Chemical Constituents from Albiziae Cortex and Their Ability to Ameliorate Steatosis and Promote Proliferation and Anti-Oxidation In Vitro

Abstract

This study describes the chemical constituents of Albiziae Cortex and their ability to ameliorate steatosis and promote proliferation and anti-oxidation in vitro. Together, five known lignan glycosides, (7S,8R)-erythro-syringylglycerol-β–O-4′-sinapyl ether 9-O-β-D-glucopyranoside (1), (+)-lyoniresinol-9′-O-gluco-side (2), (−)-lyoniresinol-9′-O-glucoside (3), picraquassioside C (4), and icariside E5 (5), were isolated from the Albiziae Cortex. Their structures were elucidated by extensive NMR and high-resolution mass spectrometry analysis and compared with reported data. Oil Red O staining results revealed that compounds 1, 2, and 3 attenuated lipid accumulation and lipid metabolic disorders in FFAs (oleate/palmitate, 2:1 ratio, 0.3 mM)-exposed HepG2 cells. The Cell Counting Kit 8 (CCK-8) assay results revealed that compounds 1 and 5 can significantly promote human umbilical vein endothelial cell (HUVEC) proliferation; meanwhile, these compounds did not exhibit significant cytotoxicity against HUVECs. In addition, 2‘,7‘-dichlorofluorescein diacetate (DCFH-DA) staining results revealed that high glucose (HG)-induced reactive oxygen species (ROS) production was abolished by compounds 1, 2, and 3. This is the first report of the isolation of lignan skeletons from the genus Albizzia julibrissin with the ability to ameliorate steatosis and promote proliferation and anti-oxidation activities.

Chemical profile of Stachytarpheta schottiana by LC-HRMS/MS dereplication and molecular networking

“…The phenylethanoids verbascoside and isoverbascoside have described anti-hepatotoxic, anti-inflammatory, anti-nociceptive and antioxidant activities (Jiménez & Riguera 1994;Jin et al 2004). Also, the suggested lignans have biological activitied already described, such as the ability to alleviate hepatic steatosis and reduce High Glucose (HG)-induced Reactive Oxygen Species (ROS) in vitro of both isomers (+)/(−)-lyoniresinol 9'-O-glucoside (Shi et al 2019), the neuroprotective activity of acanthoside B (Karthivashan et al 2019) and in vitro anti-inflammatory and antioxidant potential of dehydrodiconiferyl alcohol 4-β-Dglucoside (Shan et al 2018;Yang et al 2019) . The activities described for the compounds pointed by this work matches the effects related to the folk use of S. schottiana as a hepatoprotective plant, as cited by Boscolo & Senna Valle (2008), suggesting this species as a potential candidate for studies focused in hepatic diseases.…”

Two Lignan Glycosides from Albizia julibrissin Durazz. Noncompetitively Inhibit Serotonin Transporter

“…include triterpenoids, lignans, flavonoids, saponins, and sterols [ 1 ]. Preclinical studies showed that these ingredients exhibit a broad array of pharmacological activities ranging from antidepressant and anxiolytic [ 2 , 3 , 4 , 5 ], anti-inflammatory [ 6 , 7 ], antioxidant [ 8 ], and antitumor [ 9 , 10 ], to the enhancement of immunological function [ 11 ]. Their molecular mechanisms of action, however, are not understood.…”

Study on Chemical Components from Derris taiwaniana and Their Lung Epithelial Cell Protect Effects

“…By comparing the data with the published articles, and considering their physical and spectroscopic data, it was determined that the known compounds are formononetin ( 3 ), [7] daidzein ( 4 ), [8] 4′,7‐dihydroxy‐3′‐methoxyisoflavone ( 5 ), [9] calycosin ( 6 ), [10] genistein ( 7 ), [11] biochanin A ( 8 ), [12] 3′‐hydroxygenistein ( 9 ), [13] pratensein ( 10 ), [14] 5,7,4′‐trihydroxy‐3′‐methoxyisoflavone ( 11 ), [15] rothindin ( 12 ), [16] ononin ( 13 ), [17] genistin ( 14 ), [18] formononetin‐7‐ O ‐ β ‐D‐apiofuranosyl‐(1→6)‐ β ‐D‐glucopyranoside ( 15 ), [19] 4′‐hydroxy‐3′‐methoxyisoflavone‐7‐ O ‐ β ‐D‐apiofuranosyl‐(1→6)‐ β ‐D‐glucopyranoside ( 16 ), [5] ambocin ( 17 ), [20] auriculasin ( 18 ), [21] 13‐homo‐13‐oxa‐6a,12a‐dehydrodeguelin ( 19 ), [22] (6a R ,12a R )‐tephrosin ( 20 ), [23,24] (−)‐maackiain ( 21 ), [25,27] (−)‐medicarpin ( 22 ), [25,27,28] 3′‐methoxycoumestrol ( 23 ), [29] (+)‐catechin ( 24 ), [25,30,31] (−)‐epicatechin ( 25 ), [25,30,32] isophyllocoumarin ( 26 ), [25,30,33] isoepiphyllocoumarin ( 27 ), [25,30,33] phyllocoumarin( 28 ), [25,30,33] epiphyllocoumarin ( 29 ), [25,30,33] 2 α ,3 α ‐epoxy‐5,7,3′,4′‐tetrahydroxyflavan‐(4 β ‐8‐catechin) ( 30 ), [30,34] (−)‐lyoniresinol‐9′‐ O ‐ β ‐D‐glucopyranoside ( 31 ), [35,36] and (−)‐lariciresinol‐4‐ O ‐ β ‐D‐glucopyranoside ( 32 ) [37]…”