Chemical constituents from Bidens bipinnata Linn.

Hu, Hai-Min; Bai, Shu-Min; Chen, Lijiao; Hu, Wenyi; Chen, Guang

doi:10.1016/j.bse.2018.05.005

Cited by 13 publications

(4 citation statements)

References 51 publications

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“…The isolation work also produced a low yield of the triterpene ketone friedelin (Figure S1). This is a common plant natural product, including from other Asteraceae …”

Section: Resultsmentioning

confidence: 99%

Halimane Diterpenes in the Alpine DaisyCelmisia viscosa: Absolute Configuration, 2,6-Dideoxyhexopyran-3-ulosides, Conformational Flexibility, and Intraspecific Variation

et al. 2022

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The methyl-migrated bicyclic skeleton of the halimane diterpenes has been found in a wide range of organisms, including flowering plants, liverworts, marine animals, and bacteria. The discovery of halima-1(10),14-dien-13-ol (3) from the Aotearoa New Zealand endemic alpine daisy Celmisia viscosa is now reported. The full configuration was assigned for the first time by X-ray crystallography, enantiomeric to that of a liverwort isolate. The absolute configuration at C-5 of the halimane is opposite to that at C-5 of the labdane epimanool (1) found in some C. viscosa specimens. Two new 2,6-dideoxyhexopyran-3-uloside halimane derivatives (4 and 5) were also found, and the absolute configuration of 5 was determined by 1H NMR analysis of the Mosher esters. Line broadening in the 13C NMR spectra of these halim-1(10)-enes was due to conformational exchange in the decalin ring A, as shown by molecular modeling and DFT calculations. 1H NMR and GC analyses of leaf extracts of individual plants from across the full geographic range of C. viscosa revealed intraspecific variation of diterpenes: 37 samples had halimadienol as the main diterpene in large amounts and 2 specimens had predominantly epimanool, again in large amounts. Three other viscid (sticky leaved) Celmisia species also contained diterpenes, but none was detectable in four nonviscid Celmisia species.

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“…The isolation work also produced a low yield of the triterpene ketone friedelin (Figure S1). This is a common plant natural product, including from other Asteraceae …”

Section: Resultsmentioning

confidence: 99%

Halimane Diterpenes in the Alpine DaisyCelmisia viscosa: Absolute Configuration, 2,6-Dideoxyhexopyran-3-ulosides, Conformational Flexibility, and Intraspecific Variation

et al. 2022

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“…catechin, hyperin, isoquercitrin, astragalin and quercetin. Later on, Hu et al (2018) conducted a phytochemical study and indicate the presence of nine ceramides, thirteen flavonoids, one triterpenoid and one polyacetylene. However bioactivities of these isolated compounds has not been investigated.…”

Section: Discussionmentioning

confidence: 99%

In-vitro examination and isolation of antidiarrheal compounds using five bacterial strains from invasive species Bidens bipinnata L.

Zahara

Bibi

Arshad

et al. 2022

Saudi Journal of Biological Sciences

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Bidens bipinnata is widely utilized medicinal plant for treatment of diseases like malaria, sore throat, acute nephritis and dysentery. However, despite its traditional uses Bidens bipinnata is not widely explored for its antimicrobial effect. Thus, the current study is aimed to form antimicrobial activity report of Bidens bipinnata extracts, along with isolation and evaluation of antibacterial activity of the isolated compounds through bioassay-guided purification. Hexane extract of its leaves has appeared to be most active thus it is exposed to automated column chromatography. Further purification using High-performance liquid chromatography has led to isolation of active peaks, identified by Gas Chromatography-mass spectrometry, as 16-Pregnenolone and 9-Octadecenoic acid (Z)-, methyl ester. Their antimicrobial activity was confirmed via broth dilution procedure on Staphylococcus aureus , 16-Pregnenolone revealed a strong antimicrobial activity with MIC 50 of 72 μg/mL whereas 9-Octadecenoic acid (Z)-, methyl ester display an MIC 50 of >250 μg/mL. Present study is the first report on isolation of these compounds from Bidens bipinnata.

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“…Bidens bipinnata L., belonging to the family of Asteraceae, is an annual plant and widely distributed in tropical, subtropical and temperate regions (Hu, Bai, Chen, Hu, & Chen, 2018). In China, the whole plant has been used as folk medicine for treatment of sore throat, chronic diarrhea, malaria, dysentery, hepatitis and acute nephritis (Wang et al, 2014; Yang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Owing to these beneficial effects, the plant is cultivated in southern China and consumed as functional tea. Phytochemical studies have revealed that B. bipinnata L. contains functional ingredients including flavonoids, essential oils, phenols, organic acids, polyacetylenes and steroids (Hu et al, 2018; Li, Kuang, Okada, & Okuyama, 2005; Li, Kuang, Yoshihito, & Okuyama, 2003; Li, Kuang, Yoshihito, & Okuyama, 2004a; Li, Kuang, Yoshihito, & Okuyama, 2004b; Yang et al, 2012). Pharmacological studies have demonstrated that the extracts of B. bipinnata L. possess a wide spectrum of bioactivities, such as antioxidant, anti‐inflammatory, antibacterial, antihypertensive, hepato‐protective and antidiabetic (Wang et al, 2014; Yang et al, 2012; Yuan et al, 2008; Zhong, Chen, Yuan, Wang, et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Enrichment of flavonoid‐rich extract from Bidens bipinnata L. by macroporous resin using response surface methodology, UHPLC–Q‐TOF MS/MS‐assisted characterization and comprehensive evaluation of its bioactivities by analytical hierarchy process

Yang

Bai

Zhang³

et al. 2020

Biomedical Chromatography

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The extract of Bidens bipinnata L. exhibited wide spectrum of bioactivities owing to the presence of flavonoids. In this study, a purification process was developed to enrich the flavonoid-rich extract from B. bipinnata L. (BBTF). AB-8 resin was selected for the purification of total flavonoids. Response surface methodology coupled with Box-Behnken design was employed to optimize the purification condition; it was optimized as pH 5.1, volume of ethanol 80 ml, flow rate of ethanol 1.8 bed volume per hour (BV/h) and concentration of ethanol 76.0%. The total flavonoid content of BBTF was 56.48% under the optimal conditions. The identification of flavonoids in BBTF was conducted using UHPLC-ESI-Q-TOF MS. A total of 14 compounds, including 12 flavonoids, were identified in BBTF. Finally, the in vitro antioxidant activities, α-glucosidase and α-amylase inhibitory activities of BBTF were comprehensively analyzed by an analytical hierarchy process. The results indicated that it exhibited higher bioactivities than the crude extract. These findings suggested that the optimized process could significantly enhance the purity of flavonoids and their bioactivities. This study showed a comprehensive analysis of a total flavonoid extract of B. bipinnata L. for the first time, which could provide a useful approach for its purification process and quality control as well as bioactivities.

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Chemical constituents from Bidens bipinnata Linn.

Cited by 13 publications

References 51 publications

Halimane Diterpenes in the Alpine DaisyCelmisia viscosa: Absolute Configuration, 2,6-Dideoxyhexopyran-3-ulosides, Conformational Flexibility, and Intraspecific Variation

Halimane Diterpenes in the Alpine DaisyCelmisia viscosa: Absolute Configuration, 2,6-Dideoxyhexopyran-3-ulosides, Conformational Flexibility, and Intraspecific Variation

In-vitro examination and isolation of antidiarrheal compounds using five bacterial strains from invasive species Bidens bipinnata L.

Enrichment of flavonoid‐rich extract from Bidens bipinnata L. by macroporous resin using response surface methodology, UHPLC–Q‐TOF MS/MS‐assisted characterization and comprehensive evaluation of its bioactivities by analytical hierarchy process

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