Chemical Constituents from Chloranthus elatior and Their Inhibitory Effect on Human Dihydroorotate Dehydrogenase

Yang, Qian; Jia, An; Liu, Xizi; Han, Shiyi; Fan, Shuochao

doi:10.1055/a-1449-2642

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…In addition, compounds 1-15 were also tested for their antihuman dihydroorotate dehydrogenase activity by the reported method [28]. Nonetheless, they did not show any benefit (Data not shown).…”

Section: Resultsmentioning

confidence: 99%

Triterpenoids from Alisma orientale and their NF-кB Inhibitory Activity

Yang

Li²,

Liu

et al. 2021

Planta Medica International Open

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The rhizome of Alisma orientale (sam.) Juz. is used in clinics for eliminating dampness, reducing edema, and promoting diuresis. This study aimed to elucidate the compounds and investigate their nuclear factor-kappa inhibitory activities in human embryonic kidney 293 cells. A new triterpene, alismaketone B (1); a new natural nortriterpene, noralisolic acid A (2); and 13 known protostane-type triterpenes were isolated from the rhizome of A. orientale. The new structures and their absolute configurations were established using HRESIMS, NMR, and electronic circular dichroism experiments. All isolated compounds were evaluated for their inhibitory activity on NF-κB. The compounds 8, 9, 10, and 14 showed moderate NF-κB inhibitory activities with their IC50 values being 64.7, 32.3, 47.3, and 37.3 μM, respectively.

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Section: Resultsmentioning

confidence: 99%