Chemical Constituents, Antibacterial and Antifungal Activities of the Aerial Part of Silene Tomentella

Abstract

This study reports the isolation of steroid glycosides and cycloartane glycosides from the aerial parts of Silene tomentella. Two cycloartans group of triterpenoids astrasieversianin II (1) and cycloastragenol (4), including two compounds belonging to steroid glycosides lokundjoside (2) and lineolon (3) are known, were isolated from the aerial part of S. tomentella by chromatographic techniques (CC, TLC, HPTLC). Their structures were established based on extensive spectroscopic analyses and chemical methods, including NMR (1D and 2D) and HR-ESI-MS data. All of these compounds were obtained for the first time for this plant. In addition, the antimicrobial activities of triterpene and steroid glycosides were evaluated against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus subtilis as well as fungi Candida albicans. There was no evidence of antimicrobial action in the isolated triterpene glycosides and steroid glycosides against used microorganisms