Chemical constituents and chemotaxonomic study of Glycyrrhiza pallidiflora maxim

Dai, Chen; Wang, Shuang; Souza, Cristabelle De; Li, You-Ying; Zhou, Chuang; Qiu, Reng; Xu, Xiaolong; Zhou, Honglei; Wu, Yi

doi:10.1016/j.bse.2020.104204

Cited by 3 publications

(4 citation statements)

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“…The co‐occurrence of the isoliquiritigenin ( 2 ) which is precursor of retrochalcone echinatin seems to reinforce the above hypothesis. Most importantly, the compounds 3 – 5 could be recognized as the specific biomarkers for the genus Glycyrrhiza ; since these type of molecules in retrochalcone skeletons have been only identified in this genus which is also supported by Dai et al [2] . Some of the compounds such as 4‐hydroxybenzoic acid ( 1 ), licochalcone B ( 4 ), tetrahydroxymethoxychalcone ( 5 ) and vestitol ( 6 ) were obtained from G. echinata for the very first time.…”

Section: Resultsmentioning

confidence: 67%

“…[1] Glycyrrhiza is derived from the Greek words of glykos (sweet) and rhiza (root) because of its sweet taste and distributed mainly from East Asia to East Europe. [2] The roots of official species including Glycyrrhiza uralensis Fisch., Glyrrhiza inflata Bat. and G. glabra L. are known as Radix Glycyrrhizae or Liquiritiae radix have been used in various folk remedies for the treatment of several problems, such as liver disorders, fever, neuralgia, asthma, cough, hoarseness of voice, angina, mouth ulcerations, fever and urinary stones since ancient times.…”

Section: Introductionmentioning

confidence: 99%

“…belonging to Fabaceae (Papilionoideae subfamily) is known as licorice and comprises approximately thirty species around the world [1] . Glycyrrhiza is derived from the Greek words of glykos (sweet) and rhiza (root) because of its sweet taste and distributed mainly from East Asia to East Europe [2] . The roots of official species including Glycyrrhiza uralensis Fisch., Glyrrhiza inflata Bat.…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells

Çevik

Erdoğan

Serttas

et al. 2022

Chemistry & Biodiversity

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Cytotoxic activity-guided fractionation studies on Glycyrrhiza echinata roots led to the isolation of eight compounds (1 -8). Chemical structures of the isolates were identified by NMR and MS analysis. Among the tested molecules, retrochalcones namely echinatin (3) (IC 50 = 23.45 -41.83 μM), licochalcone B (4) (IC 50 = 36.04 -39.53 μM) and tetrahydroxylmethoxychalcone (5) (IC 50 = 7.09-80.81 μM) were the most active ones against PC3, MCF7 and HepG2 cells. Moreover, 5 exhibited selectivity on prostate cancer cells (SI: 5.19). Hoechst staining and Annexin V/PI binding assays as well as cell cycle analysis on the compounds 3 (23 μM) and 5 (5 and 7 μM) demonstrated that these retrochalcones induced apoptosis and significantly suppressed cell cycle in G 1 and G 2 /M phases. Furthermore, 3 and 5 showed antimigratory effects on PC3 cells by wound healing assay. The results indicated that tested retrochalcones most particularly 5 could be potential anticancer drug candidates that prevent proliferation and migration of cancer cells.

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Section: Resultsmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells

Çevik

Erdoğan

Serttas

et al. 2022

Chemistry & Biodiversity

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“…The genus of Glycyrrhiza , which belongs to the Fabaceae family, consists of about 20 species from all over the world [ 1 ]. Among these species, Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat.…”

Section: Introductionmentioning

confidence: 99%

Three New Compounds, Licopyranol A–C, Together with Eighteen Known Compounds Isolated from Glycyrrhiza glabra L. and Their Antitumor Activities

et al. 2022

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Glycyrrhiza glabra L., known as licorice, is one of the most famous herbs in the world. In this study, we investigated the phytochemical and antitumor activities of G. glabra, especially its anti-colorectal cancer activities. G. glabra was extracted with 70% methanol, and the ethyl acetate layer was separated by silica gel, ODS, LH-20 column chromatography, and semi-preparative HPLC to obtain the compounds. The structures were determined by NMR and MS methods. Three new compounds named licopyranol A-C (1–3), and eighteen known compounds (4–21) were isolated. Compounds with an isoprenyl group or dimethylpyran ring showed better antitumor activities. Licopyranol A (1) and glycyrol (5) both inhibited the proliferation, reduced clone formation and promoted apoptosis of RKO cells. The Western blotting assays showed that glycyrol significantly reduced the expression of E-cadherin, β-catenin, c-Myc, and GSK-3β proteins in RKO cells, suggesting that glycyrol may inhibit the growth of colorectal cancer RKO cells via the Wnt/β-catenin signaling pathway.

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Discovery, Biomanufacture, and Derivatization of Licorice Triterpenoids

Xiang,

Sun,

Zhang

et al. 2024

J. Agric. Food Chem.

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Triterpenoids are the major active constituents of licorice, a well-known traditional medicinal herb. Licorice triterpenoids, represented by glycyrrhizin and glycyrrhetic acid, have a high structural diversity and are excellent lead compounds for the development of potent pharmaceuticals. However, their further application can be limited by insufficient activities, low bioavailability, and the presence of side effects, as well as the inefficiency of traditional plant extraction processes for compound production. To address these issues, researchers are focusing on rare triterpenoid components in the genus Glycyrrhiza and developing derivatives to preserve or enhance the original physiological activities with improved bioavailability and reduced side effects. At the same time, synthetic biology offers opportunities to shorten the production cycle, create eco-friendly manufacturing processes, and reduce the cost of producing licorice triterpenoids. Although much progress has been achieved in this field in recent years, there is still a lack of a comprehensive review to summarize the overall characteristics of licorice triterpenoids rather than glycyrrhizin and glycyrrhetinic acid. Based on this, our review comprehensively outlines the structures, origins, and pharmacological activities of licorice triterpenoids and predicts their pharmacological activities using the drugCIPHER algorithm. Furthermore, this paper reviews the advances and strategies for the biomanufacturing of licorice triterpenoids using synthetic biology methods and outlines the perspectives and structure−activity relationships for the derivatization of licorice triterpenoids. This review provides new insights into the discovery and synthesis of pharmaceuticals derived from natural triterpenes.

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Chemical constituents and chemotaxonomic study of Glycyrrhiza pallidiflora maxim

Cited by 3 publications

References 50 publications

Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells

Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells

Three New Compounds, Licopyranol A–C, Together with Eighteen Known Compounds Isolated from Glycyrrhiza glabra L. and Their Antitumor Activities

Discovery, Biomanufacture, and Derivatization of Licorice Triterpenoids

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