Chemical Constituents from Acer mandshuricum and Their Effects on the Function of Osteoblastic MC3T3-E1 Cells

Ding, Yan; Liang, Chun; Nguyen, Huu Tung; Kim, Jeong Ah; Kim, Young Ho

doi:10.5012/bkcs.2010.31.04.929

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…PGG, which was previously isolated in our laboratory from winged sumac (Rhus copallinum) [37], showed the most potent antioxidant activity of 4.2 µM. Overall, as expected, the other classes of phenolics, including the flavonoids (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), and other phenolic derivatives (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37) also showed antioxidant activity with a broad range of IC 50 values ranging from 31.8 to 8311.5 µM. However, the sesquiterpenoids, 38 and 39, did not show any antioxidant effects in this assay.…”

supporting

confidence: 64%

New Gallotannin and other Phytochemicals from Sycamore Maple (Acer pseudoplatanus) Leaves

Zhang

Yuan

et al. 2015

Natural Product Communications

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The maple (Acer) genus is a reported source of bioactive (poly)phenols, including gallotannins, but several of its members, such as the sycamore maple (A. pseudoplatanus), remain uninvestigated. Herein, thirty-nine compounds, including a new gallotannin, 1,2,3-triO -galloyl-6-O-(p-hydroxybenzoyl)-β-Dglucopyranoside (1), and thirty-eight (2-39) known compounds, consisting of four gallotannins, one ellagitannin, thirteen flavonoids, eight hydroxycinnamic acids, ten benzoic acid derivatives, and two sesquiterpenoids, were isolated from sycamore maple leaves. Their structures were determined based on NMR and mass spectral analyses. The isolates were evaluated for α-glucosidase inhibitory and antioxidant activities. Among the isolates, the gallotannins were the most potent α-glucosidase inhibitors with thirteen-fold more potent activity compared with the clinical drug, acarbose (IC 50 = 16-31 vs. 218 μM). Similarly, the gallotannins showed the highest antioxidant activities, followed by the other phenolic sub-classes, while the sesquiterpenoids were inactive.

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supporting

confidence: 64%

New Gallotannin and other Phytochemicals from Sycamore Maple (Acer pseudoplatanus) Leaves

Zhang

Yuan

et al. 2015

Natural Product Communications

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“…The 13 C-NMR spectrum (DMSO- d 6 ) showed fifteen carbon signals, among which six are assigned to one sugar unit, nine to the aglycone moiety, and the nine aglycone moiety carbon signals were attributed to two methyl signals, two methine signals and five quaternary carbons by DEPT and HMQC spectra. By analyzing the 1 H-and 13 C-NMR data along with the reported data [ 11 ], the aglycone moiety was identified as the derivative of gallic acid. The correlations of one methyl protons at δ 3.77 to C-3 at δ 153.0 and another methyl protons at δ 3.79 to C-7 at δ 166.2 in the HMBC spectrum indicated that one methyl group is connected to C-3 through oxygen and another methyl group to C-7 through oxygen.…”

Section: Resultsmentioning

confidence: 99%

Isolation and Identification of the Phenolic Compounds from the Roots of Sanguisorba officinalis L. and Their Antioxidant Activities

et al. 2012

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Four phenolic compounds were isolated from the roots of Sanguisorba officinalis L. by silica gel column chromatography and preparative HPLC. On the basis of chemical and spectroscopic methods, their structures were identified as methyl 4-O-β-D-glucopyranosy-5-hydroxy-3-methoxylbenzoate (1), 3,3′,4′-tri-O-methylellagic acid (2), fisetinidol-(4α-8)-catechin (3), and (+)-catechin (4). Compound 1 is a new phenolic glycoside and compounds 2 and 3 were isolated from the Sanguisorba genus for the first time. Compounds 1–4 were also assayed for their antioxidant activities using the DPPH free radical assay.

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“…The structure elucidation of the compounds was performed based on 2D NMR and HR-MS analyses. They were identified as gallic acid (2) (3) (Choi et al, 2013), 4-methoxyl-5-hydroxymethyl 3-O-β-Dglucopyranoside benzoic acid (5) (Ding et al, 2010), 3,5dihydroxy-4-methoxy benzoic acid methyl ester (6) (Arisawa et al, 1991), and eriodictyol 7-O-methylether 3′-O-β-Dglucopyranoside (7) (Wada et al, 1986) (Fig. 1).…”

Section: Isolation Of the Active Compounds From The Methanolic Extracmentioning

confidence: 99%

Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruits

Zeraik

Queiroz

Marcourt

et al. 2016

Journal of Functional Foods

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A B S T R A C TThe methanolic extract of umbu (Spondias tuberosa) presented high antioxidant activities in the DPPH, ABTS and ORAC assays, as well as acetylcholinesterase (AChE) inhibition activity. The dichloromethane extract exhibited cancer chemopreventive activity, with a quinone reductase induction in Hepa1c1c7 cells. The localization of the active compounds was performed by HPLC activity-based profiling, and preliminary structural information was obtained by HPLC-PAD-ESI-MS and UHPLC-TOF-HRMS. The main constituents from the methanolic extract were efficiently isolated in a single step by preparative MPLC-UV. Two new natural products were identified, together with five known compounds. The structures of the compounds were elucidated by 2D NMR and ESI-HRMS. The dichloromethane extract was fractionated by SPE and by semi-preparative HPLC-UV-ELSD. Using this approach, one anacardic acid derivative was isolated. However, this compound was not responsible for QR induction. This study highlights the potential of umbu as an active ingredient for functional food formulations.

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Chemical Constituents from Acer mandshuricum and Their Effects on the Function of Osteoblastic MC3T3-E1 Cells

Cited by 6 publications

References 8 publications

New Gallotannin and other Phytochemicals from Sycamore Maple (Acer pseudoplatanus) Leaves

New Gallotannin and other Phytochemicals from Sycamore Maple (Acer pseudoplatanus) Leaves

Isolation and Identification of the Phenolic Compounds from the Roots of Sanguisorba officinalis L. and Their Antioxidant Activities

Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruits

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