Chemical Constituents Isolated from Lycium shawii and their Chemotaxonomic Significance

Rehman, Najeeb Ur; Hussain, Hidayat; Al-Riyami, Samia Ahmed; Green, Ivan R.; Al‐Harrasi, Ahmed

doi:10.25135/rnp.34.17.09.160

Cited by 13 publications

(10 citation statements)

References 13 publications

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“…In line with the study of Hussain et al (2010) andBrito et al (2014), MS/MS spectra of S. tomentosa and S. condensata at m/z 299 and 313 with the neutral loss of methyl ether were attributed to diosmetin and luteolin-dimethyl ether (Table 2). As shown in previously published works, luteolin-methyl ether was characterized in Phlomis cashmeriana Royle ex Benth.…”

Section: Discussionsupporting

confidence: 76%

Acta Biologica Cracoviensia s. Botanica

Dehkordi¹,

Kharazian²,

Lorigooini³

2020

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The genus Scutellaria L., Lamiaceae family, Scutellarioideae sub-family is known as the most important medicinal plant in the world. This research aimed to investigate the flavonoid content of seven Scutellaria species from the center, southwest, and west of Iran. Via thin layer and column chromatography, the flavonoid was extracted from leaves and then purified. To screen the flavonoid compositions, a chromatographic method was applied by liquid chromatography mass spectrometry on a triple quadrupole mass spectrometer (LC/TQMS/MS). Fingerprint analysis was implemented so as to characterize a total of 73 chemical compounds, from which 71 compounds were flavonoids belonging to different classes. Flavone with 37 derivatives possessed major values. The most abundant flavonoid compounds were observed in S. multicaulis (23 compounds) and S. patonii (22 compounds). Flavonoid composition, including apigenin, kaempferol, quercetin, and hydroxylflavones represented remarkable derivatives. A total of 45 flavonoids, one tannin and one anthraquinone compound, were observed to be primarily separated and identified for Scutellaria species. Moreover, six categorized chemical groups were identified in this genus and proposed as chemical barcodes. The specific chemical groups strongly provided the boundaries of Scutellaria species, the pharmacological value enhancement, breeding programs, and comprehensive documents of the species. According to the results, LC/TQMS/MS was proven a dominant method regarding genus Scutellaria.

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Section: Discussionsupporting

confidence: 76%

Acta Biologica Cracoviensia s. Botanica

Dehkordi¹,

Kharazian²,

Lorigooini³

2020

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“…The molecular features were extracted by screening the detected nodes at various retention times per minute, with a minimum intensity of 6,000 counts, and aligned with previously detected compounds considering adducts ([M + H] + , [M+2H] + , and [M-H] - ). The identified derivative metabolites were (peak A) P-coumaric acid (4-hydroxycinnamic acid) ( Pei et al, 2016 ); (peak B) aloe-emodin ( Rehman et al, 2018 ); (peak C) oxalic acid isobutyl pentyl ester (2-methylpropyl pentyl ethanedioate) ( Singariya et al, 2015 ); (peak D) di-n-octyl phthalate (dioctyl 1,2 benzenedicarboxylate) ( DeAngelo et al, 1986 ); (peak E) apigenin (4,5,6-trihydroxy flavone) ( Shukla and Gupta, 2010 ); (peak F) chrysophanol-8-O-β-D-glucoside ( Rehman et al, 2016 ); (peak G) nonacosan-10-ol, ( Yao et al, 2011 ); (peak H) lyciumate ( Rehman et al, 2019 ); and (peak I) betulinic acid ( Yao et al, 2011 ), and means m/z implies measured m/z.…”

Section: Resultsmentioning

confidence: 99%

“… Base peak chromatograms of the L. shawii methanolic extract were extracted, and tentatively identified secondary metabolites are as follows: P-coumaric acid (4-hydroxycinnamic acid) ( Pei et al, 2016 ) (A), aloe-emodin ( Rehman et al, 2018 ) (B), oxalic acid isobutyl pentyl ester (2-methylpropyl pentyl ethanedioate) ( Singariya et al, 2015 ) (C), di-n-octyl phthalate (dioctyl 1,2 benzenedicarboxylate) ( DeAngelo et al, 1986 ) (D) , apigenin (4,5,6-trihydroxy flavone) ( Shukla and Gupta, 2010 ) (E) , chrysophanol-8-O-β-D-glucoside ( Rehman et al, 2016 ) (F) , nonacosan-10-ol ( Yao et al, 2011 ) (G) , lyciumate ( Rehman et al, 2019 ) (H) , betulinic acid ( Yao et al, 2011 ) (I) , and m/z implies measured m/z . …”

Section: Resultsmentioning

confidence: 99%

Stimulatory effects of Lycium shawii on human melanocyte proliferation, migration, and melanogenesis: In vitro and in silico studies

et al. 2023

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There is no first-line treatment for vitiligo, a skin disease characterized by a lack of melanin produced by the melanocytes, resulting in an urgent demand for new therapeutic drugs capable of stimulating melanocyte functions, including melanogenesis. In this study, traditional medicinal plant extracts were tested for cultured human melanocyte proliferation, migration, and melanogenesis using MTT, scratch wound-healing assays, transmission electron microscopy, immunofluorescence staining, and Western blot technology. Of the methanolic extracts, Lycium shawii L. (L. shawii) extract increased melanocyte proliferation at low concentrations and modulated melanocyte migration. At the lowest tested concentration (i.e., 7.8 μg/mL), the L. shawii methanolic extract promoted melanosome formation, maturation, and enhanced melanin production, which was associated with the upregulation of microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1 and TRP-2 melanogenesis-related proteins, and melanogenesis-related proteins. After the chemical analysis and L. shawii extract-derived metabolite identification, the in silico studies revealed the molecular interactions between Metabolite 5, identified as apigenin (4,5,6-trihydroxyflavone), and the copper active site of tyrosinase, predicting enhanced tyrosinase activity and subsequent melanin formation. In conclusion, L. shawii methanolic extract stimulates melanocyte functions, including melanin production, and its derivative Metabolite 5 enhances tyrosinase activity, suggesting further investigation of the L. shawii extract-derived Metabolite 5 as a potential natural drug for vitiligo treatment.

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“…Lyciumate, cyclopentapyrrolidine, imidazole, piperidine, nortropane, tropane, pyrrole, spermine, costunolide, catechin, lyciumaside, emodin, betulinic acid, β-sitosterol glucopyranoside, quercetin, gallic acid, rutin, ρ-coumaric acid, ferulic acid [177,178] Reported data revealed that LD 50 of the L. shawii extract was greater than 2000 mg/kg b.w in animal model [179].…”

Section: Lycium Shawiimentioning

confidence: 99%

Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia

Alqahtani

Ullah

Shahat

2022

Evidence-Based Complementary and Alternative Medicine

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The purpose of this review is to summarize the available antidiabetic medicinal plants in the Kingdom of Saudi Arabia with its phytoconstituents and toxicological findings supporting by the latest literature. Required data about medicinal plants having antidiabetic activities and growing in the Kingdom of Saudi Arabia were searched/collected from the online databases including Wiley, Google, PubMed, Google Scholar, ScienceDirect, and Scopus. Keywords used in search are in vivo antidiabetic activities, flora of Saudi Arabia, active ingredients, toxicological evaluations, and medicinal plants. A total of 50 plant species belonging to 27 families were found in the flora of Saudi Arabia. Dominant family was found Lamiaceae with 5 species (highest) followed by Moraceae with 4 species. β-Amyrin, β-sitosterol, stigmasterol, oleanolic acid, ursolic acid, rutin, chlorogenic acid, quercetin, and kaempferol are the very common bioactive constituents of these selected plant species. This paper has presented a list of antidiabetic plants used in the treatment of diabetes mellitus. Bioactive antidiabetic phytoconstituents which showed that these plants have hypoglycemic effects and highly recommended for further pharmacological purposes and to isolate/identify antidiabetes mellitus (anti-DM) active agents also need to investigate the side effects of active ingredients.

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Chemical Constituents Isolated from Lycium shawii and their Chemotaxonomic Significance

Cited by 13 publications

References 13 publications

Acta Biologica Cracoviensia s. Botanica

Acta Biologica Cracoviensia s. Botanica

Stimulatory effects of Lycium shawii on human melanocyte proliferation, migration, and melanogenesis: In vitro and in silico studies

Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia

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