Chemical constituents from Kielmeyera rugosa Choisy (Clusiaceae)

Nogueira, Paulo C.L.; Andrade, Moacir dos Santos; Andrade, Larissa M.; Moraes, Valéria R. S.; Ribeiro, A. S.; Bittrich, Volker; Amaral, Maria do Carmo Estanislau do; Ferreira, Antônio G.; Alcantara, Glaucia Braz; Leão, Katyúscya Veloso; Alves, Péricles Barreto

doi:10.1016/j.bse.2008.10.003

Cited by 7 publications

(16 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite 4-alkyl and 4-phenyl coumarins having been identified as the major constituents of some species that occur mainly in the cerrado (Gottlieb et al, 1969;Gottlieb & Stefani, 1970) and restinga (Cruz et al, 2002;Nogueira et al, 2008) and xanthones from species collected in the atlantic forest (Garcia-Cortez et al,1998;Pinheiro et al, 2003a), K. variabilis did not demonstrate the same pattern as observed by previous studies. The presence of flavonoids in this species is in agreement with previous reports from other genera in the Calophylleae tribe as Caraipa (Silveira et al, 2010), Mesua (Banerji & Chowdhury, 1993) and Calophyllum (Cechinel et al, 2009).…”

Section: Resultsmentioning

confidence: 57%

“…Triterpenes with different carbon skeletons that include lupeol, friedelin, β-amyrin and the sterol β-sitosterol, were found in K. rugosa Choisy (Nogueira et al, 2008), K. lathrophyton Saddi (Cruz et al, 2001), K. candidissima (Ferreira et al, 1972), K. speciosa A. St.-Hil. and K. rugosa Choisy (Nogueira et al, 2008), respectively. Indeed, GarciaCortez et al (1998) obtained a mixture of 27-O-cis and trans-p-coumaroylcylicodiscic acid, lupeol derivated triterpenes from a dichloromethane extract of K. coriaceae leaves.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis

Cota¹,

Siqueira²,

Oliveira³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Abstract:Many phenolic compounds such as xanthones, quinones and coumarins have been isolated from Kielmeyera species; however the presence of flavonoids have been showed in other genera in the Calophylleae tribe as Caraipa, Mesua and Calophyllum. Six known glycosidic flavonoids: quercetin 3-β-O-galactopyranoside (1), quercetin 3-β-O-glucopyranoside (2), quercetin 3-O-α-rhamnoside (3), luteolin 6-C-β-glucopyranoside (4), isovitexin (5), kaempferol 3-O-α-rhamnoside (6) and one triterpene, lupenone (7) were isolated, for the first time, from organic crude extract of Kielmeyera variabilis Mart. & Zucc., Calophyllaceae, leaves. The crude organic extract from K. variabilis leaves exhibited 95% of leishmanidal activity at 20 µg/mL on amastigote-like form of Leishmania (Leishmania) amazonensis in vitro model and only compound 3 showed 40-45% of growth inhibition at concentration ranging from 0.78 to 20 µg/mL. In addition, quercetin 3-O-α-rhamnoside (quercitrin) was found to be the major metabolite. Our results and previous reports suggest that synergistic effects of flavonoid glycosides are the cause of significant leishmanidal activity of the crude organic extract from K. variabilis leaves.

show abstract

Section: Resultsmentioning

confidence: 57%

Section: Resultsmentioning

confidence: 99%

Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis

Cota¹,

Siqueira²,

Oliveira³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…Peak 4 ( Rt = 52.8 min) was identified by matching the retention time with that of an authentic sample of the disprorinol A, a 4‐propylcoumarin previously isolated from K . rugosa (Nogueira et al ., ).…”

Section: Resultsmentioning

confidence: 97%

“…The methanolic extract of K . rugosa was obtained according to what has been described(Nogueira et al ., ). The stems (397.4 g) of K .…”

Section: Methodsmentioning

confidence: 97%

See 1 more Smart Citation

Involvement of Cerebral Nervous System Areas and Cytokines on Antihyperalgesic and Anti‐Inflammatory Activities of Kielmeyera rugosa Choisy (Calophyllaceae) in Rodents

Melo

Brito

Santos

et al. 2014

Phytotherapy Research

View full text Add to dashboard Cite

Kielmeyera rugosa is a medicinal plant known in Northeastern Brazil as 'pau-santo', and it is used in the treatment of several tropical diseases such as malaria, schistosomiasis, and leishmaniasis. We evaluated antihyperalgesic and anti-inflammatory activities of methanol stem extract of K. rugosa (MEKR) in mice. The mechanical hyperalgesia induced by carrageenan and tumor necrosis factor-alpha (TNF-α), prostaglandin E2 , and dopamine were assessed. We also investigated the anti-inflammatory effect of MEKR on carrageenan-induced pleurisy and paw edema. Ninety minutes after the treatment, the animals were submitted to an imunofluorescence for Fos protein. MEKR (100, 200, and 400 mg/kg; p.o.) inhibited the development of mechanical hypernociception and edema. MEKR significantly decreased TNF-α and interleukin 1β levels in pleural lavage and suppressed the recruitment of leukocytes. MEKR (1, 10, and 100 mg/mL) did not produce cytotoxicity, determined using the methyl-thiazolyl-tetrazolium assay in vitro. The locomotor activity was not affected. MEKR activated significantly the bulb olfactory, piriform cortex, and periaqueductal gray of the central nervous system. Our results provide first time evidence to propose that MEKR attenuates mechanical hyperalgesia and inflammation, in part, through an activation of central nervous system areas, mainly the periaqueductal gray and piriform cortex areas.

show abstract