Chemical constituents, experimental and clinical pharmacology of <i>Rosa damascena</i>: a literature review

Akram, Muhammad; Riaz, Muhammad; Munir, Naveed; Akhter, Naheed; Zafar, Sadia; Jabeen, Farhat; Shariati, Mohammad Ali; Akhtar, Naheed; Riaz, Zarfishan; Altaf, Syed Hassan; Daniyal, Muhammad; Zahid, Rabia; Khan, Fahad Said

doi:10.1111/jphp.13185

Cited by 99 publications

(68 citation statements)

References 52 publications

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“…It is a considerable remedy in traditional medicine and a cost-effective herbal therapy with curative utilization in modern medicine (27). In Persian medicine, Rosa damascene is considered a gentle safe laxative and even can be prescribed for children and pregnant women (19,28).…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of a Persian Medicine Formulation on Adult Functional Constipation: A Double-blinded Clinical Trial

et al. 2021

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Background: Constipation is a common disorder, and its management imposes a significant health burden. Integration of complementary and alternative medicine into the current health system may result in beneficial outcomes. Objective: This study aimed to evaluate the efficacy and safety of a Persian medicine preparation ("Jalinous" capsule) on functional constipation. "Jalinous" capsule is a combination of Rose (Rosa damascena), mastic (Pistacia lentiscus), Aloe vera (Aloe barbadensis), and turpeth (Ipomoea turpethum). Methods: From January to December 2019, 126 patients aged 18 - 50 with functional constipation according to Rome IV criteria referred to Imam Khomeini hospital's gastrointestinal disease clinic were blindly randomized into "Jalinous" capsule group and placebo group for four weeks. Both groups received psyllium indeed. The patients were followed up at weeks two and four of the treatment and four weeks after the termination of the intervention. Results: Although the frequency of defecation, percentage of incomplete defecation and evacuation, straining during defecation, using manual maneuver to facilitate evacuation and defecation time showed significant improvement in both groups (P < 0.001), improvements in the intervention group were significantly more than in control group (P < 0.001). At the end of the second and fourth weeks of taking the drug and four weeks after stopping the drugs, the patients in the intervention group reported less frequent hard stool form in comparison to the patients in the control group (P < 0.001). Their overall self-reported improvement in symptoms after the treatment was significantly higher than the patients in the placebo group (P < 0.001). Adverse effects were not serious and mostly were transient. Conclusion: "Jalinous" capsule is an effective and safe treatment for functional constipation in adults, but more studies are needed to make confident conclusions.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of a Persian Medicine Formulation on Adult Functional Constipation: A Double-blinded Clinical Trial

et al. 2021

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“…Although more studies are needed to assess the effectiveness with reasonable certainty, the most studied OEs for anxiety and depression treatment in obstetrics are those of L. angustifolia , C. aurantium var amara , and R. damascena . Among them, the R. damascena EO is too expensive to be included in clinical practice due to the very low yield: one part of OE out of 3,000 parts of flower (Akram et al, 2020). On the contrary, the EOs of C. aurantium var.…”

Section: Discussionmentioning

confidence: 99%

“…The volatile EO components, binding the specific receptors of sensorial nasal neurons that are connected to the olfactory bulbs in the limbic system, stimulate smell, emotion, and memory connected to the hypothalamus. Through this avenue, aromatherapy acts directly on the limbic system, bypassing the oral intake of EOs, thus preserving the woman and fetus from adverse reactions (Akram et al, 2020). Similarly, this path can be pursued in all those conditions that somehow involve individual emotional response, such as delivery pain and the feeling of nausea and vomit.…”

Section: Discussionmentioning

confidence: 99%

Is aromatherapy effective in obstetrics? A systematic review and meta‐analysis

Vito

Cacaci

Martini

et al. 2020

Phytotherapy Research

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The aim of this systematic review is to collect clinical trials conducted using essential oils (EOs) in obstetric symptoms by evaluating if and in which context the aromatherapy practice is effective in obstetrics. The research was conducted by using the databases of EMBASE, Medline, Biosis and Toxcenter, PubMed, and Google Scholar search engine, selecting articles from January 2004 to July 2020. This study was performed according to the MOOSE and PRISMA guidelines. Only the randomized clinical trials were considered, and in cases of multiple publications, it was considered the most up to date information. Biases were highlighted. In the presence of homogeneous data, pooling statistics and meta-analysis were applied. The research led to 71 articles, 17 of which were eligible. Among the trials selected, eight investigated the effectiveness of EOs on anxiety, depression, and stress. Two concerned the treatment of nausea and vomiting, six evaluated the application of EOs on labor for pain treatment, and two showed the effectiveness in the treatment of episiotomy. The heterogeneity of works carried out so far has made it possible to develop a metaanalysis only in the field of pain treatment during childbirth, identifying the effectiveness of the EOs Lavandula spp. and Rosa damascena.

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“…It is suggested that the liposoluble non-polar constituents of this plant are the main responsible for most of the activities mentioned above. The pharmacological effects on the CNS are hypnotics, antidepressants, analgesics and anticonvulsants as well as in the treatment of dementia (Boskabady et al, 2011;Akram et al, 2020). Nayebi et al (2017) found promising evidences for the effectiveness and safety of Damask rose in pain relief but highlighting the need for appropriate clinical trials to verify these indications.…”

Section: Rosaceaementioning

confidence: 99%

A Comparison Study on Traditional Mixtures of Herbal Teas Used in Eastern Mediterranean Area

et al. 2021

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Multipurpose herbal teas with numerous ingredients, in which flowers are the main component, are common in the traditional medicine and pharmacy of Greece and the Eastern Mediterranean countries. In this study, we combine ethnobotany and ethnopharmacology field work techniques and botany and pharmacognosy laboratory methods for the study of traditional herbal mixtures with flowers, we identify their botanical ingredients and record the local medicinal uses of these mixtures, in Greece, Lebanon, Syria, Iran and Turkey. These, and their industrial versions, are analyzed, using morphological and multivariate analysis techniques in order to determine marker species, relevant patterns of combination and local styles. The medicinal properties attributed to the different flowers are discussed in relation with their role in the mixtures. These blends are consumed for their relaxing, digestive, and anti-infective properties. These mixtures are not consumed as a treatment when one is sick but rather to avoid getting sick, as a preventive measure. The formulations can reach forty ingredients (sarantha in Greek, arbain in Arabic language of Palestine), usually entire or coarsely chopped in the more traditional formulations, leading to extreme variability of individual doses. We ask what biological signification this randomness can have. To give an answer requires new and more comprehensive pharmacological approaches. The flowers of Rosaceae, Asteraceae, Lamiaceae, Malvaceae and Fabaceae species characterize these mixtures in which other materials (roots, leaves, and fruits) and other species are present as well. Flowers of some species, particularly of Fabaceae, are exclusively used in mixtures, and their use in monospecific herbal teas is not yet recorded. We draw attention on the urgent need in exhaustively recording in Greece and the Near East, the formulation and use of traditional herbal mixtures and their numerous local variants. To consider these mixtures and the contribution of flowers (most mixtures receive the general name of tea of flowers) merits further extensive study.

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Chemical constituents, experimental and clinical pharmacology of Rosa damascena: a literature review

Cited by 99 publications

References 52 publications

The Efficacy of a Persian Medicine Formulation on Adult Functional Constipation: A Double-blinded Clinical Trial

The Efficacy of a Persian Medicine Formulation on Adult Functional Constipation: A Double-blinded Clinical Trial

Is aromatherapy effective in obstetrics? A systematic review and meta‐analysis

A Comparison Study on Traditional Mixtures of Herbal Teas Used in Eastern Mediterranean Area

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