Chemical constituents from the fruits of Vitex trifolia L. (Verbenaceae) and their chemotaxonomic significance

Djimabi, Komi; Li, Bing; Chen, Xiaohan; Su, Pan-Jie; Liu, Xu; Wang, Ru-Yue; Qi, Feng‐Ming; Wang, Mei-Jie; Fei, Dong‐Qing; Zhang, Zhan‐Xin

doi:10.1016/j.bse.2021.104305

Cited by 5 publications

(7 citation statements)

References 47 publications

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“…Most of the V. trifolia monoterpenoids are iridoids and their corresponding glycosides (metabolites 1 – 10 ). Besides the iridoids, an acyclic monoterpenoid vitexoid ( 15 ) has been isolated from the fruits and is a characteristic metabolite of V. trifolia ( Djimabi et al, 2021 ). Only two aromadendrane-type sesquiterpenoids ( 16 and 17 ) were found in the fruits ( Gu et al, 2007 ).…”

Section: Biosynthesis Of Terpenoids Flavonoids and Iridoidsmentioning

confidence: 99%

“…Abietanes diterpenoids ( 85 – 89 ) have been isolated from the fruit’s extracts or non/semi-polar fractions ( Ono et al, 2000 ; Li et al, 2020b ; Djimabi et al, 2021 ). From this plant, aromatic five abietanes, known as the most abundant naturally occurring abietanes, including abietatrien-3 β -ol ( 86 ) , ferruginol ( 87 ), 3 β -acetoxyabieta-8,11,13-triene-12-ol ( 88 ), and vitexifolin C ( 89 ) have been isolated ( Gonzalez, 2015 ).…”

Section: Biosynthesis Of Terpenoids Flavonoids and Iridoidsmentioning

confidence: 99%

“…Djimabi et al identified helipterol ( 90 ), possessing a monocyclic scaffold, from the fruit alcoholic extract V. trifolia , as the only natural source which is so far reported ( Djimabi et al, 2021 ). Moreover, viterotulin D ( 37 ), vitetrifolin H ( 79 ), 15,16-epoxy-9-hydroxylabda-13 (16),14-diene ( 29 ), and 3 β -acetoxyabieta-8,11,13-trien-12-ol ( 88 ) were screened out to be the specific secondary metabolites ( Wu et al, 2009b ).…”

Section: Biosynthesis Of Terpenoids Flavonoids and Iridoidsmentioning

confidence: 99%

“…In Vitex trifolia , the most abundant subclasses of triterpenoids identified are oleanane, ursane, and lupane, with 92 to 110 representative compounds ( Figure 3 ). Additionally, one metabolite with a taraxerane skeleton (compound 111 ) has been isolated, further enriching the chemical profile of this species ( Yong-Sheng Chen et al, 2010 ; Djimabi et al, 2021 ). Given the abundance of triterpenoids in their free form in V. trifolia , Mohamed et al have successfully identified three triterpenoid saponins ( 97 – 99) derived from the leaves ( Mohamed et al, 2013 ).…”

Section: Biosynthesis Of Terpenoids Flavonoids and Iridoidsmentioning

confidence: 99%

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A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

Mottaghipisheh,

Kamali,

Doustimotlagh

et al. 2024

Front. Pharmacol.

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Plants, renowned for their rich reservoir of metabolites, play a pivotal role in addressing health-related issues. The Verbenaceae family stands out, showcasing immense potential in preventing and treating chronic diseases. Vitex trifolia L. (V. trifolia), a shrub with a rich history in traditional medicine, particularly in Eastern Asia, has garnered attention for its diverse therapeutic applications. This comprehensive review aims to bridge traditional knowledge and contemporary insights by investigating ethnopharmacology, phytochemistry, and pharmacological effects of V. trifolia. The keyword “V. trifolia” and its synonyms were searched within the main scientific databases including PubMed, Web of Science, ScienceDirect, Google Scholar, and Baidu Scholar (from 1974 to 2022, last search: 21.10.2023). Phytochemical analyses reveal a spectrum of secondary metabolites in V. trifolia, including terpenoids, flavonoids, lignans, phytosterols, anthraquinones, and fatty acids. Notably, terpenoids and flavonoids emerge as the main bioactive metabolites. Pharmacological studies validate its therapeutic potential, demonstrating significant antioxidant, anti-inflammatory, hepatoprotective, anticancer, anti-amnesic, antimicrobial, antiviral, anti-malaria, antispasmodic activities, and reported insecticidal effects. Despite existing literature exploring pharmacological attributes and secondary metabolites of related species, a conspicuous gap exists, specifically focusing on the pharmacological activities and novel methods of purification of pure metabolites from V. trifolia. This review aimed to fill this gap by delving into traditional medicinal applications, exploring secondary metabolites comprehensively, and providing an in-depth analysis of pharmacological effects of pure metabolites. Combining traditional uses with contemporary pharmacological insights, this article sought to serve as a crucial reference for future research and practical application of V. trifolia. This approach contributes substantially to understanding the plant, fostering scientific inquiry, and facilitating its broader application in healthcare.

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Section: Biosynthesis Of Terpenoids Flavonoids and Iridoidsmentioning

confidence: 99%

Section: Biosynthesis Of Terpenoids Flavonoids and Iridoidsmentioning

confidence: 99%

Section: Biosynthesis Of Terpenoids Flavonoids and Iridoidsmentioning

confidence: 99%

Section: Biosynthesis Of Terpenoids Flavonoids and Iridoidsmentioning

confidence: 99%

See 2 more Smart Citations

A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

Mottaghipisheh,

Kamali,

Doustimotlagh

et al. 2024

Front. Pharmacol.

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“…There are 161 compounds reported from this species, such as iridoids, diterpenoids, ecdysteroids, flavonoids, and phenolic compounds [20]. Phenolic compounds commonly found in this genus are vanillic acid, ferulic acid, p-coumaric acid, 3,4-dihydroxybenzoate acid, casticin, caffeic acid, gallic acid, chlorogenic acid, isochlorogenic acid, vitexin [21][22][23][24][25]. Vitex pinnata Linn is a plant species from the Vitex genus with a wide range of phenolic compounds, such as methyl p-hydroxybenzoate, vicioside, apigenin, retusin, and kaemferol trimethyl ether [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity-Guided Isolation of Phenolic Compounds from Leaves of Vitex pinnata (Lamiaceae)

Faisal

Efdi

Itam

et al. 2022

CSIJ

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The aim of this study is to isolate phenolic compounds from the ethyl acetate fraction of the leaves of V. pinnata Linn, which have antioxidant properties, guided by a TLC-Bioautography (Thin-layer chromatography) with a reagent of 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The TLC-antioxidant bioautography technique has several advantages. It does not require a long time in testing, the sample used is small, and it can potentially obtain promising antioxidant-positive compounds.The isolation process led to obtaining two phenolic compounds. The UV-Vis, FTIR, and NMR spectrum analysis showed that the compounds were (1) p-hydroxybenzoate and (2) luteolin. Further antioxidant evaluation by DPPH assay showed a potential radical scavenging DPPH of luteolin (2) with an IC50 of 1.56±0.18 µg/mL.

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Diterpenoids with α-glucosidase inhibitory activities from the fruits of Vitex trifolia Linn

Djimabi

Wang

et al. 2022

Fitoterapia

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Chemical constituents from the fruits of Vitex trifolia L. (Verbenaceae) and their chemotaxonomic significance

Cited by 5 publications

References 47 publications

A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

Antioxidant Activity-Guided Isolation of Phenolic Compounds from Leaves of Vitex pinnata (Lamiaceae)

Diterpenoids with α-glucosidase inhibitory activities from the fruits of Vitex trifolia Linn

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