Chemical Constituents from the Chinese Bryophytes and Their Reversal of Fungal Resistance

Xie, Chunfeng; Lou, Hongxiang

doi:10.2174/138527208784577385

Cited by 15 publications

(4 citation statements)

References 50 publications

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“…Unique aromas can also be found among other bryophytes, e.g., Takakia lepidozioides S. Hatt. & Inoue is characterized by an aromatic blend of cinnamon and roasted wheat due to the presence of coumarin [42] (Table 2). The smells of bryophytes depend not only on contents of volatile secondary metabolites in their essential oils (Table 2), but also on plant habitat conditions, e.g., Frullania species produce tamariscol (1, Figure 1) only when grown in high mountain sites [19].…”

Section: Volatile Compoundsmentioning

confidence: 99%

Modern Use of Bryophytes as a Source of Secondary Metabolites

et al. 2022

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Bryophytes constitute a heterogeneous group of plants which includes three clades: approximately 14,000 species of mosses (Bryophyta), 6000 species of liverworts (Marchantiophyta), and 300 species of hornworts (Anthocerotophyta). They are common in almost all ecosystems, where they play important roles. Bryophytes lack developed physical barriers, yet they are rarely attacked by herbivores or pathogens. Instead, they have acquired the ability to produce a wide range of secondary metabolites with diverse functions, such as phytotoxic, antibacterial, antifungal, insect antifeedant, and molluscicidal activities. Secondary metabolites in bryophytes can also be involved in stress tolerance, i.e., in UV-absorptive and drought- and freezing-tolerant activities. Due to these properties, for centuries bryophytes have been used to combat health problems in many cultures on different continents. Currently, scientists are discovering new, unique compounds in bryophytes with potential for practical use, which, in the age of drug resistance, may be of considerable importance. The aim of this review is to present bryophytes as a potential source of compounds with miscellaneous possible uses, with a focus on volatile compounds and antibacterial, antifungal, and cytotoxic potential, and as sources of materials for further promising research. The paper also briefly refers to the methods of compound extraction and acquisition. Formulas of compounds were drawn by the authors using ChemDraw software (PerkinElmer, Boston, MA, USA) with reference to data published in various papers, the ACD/Labs dictionary database, PubChem, and Scopus. The data were gathered in February 2022.

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Section: Volatile Compoundsmentioning

confidence: 99%

Modern Use of Bryophytes as a Source of Secondary Metabolites

et al. 2022

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“…It has been proved that these cryptograms are rich source of bioactive secondary metabolites and can easily be exploited as an alternative source of fungicidal compounds. As they grow in marshy habitats and can protect themselves from biotic (ultraviolet rays, heat stress, and predation) and abiotic stress (fungal or bacterial attack), they are store house of diverse bioactive chemicals (Xie and Lou 2008). Members of Hepaticopsida and mosses (the evolved members of bryophytes) are known to possess antifungal activity and are rich source of flavonoids, terpenoids, bibenzyls, and fatty acids of therapeutic importance (Krzaczkowski et al 2008).…”

Section: Plant Amphibians As An Alternative Sourcementioning

confidence: 99%

Natural Products as Fungicide and Their Role in Crop Protection

Santra

Banerjee

2020

Natural Bioactive Products in Sustainable Agriculture

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Seeking solutions from nature for solving one and all problems is the age-old practice for mankind, and natural products are proved to be the most effective one for keeping up the balance of development as well as the "healthy, wealthy, and well" condition of mother nature. Fungal pathogens are proved to be a common and popular contaminant of agroecosystem that approximately causes 70-80% of total microbial crop loss. To meet the proper global increasing need of food products as a result of population explosion, managing agricultural system in an eco-friendly and profitable manner is the prime target; thus the word "sustainable agriculture" plays it part, and this package is highly effective when coupled with nature-derived fungicidal products that can minimize the event of fungal infections in agrarian ecosystem. Present study enlists the most common and effective natural products that might be of plant or microbial origin, their mode of action, day-by-day development of phytopathogenic resistance against the prevailing fungicides, and also their role in maintenance of sustainability of agricultural practices with special emphasis on their acceptance over the synthetic or chemical one. A large number of bioactive compounds ranging from direct plant (both cryptogams algae and moss and phanerogams)-derived natural extracts, essential oil of aromatic plants, and low-molecular-weight antimicrobial compounds known as phytoalexins to secondary metabolites that are both volatile and nonvolatile organic compounds of microbes (fungal and actinobacterial members) residing inside the host tissue, called endophyte, are widely used as agricultural bioweapons. The rhizospheric partners of plant, mycorrhizae, are also a prime agent of this chemical warfare and protect their green partners from fungal invaders and emphasize the concept of "sustainable agriculture." 132

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“…Further investigations indicated that impairment of the yeast proteasomal activity might be involved in the mode of action of tea polyphenols against C. albicans [104]. Bisbibenzyl compounds are exclusively found in liverworts and are known to exhibit antifungal activity [105][106][107]. In 2009 it was demonstrated that riccardin D, a macrocyclic bisbibenzyl isolated from the Chinese liverwort Dumortiera hirsuta, causes a remarkable reduction in the metabolic activity of C. albicans biofilm cells at concentrations that are not toxic for RPE1 or LO2 cell lines [108,109].…”

Section: Novel Anti-biofilm Agentsmentioning

confidence: 99%

Anti-Biofilm Strategies: How to Eradicate Candida Biofilms?

Bink¹,

Pellens²,

Cammue

et al. 2011

TOMYCJ

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In nature, microorganisms prefer to reside in structured microbial communities, termed biofilms, rather than as free-floating planktonic cells. Advantageous for the microorganisms, but disadvantageous for human health, is the increased resistance/tolerance of the biofilm cells to antimicrobial treatment. In clinically relevant biofilms, Candida albicans is one of the most frequently isolated microorganisms in biofilms. This review primarily elaborates on the activity of the currently used antimycotics against Candida biofilms, the potential of antifungal lock therapy and sheds more light on new promising compounds resulting from the gradual shift of anti-biofilm research activities to natural products, plants and their extracts.

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Chemical Constituents from the Chinese Bryophytes and Their Reversal of Fungal Resistance

Cited by 15 publications

References 50 publications

Modern Use of Bryophytes as a Source of Secondary Metabolites

Modern Use of Bryophytes as a Source of Secondary Metabolites

Natural Products as Fungicide and Their Role in Crop Protection

Anti-Biofilm Strategies: How to Eradicate Candida Biofilms?

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