Chemical Constituents from &lt;I&gt;Cichorium glandulosum&lt;/I&gt;

Yang, Wenzhi; Wang, Hao; Shang, Jing; Feng, Feng; Xie, Ning

doi:10.3724/sp.j.1009.2009.00193

Cited by 10 publications

(5 citation statements)

References 3 publications

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“…The characteristics of these three components ( Fig. 7 ) have been discussed in our previous work 21 . The structure similarity is that they are flavanoids, and have the same quercetin moieties.…”

Section: Resultsmentioning

confidence: 90%

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Lipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes

Ding

Liu

Hassan

et al. 2014

Sci Rep

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To investigate a possible methodology of exploiting herbal medicine and design polytherapy for the treatment of non-alcoholic fatty liver disease (NAFLD), we have made use of Cichorium glandulosum Boiss et Huet (CG), a traditional Chinese herbal medicine that has been proven to be effective in treating hepatic diseases. Here, we report that the extract of CG effectively reduced lipid accumulation under conditions of lipid overloading in vivo and in vitro (in a rat high-fat diet model and a hepG2 cell model of free fatty acid treatment). CG extract also protected hepatocytes from injury and inflammation to aid its lipid-lowering properties (in a rat high-fat diet model and a L02 cell model of acetaminophen treatment). Serum chemistry analysis accompanied by in vitro drug screening confirmed that CG-4, CG-10 and CG-14 are the lipo-effective components of CG. Western blotting analysis revealed that these components can regulate key lipid targets at the molecular level, including CD36, FATP5 and PPAR-α, thus the lipid oxidation and lipid absorption pathways. Finally, we adopted the experimental design and statistical method to calculate the best combination proportion (CG-4: CG-10: CG-14 = 2.065: 1.782: 2.153) to optimize its therapeutic effect.

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Section: Resultsmentioning

confidence: 90%

“…Bezafibrate was provided by Tasly Pharmaceutical Co. Ltd. Four CG compounds (CG-3, CG-4, CG-10, CG-14) were extracted and separated in a pharmaco-chemistry laboratory at the China Pharmaceutical University using the method described in our previous study 21 .…”

Section: Methodsmentioning

confidence: 99%

Lipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes

Ding

Liu

Hassan

et al. 2014

Sci Rep

Self Cite

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“…In recent years, many studies have reported that Cichorium glandulosum exerts hepatoprotective and antilipemic effects, and promotes digestion [8]. Flavonoids such as quercetin and isorhamnetin are some of the main active components of Cichorium glandulosum [9,10]. Based on the above-mentioned folkloric medical application of Cichorium glandulosum, total flavonoids from Cichorium glandulosum roots (TFCG) may show anti-liver fibrotic effects.…”

Section: Introductionmentioning

confidence: 99%

Studies on the protective effect of total flavonoids from <i>Cichorium glandulosum</i> roots against carbon tetrachloride-induced liver fibrosis in rats

Qin¹,

Hu²,

Yu³

et al. 2019

Trop. J. Pharm Res

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Purpose: To study the protective influence of total flavonoids from Cichorium glandulosum roots (TFCG) against carbon tetrachloride-mediated hepatic fibrosis in rats, and the probable mechanism of action involved. Methods: Rats with liver fibrosis were orally administered TFCG (50, 100 or 200 mg/kg) once a day for 13 weeks. Liver index and liver injury indices in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP), lactate dehydrogenase (LDH), γ-glutamyl transpeptidase (γ-GT), hydroxyproline (HYP), albumin (ALB) and malondialdehyde (MDA) were determined using electronic balance or corresponding assay kits, as appropriate. Following staining with hematoxylin and eosin and Van Gieson, histopathological changes in liver tissues were examined by light microscopy. TGF-β/Smad pathway-related protein expressions in liver tissues, viz, transforming growth factor-β1 (TGF-β1), mothers against decapentaplegic homolog 3 (Smad3), Smad7, toll-like receptor 4 (TLR4) and α-smooth muscle actin (α-SMA) were determined using immunohistochemical techniques. Results: Exposure to TFCG significantly reversed abnormal serum levels of ALT, AST, AKP, LDH, γ-GT, HYP, ALB and MDA rats with liver fibrosis to normal levels, and also decreased their liver index values (p < 0.01). Moreover, TFCG improved histopathological changes in the liver tissues of fibrotic rats, and significantly reversed abnormal TGF-β1, Smad3, Smad7, TLR4 and α-SMA protein expressions in the liver tissues of fibrotic rats to normal levels (p < 0.05 or 0.01). Conclusion: These results indicate that TFCG exerts protective effect against liver fibrosis via a mechanism related to inactivation of TGF-β/Smad pathway. Thus, TFCG may find application in liver fibrosis therapy.

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“…Among these, quercetin 3- O -β- D -glucuronide was firstly obtained from this compound, and the other compounds were first isolated from this plant. 16 The 2 red chicory varieties and green chicory were analyzed using HPLC/DAD/MS, and chromatographic fingerprinting was used to diagnose the chromatograms of different varieties. The red variety of chicory contained anthocyanin 3- O- glucoside and anthocyanin 3- O -(6-malonyl) glucoside.…”

Section: Chemical Compositionmentioning

confidence: 99%

Research Progress on the Homologous Effects of Cichorium glandulosum Boiss. et Huet on Medicine and Food: A Review

Yang,

Lei,

Yan

et al. 2024

Natural Product Communications

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Cichorium glandulosum Boiss. et Huet is a genus of chicory in the family of Asteraceae, and it is a “medicine food homology” herbal medicine, which has the effect of detoxifying heat, diuretic and swelling, and strengthening the stomach. This paper reviews the chemical composition, pharmacological effects, and practical applications of Cichorium glandulosum Boiss. et Huet and provides a comprehensive account of its role in human health and diet, pharmacological activities, and toxicity. Cichorium glandulosum Boiss. et Huet, “medicine food homology” herbal medicine, is often widely used in compound formulations with functions such as clearing the liver, promoting gallbladder, and enhancing immunity. Previous studies have found that multiple chemical components have been isolated and identified from Cichorium glandulosum Boiss. et Huet, mainly including 89 compounds such as flavonoids, terpenoids, phenolic acids, polysaccharides, and phenylpropanoids. Meanwhile, the extract has various biological activities, including hepatoprotective and hypoglycemic, regulating blood lipids, aiding digestion, anticancer, regulating intestinal microbiota and immune function, antioxidant, and has been proven in both in vivo and in vitro studies. As an important plant resource, the current research focuses on the traditional efficacy of Cichorium glandulosum Boiss. et Huet. The chemical composition of this genus of plants is complex and their pharmacological activities are diverse. Further in-depth studies on the molecular mechanisms and toxic side effects of its specific compounds in the organism are needed. Therefore, this review provides a reference for the development and utilization of Cichorium glandulosum Boiss. et Huet.

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Chemical Constituents from <I>Cichorium glandulosum</I>

Cited by 10 publications

References 3 publications

Lipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes

Lipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes

Studies on the protective effect of total flavonoids from <i>Cichorium glandulosum</i> roots against carbon tetrachloride-induced liver fibrosis in rats

Research Progress on the Homologous Effects of Cichorium glandulosum Boiss. et Huet on Medicine and Food: A Review

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