcus epidermis for methylene chloride. On the other hand, the ethyl acetate showed higher antimicrobial activities against Shigella spp., Escherichia coli, and Candida albicans. Likewise nbutanol extract showed higher activity against Shigella spp., Erwinia spp., E. coli, P. vulgaris, S. epidermis and Candida albicans. Moreover, the anticancer activities were evaluated against four human tumor cell lines namely; HepG-2, HeLa, PC3 and MCF-7. The n-butanol extract showed the highest activity against MCF-7 cell line with IC 50 of 5.6 μg/ml compared to 5-fluorouracil with IC 50 of 5.4 μg/ml, while the ethyl acetate showed the highest activity against Hela cell line with IC 50 of 6.9 μg/ml compared to 5-fluorouracil with IC 50 of 4.8 μg/ml. Also, the inhibition percentages (I%) of ABTS radical were 83.1, 82.0, 87.2 and 87.0% respectively for the n-hexane, methylene chloride, ethyl acetate and n-butanol extracts, respectively, compared to ascorbic acid with 89.2%. In, conclusion the different extracts of P. farcta aerial part showed promising antimicrobial, anticancer and antioxidant activities, in which may be return to their identified bioactive secondary metabolites.

Antifungal and anti-termite activities, total phenolic content of Prosopis Farcta extracts; and attempts to develop weed biocontrol method against it

“…Each extract was more active than others against specific bacteria. 28 MeOH and nhexane extracts of aerial parts were prepared and tested against the major pathogenic bacteria of fish, including A. hydrophila, Y. ruckeri and S. iniae. MeOH extract was more active.…”

“…31 Anticancer Among extracts of aerial parts that were prepared with six different solvents, the EtOAc extract had the highest activity. 28 All plant aq. EtOH (80 %, v/v) extract was active against HT-29 cancer cell lines.…”

“…27 n-Butanol extract had the highest antioxidant activity (ABTS), among six extracts that were prepared using different solvents. 28 Ethanolic extract of fruits was tested for antioxidant activity (DPPH, FRAP, ABTS) and found highly active. Total phenolic contents wad determined (62 mg GAE g -1 ) and 27 compounds were identified.…”

Kelulut Honey Ameliorates Oestrus Cycle, Hormonal Profiles, and Oxidative Stress in Letrozole-Induced Polycystic Ovary Syndrome Rats

“…The compound 2,4-Dimethylhept-1-ene is reported to play a role in human metabolites [ 49 ]. In contrast, tetradecane is noted as a phytochemical found in Prosopis farcta plants [ 50 ] and almonds [ 51 ]. Furthermore, a study reported that 2,4-Di-tert-butyl phenol is an antifungal and antioxidant bioactive compound purified from a newly isolated Lactococcus sp.…”

Antidiabetic Potential of Prosopis farcta Roots: In Vitro Pancreatic Beta Cell Protection, Enhancement of Glucose Consumption, and Bioassay‐Guided Fractionation

“…Prosopis farcta (family Fabaceae) is a well-known medicinal plant that grows in Jordan, Kuwait, Turkey, Iraq, Northern Africa, South Western Asia, and Iran (Khuzestan, Gilan, Fars, Hormozgan, Baluchestan, Khorasan, and Tehran provinces). e plant commonly known by its local name as the "Syrian mesquite" generally grows in warm and dryer climate [9].…”