Chemical constituents, antioxidant, antiproliferative and apoptotic effects of a new endemic Boraginaceae species: Paracaryum bingoelianum

Erdoğan, Mehmet Kadir; Geçibesler, İbrahim Halil; Behçet, Lütfi

doi:10.1016/j.rechem.2020.100032

Cited by 22 publications

(10 citation statements)

References 83 publications

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“…Plants having strong antioxidant properties also exhibit strong cytotoxicity and anticancer activities (Sammar et al 2019). Several plants and phytocompounds have been reported to exhibit antiproliferative and anticancer activity (Kamaruddin et al 2019;Erdogan et al 2020).…”

Section: Introductionmentioning

confidence: 99%

In vitro study of the antioxidant, antiproliferative, and anthelmintic properties of some medicinal plants of Kokrajhar district, India

2021

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Alstonia scholaris, Cardiospermum halicacabum, Hydrocotyle sibthorpioides, and Hypericum japonicum are important folk medicinal plants used by tribal communities of Bodoland region of Assam to treat helminth infections. Because of their ethnomedicinal values, the present study was designed to investigate the antioxidant, antiproliferative, and anthelmintic activities of the plants. The antioxidant activity was measured by total antioxidant capacity, total phenolics (TPC), total flavonoid (TFC), FRAP, DPPH, ABTS, and TBARS assay. Antiproliferative and apoptosis-inducing activities of plants were conducted in Dalton's lymphoma (DL) cells. Cells were treated for 24 h with different doses (25-200 mg/mL) of plant extracts. Anthelmintic study was conducted by treating the Paramphistomum sp. at different doses of plant extracts. Phytochemical and antioxidant studies showed rich TPC, TFC, and free radical scavenging activity in H. japonicum and H. sibthorpioides. Both the antiproliferative and anthelmintic bioassays showed a dose-dependent efficacy in all plants. H. japonicum showed the strongest anthelmintic activity (LC 50 0.21 mg/mL) followed by H. sibthorpioides (5.36 mg/mL), C. halicacabum (13.40 mg/ mL), and A. scholaris (18.40 mg/mL). Evidently, H. sibthorpioides showed the strongest antiproliferative and apoptosis-inducing activities among all the plants. The study observed a positive correlation between the antioxidant properties and antiproliferative and anthelmintic activities of the plants. We, therefore, conclude that the phytocompounds present in the crude extracts along with antioxidant molecules may have combined effects contributing to the antiproliferative and anthelmintic activities of the plants.

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Section: Introductionmentioning

confidence: 99%

In vitro study of the antioxidant, antiproliferative, and anthelmintic properties of some medicinal plants of Kokrajhar district, India

2021

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“…Several studies have been carried out to explore the antiproliferative and apoptosis-inducing properties of several medicinal plants (Rais et al 2019;Khurshid et al 2020). Phytochemicals and bioactive compounds isolated from plants were also investigated for anti-cancer activity in numerous cell lines (Kamaruddin et al 2019;Erdogan et al 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Several species of citrus have been investigated for its therapeutic potential by many researchers. Accordingly, C. sinensis, C. medica and C. reticulata have been reported to possess anthelmintic property against Haemonchus contortus and P. posthuma (Gainza et al 2015;Aryal et al 2017). Studies have revealed positive relationship between the phenolics and pharmacological properties of the plants (Akkari et al 2016).…”

Section: Discussionmentioning

confidence: 99%

In-vitro study of antiproliferative and anthelminthic property of medicinal plants of Kokrajhar, Assam

Swargiary¹,

Roy²,

Verma³

2021

Preprint

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People living in far-flung areas of the world, especially ethnic tribal people practice traditional medicine as the first choice of disease treatment. The present study investigates the antioxidant, cytotoxicity, and anthelmintic activity of four medicinal plants traditionally used by tribal communities of Bodoland Region of Assam. Total phenolic and flavonoid content was estimated following spectrophotometry method. Antioxidant activity was measured by total antioxidant assay, FRAP, DPPH, ABTS, and TBARS assay. Antiproliferative and apoptosis-inducing activity of plants were carried out in DL cells. Cells were treated for 24 h with different doses of plant extracts. Furthermore, anthelmintic study was carried out by treating the helminth parasite at different doses of plant extracts. Phytochemical and antioxidant study showed rich TPC, TFC, and free radical scavenging activity in H. japonicum and H. sibthorpioides. Both the antiproliferative and anthelmintic activity showed a dose-dependent efficacy in all the plants. H. japonicum showed the strongest anthelmintic activity with LC50 212.78 µg/mL followed by H. sibthorpioides (5.36 mg/mL), C. halicacabum (13.40 mg/mL), and A. scholaris (18.40 mg/mL). On the other hand, H. sibthorpioides showed stronger antiproliferative and apoptosis-inducing activity compared to other plants. The study observed a positive correlation between the antioxidant property and antiproliferative and anthelmintic activities of the plants. We, therefore, conclude that the secondary metabolites along with antioxidant molecules may have combined effects contributing the antiproliferative and anthelmintic activity of the plants.

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“…In this context, herbal-based treatment approaches stand out in the fight against cancer with their low toxic effects and efficacy. The therapeutic potential of medicinal plants has recently aroused a great interest in the treatment and prevention of many diseases, such as cancer [21]. The anticarcinogenic effect of Rheum genus have been shown in several studies.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

The antiproliferative potential of isolated emodin and aloe-emodin from Rheum ribes on different cancer cell lines

Erdoğan

Ağca

Geçibesler

2020

Biological Diversity and Conservation

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Herbal compounds are important resources that used in the treatment of many diseases, and are inspiring in drug design and development. Rheum ribes, a perennial native plant, has potentially diverse medicinal effects, including antioxidant, antibacterial and anti-tumor activity. The key molecules associated with anticancer activity of R. ribes in tumor formation still remains unclear. The present study was aimed to elucidate the antiproliferative effects of two purified compounds, emodin and aloe-emodin, from R. ribes. In our study, chromatographic separation was used to purification of compounds. Experimental 1D and 2D 1H and 13C-NMR spectra helped us to confirm the chemical structures of emodin and aloe-emodin. The viability of human glioblastoma cell line (U373), human breast carcinoma cells (MCF-7), and human colorectal cancer cell line (HT-29) were detected by WST-1 proliferation assay as dose-and time-dependent. The isolated emodin and aloe-emodin from R. ribes, reduced viability of human glioblastoma, breast and colorectal cancer cell lines in dose-and time-dependent manner significantly. These antiproliferative effects may contribute as a possible strategy to the development of new therapeutic approaches in the treatment of cancer.

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Chemical constituents, antioxidant, antiproliferative and apoptotic effects of a new endemic Boraginaceae species: Paracaryum bingoelianum

Cited by 22 publications

References 83 publications

In vitro study of the antioxidant, antiproliferative, and anthelmintic properties of some medicinal plants of Kokrajhar district, India

In vitro study of the antioxidant, antiproliferative, and anthelmintic properties of some medicinal plants of Kokrajhar district, India

In-vitro study of antiproliferative and anthelminthic property of medicinal plants of Kokrajhar, Assam

The antiproliferative potential of isolated emodin and aloe-emodin from Rheum ribes on different cancer cell lines

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