Chemical constituents and in vitro anticancer cytotoxic activities of Polyalthia plagioneura

Liu, Bingjing; Jian, L. K.; Chen, Guang‐Ying; Song, Xiao‐Ping; Han, Chang‐Ri; Wang, Jing

doi:10.1007/s10600-014-0855-6

Cited by 21 publications

(6 citation statements)

References 5 publications

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“…[22] Synthesis of the 6 a,7-dihydroaporphine scaffold. Finally, we decided to explore whether the just described addition/ cyclisation protocol would be useful for the synthesis of the 6a,7-dihydroaporphine core A, a tetracyclic amine which constitutes the skeleton of dozens of alkaloids such as for example Artabotrine (17), [23] (À )-6a,7-dehydrofloripavidine (18), [24] or Telisatin B (19), [25] among others. [26] We envisaged that if access to sulfonium salts of general formula B could be provided, then, intramolecular hydroamination of the triple bond followed by cyclization of the photochemically generated vinyl radical should deliver the desired tetracycle (Scheme 6).…”

Section: Resultsmentioning

confidence: 99%

Reactivity of 5‐(Alkynyl)dibenzothiophenium Salts: Synthesis of Diynes, Vinyl Sulfones, and Phenanthrenes

et al. 2021

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The reactivity of 5‐(alkynyl)dibenzothiophenium salts 1 is explored in the presence of different nucleophiles, dienes, and under photochemical conditions. Reaction with lithium acetylides affords diynes in moderate yields; while depending on the substitution pattern, the reaction with sulfinates delivers either the alkyne transfer products, alkynyl sulfones, or β‐(sulfonium) vinyl sulfones through addition to the C−C triple bond. Similar behavior is observed when tosylamines are used as nucleophiles. Salts of general formula 1 also react with dienes to render the corresponding Diels‐Alder cycloadducts. The vinyl sulfonium salts obtained by these routes further react with nucleophiles through a Michael addition, dibenzothiophene elimination sequence. Alternatively, they also engage in photoinduced radical cyclizations to produce substituted phenanthrenes. Attempts to use this specific addition/radical cyclization sequence for the construction of the 6a,7‐dehydroaporphine skeleton present in several families of alkaloids are also described.

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Section: Resultsmentioning

confidence: 99%

Reactivity of 5‐(Alkynyl)dibenzothiophenium Salts: Synthesis of Diynes, Vinyl Sulfones, and Phenanthrenes

et al. 2021

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“…IR spectra were recorded with Shimadzu FTIR instrument. 1 was added and stirred from 0 °C to r.t. for 24 h. Water (1 mL) and dioxane (2 mL) was added to this and stirred for 2 h. Solvent was removed under vacuum, CH 2 Cl 2 (25 mL) was added, cooled to 0 °C and filtered. The filtrate was again cooled to 0 °C and filtered.…”

Section: Methodsmentioning

confidence: 99%

Oxidative route to pyrroloisoquinoline-2,3-dione

Kadam¹,

Tilve²

2018

Arkivoc

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We herein report an efficient constructive method for synthesis of structurally important Pyrroloisoquinoline-2,3-dione from dihydroisoquinoline through oxidative cyclisation. Process is optimised to give best efficiency at gram scale and laborious purification techniques such as column chromatography or recrystallisation were avoided in all steps further featuring uniqueness of this method as compared to the available literature.

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“…Its aerial parts and roots exhibited activities for the treatment of cold, cough, sore throat, and dysentery 4 . Several phytochemicals were reported from it such as Stigma-4-en-3-one 5,6 , β-Sitosterol 6, 7 , and Phytol 8,9 . Moreover, biological studies on F. natalensis leaves revealed its anti-microbial effect 10 and alleviating cadmium chloride testicular disruptions 11 .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profile and Antioxidant Capacity of Ficus natalensis Subsp. leprieurii (miq) Cultivated in Egypt: In-vitro Study.

Elish

Baky

Temraz

2023

Azhar International Journal of Pharmaceutical and Medical Scien

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Ficus natalensis Subsp. leprieurii (miq) (F. natalensis) is an evergreen tree belonging to the family Moraceae and is widely distributed in Africa. The leaves of F. natalensis are well-known for their nutritional value and health benefits and were used traditionally to treat several ailments. The objective of this study was to identify the major classes of phytoconstituents, isolate some of them, and investigate the free radical scavenging potential of F. natalensis leaves. The leaves methanol extract of F. natalensis revealed an abundance of flavonoids, tannins, carbohydrates and/or glycosides, sterols, saponins, and triterpenes. Additionally, the total phenolic content (TPC) of F. natalensis methanol extract was 54.8 mg GAE/g and the total flavonoid content (TFC) was 14.78 mg RE/g. Moreover, three triterpenoid saponins were isolated from the methanol extract using different chromatographic techniques and identified by using 1D NMR together with mass spectrometry as 3-methoxy-quinovic acid-28-O-α-L-rhamnopyranoside ester (1), quinovic acid 3-O-methoxy (2), and 3-O-α-L-rhamnopyranoside-quinovic acid (3). Finally, the leaves methanol extract of F. natalensis revealed 2,2-diphenyl-1-picryhydrazyl (DPPH • ) free radical scavenging capacity with IC50=80.22 μg/mL, compared to that of standard rutin (37.5 μg/mL) which suggests that F. natalensis could be a good source for phytochemical leads with higher antioxidant potential and health benefits.

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Chemical constituents and in vitro anticancer cytotoxic activities of Polyalthia plagioneura

Cited by 21 publications

References 5 publications

Reactivity of 5‐(Alkynyl)dibenzothiophenium Salts: Synthesis of Diynes, Vinyl Sulfones, and Phenanthrenes

Reactivity of 5‐(Alkynyl)dibenzothiophenium Salts: Synthesis of Diynes, Vinyl Sulfones, and Phenanthrenes

Oxidative route to pyrroloisoquinoline-2,3-dione

Phytochemical Profile and Antioxidant Capacity of Ficus natalensis Subsp. leprieurii (miq) Cultivated in Egypt: In-vitro Study.

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