Chemical constituents from Laggera pterodonta

Xie, Yan-Qing; Fan, Wei-Tong; Chen, Xuan‐Qin; Li, Rong‐Tao; Zhang, Zhijun

doi:10.1016/j.bse.2020.104222

Cited by 3 publications

(1 citation statement)

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“…This plant has long been used as folk medicine in China, and has been widely used clinically, with antioxidant, anti-tumor, antibacterial and analgesic effects. Previous studies on its constituents revealed that eudesmane-type sesquiterpene are one of the main secondary metabolites of this plant (Zhao et al, 1997;Yang et al, 2007;Lu et al, 2014;Xie et al, 2021). Sesquiterpenes are an important class of terpenoids with extensive biological activities, which have attracted our attention.…”

Section: Introductionmentioning

confidence: 99%

Acetylcholinesterase inhibitory activity of sesquiterpenoids isolated from Laggera pterodonta

Li²,

Wu³

et al. 2023

Front. Plant Sci.

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Plant-derived natural products are important resources for pesticide discovery. Acetylcholinesterase (AChE) is a well-validated pesticide target, and inhibiting AChE proves fatal for insects. Recent studies have shown that the potential of various sesquiterpenoids as AChE inhibitors. However, few studies have been conducted with eudesmane-type sesquiterpenes with AChE inhibitory effects. Therefore, in this research, we isolated two new sesquiterpenes, laggeranines A (1) and B (2), along with six known eudesmane-type sesquiterpenes (3–8) from Laggera pterodonta, and characterized their structures and the inhibitory effect they exerted on AChE. The results showed that these compounds had certain inhibitory effects on AChE in a dose-dependent manner, of which compound 5 had the best inhibitory effect with IC50 of 437.33 ± 8.33 mM. As revealed by the Lineweaver-Burk and Dixon plots, compound 5 was observed to suppress AChE activity reversibly and competitively. Furthermore, all compounds exhibited certain toxicity levels on C. elegans. Meanwhile, these compounds had good ADMET properties. These results are significant for the discovery of new AChE targeting compounds, and also enrich the bioactivity activity repertoire of L. pterodonta.

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Section: Introductionmentioning

confidence: 99%