Chemical constituents isolated from Valeriana officinalis L

Fan, Hao; Li, Yuze; Liang, Xiaofei; Yan, Shu-Ting; Cui, Yuwen; Zhang, Huawei; Huang, Wenli; Yang, Xinjie; Song, Xiaomei

doi:10.1016/j.bse.2020.104143

Cited by 9 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Forty-three known compounds isolated during this project were characterized as lancilactone B ( 9 ) ( Chen et al, 1999 ), kadsudilactone ( 10 ) ( Rui et al, 1991 ), schisanlactone B ( 11 ) ( Liu et al, 1983b ), kadsuphilactone B ( 12 ) ( Shen et al, 2005 ), xuetongsu ( 13 ) ( Shehla et al, 2020 ), heteroclitalactone A ( 14 ) ( Wang et al, 2006a ), changnanic acid ( 15 ) ( Liu and Huang, 1991 ), cycloartenone ( 16 ) ( Wang et al, 2006a ), schizandronic acid ( 17 ) ( Li et al, 2003 ), seco -coccinic acid F ( 18 ) ( Minh et al, 2014 ), kadsuracoccinic acid B ( 19 ) ( Li et al, 2008 ), sorghumol ( 20 ) ( Cambie et al, 1992 ), heteroclitalignan D ( 21 ) ( Wang et al, 2006b ), kadsurarin ( 22 ) ( Chen et al, 1973 ), kadsuphilol T ( 23 ) ( Cheng et al, 2011 ), kadsuphilol R ( 24 ) ( Cheng et al, 2011 ), kadsuphilol C ( 25 ) ( Luo et al, 2017 ), kadsulignan N ( 26 ) ( Gao et al, 1998 ), enshizhisu ( 27 ) ( Huang et al, 1982 ), machilolin A ( 28 ) ( Chen et al, 2009 ), (+)-pinoresinol ( 29 ) ( Fan et al, 2020 ), (+)-2-(3,4-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-3,7-dioxabicyclo [3,3,0] octane ( 30 ) ( Latip et al, 1999 ), meso -dihydroguaiaretic acid ( 31 ) ( Lu and Chen, 2008 ), 6α,9α-dihydroxycadinan-4-en-3-one ( 32 ) ( Cao et al, 2019c ), (4 R )-4-hydroxy-1,10- seco -muurol-5-ene-1,10-dione ( 33 ) ( Kiem et al, 2014 ), litseachromolaevane A ( 34 ) ( Zhang et al, 2003 ), cryptomeridiol ( 35 ) ( Ragasa et al, 2005 ), (-)-5 β ,11-dihydroxyiphionan-4-one ( 36 ) ( Lin et al, 2019 ), aromadendrane-4 β ,10 α -diol ( 37 ) ( Goldsby and Burke, 1987 ), lochmolin F ( 38 ) ( Tseng et al, 2012 ), loliolide ( 39 ) ( Kim et al, 2004 ), β- sitosterol ( 40 ) ( Luo et al, 2009 ), daucosterol ( 41 ) ( Tezuka et al, 1998 ), stigmasterol ( 42 ) ( Luo et al, 2009 ), schleicheol 2 ( 43 ) ( Pettit et al, 2000 ), 7-hydroxy- β- sito...…”

Section: Resultsmentioning

confidence: 99%

Anti-RAFLS Triterpenoids and Hepatoprotective Lignans From the Leaves of Tujia Ethnomedicine Kadsura heteroclita (Xuetong)

et al. 2022

View full text Add to dashboard Cite

A pair of 3,4-seco-cycloartane triterpenoid isomers with a rare peroxy bridge, namely, xuetonins A and B (1 and 2), four new lignans xuetonlignans A–D (3–6), a new sesquiterpene xuetonpene (7), and a new natural product xuetonin C (8), along with 43 known compounds, were obtained from the leaves of Tujia ethnomedicine, Kadsura heteroclita. Their structures and configurations were determined with the help of a combination of 1D- and 2D-NMR, HRESIMS spectra, electronic circular dichroism (ECD), and X-ray diffraction data. Compounds 2, 10, 13–15, and 17–19 showed moderate-to-potent activity against rheumatoid arthritis fibroblast-like synoviocytes (RAFLS) with IC50 values of 19.81 ± 0.26, 12.73 ± 0.29, 5.70 ± 0.24, 9.25 ± 0.79, 5.66 ± 0.52, 11.91 ± 0.44, 13.22 ± 0.27, and 15.94 ± 0.36 μM, respectively. Furthermore, compounds 22, 25, and 31 exhibited significant hepatoprotective effects against N-acetyl-p-aminophenol (APAP)–induced toxicity in HepG2 cells at 10 μM, and the cell viability increased by 12.93, 25.23, and 13.91%, respectively, compared with that in the model group (cf. bicyclol, 12.60%).

show abstract

Section: Resultsmentioning

confidence: 99%

Anti-RAFLS Triterpenoids and Hepatoprotective Lignans From the Leaves of Tujia Ethnomedicine Kadsura heteroclita (Xuetong)

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The activities of other lignans, including 8′-hydroxypinoresinol ( 260 ), pinoresinol-4-O- β -D-glucopyranoside ( 261 ), 8′-hydroxypinoresinol-4′-O- β -D-glucopyranoside ( 263 ) ( Schumacher et al, 2002 ; Wang et al, 2012b ; Quan L. Q. et al, 2020 ), and (+)-1-acetoxypinoresinol ( 269 ) ( Fan et al, 2020 ), have not been determined in a phytochemical study of Valeriana . The details are shown in Supplementary Table S2 of the supplementary material.…”

Section: Phytochemistrymentioning

confidence: 99%

The potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry

Wang

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Valeriana plants are members of the Caprifoliaceae family, which include more than 200 species worldwide. We summarized previous reports on traditional clinical applications, bioactivities, and phytochemistry of Valeriana by searching electronic databases of Science Direct, Web of Science, PubMed, and some books. Some Valeriana species have been used as traditional medicines, demonstrating calming fright and tranquilizing mind, promoting Qi and blood, activating blood circulation and regulating menstruation, dispelling wind and eliminating dampness, regulating Qi-flowing to relieve pain, and promoting digestion and checking diarrhea, and treating diseases of the nervous, cardiovascular, and digestive systems, inflammation, gynecology, and others. Pharmacology studies revealed the effects of Valeriana, including sedative, hypnotic, antispasmodic, analgesic, antidepressant, anxiolytic, anticonvulsant, antiepileptic, neuroprotective, antibacterial, antiviral, cytotoxic, and antitumor effects as well as cardiovascular and cerebrovascular system improvements. More than 800 compounds have been isolated or identified from Valeriana, including iridoids, lignans, flavonoids, sesquiterpenoids, alkaloids, and essential oils. Constituents with neuroprotective, anti-inflammatory, cytotoxic, and sedative activities were also identified. However, at present, the developed drugs from Valeriana are far from sufficient. We further discussed the pharmacological effects, effective constituents, and mechanisms directly related to the traditional clinical applications of Valeriana, revealing that only several species and their essential oils were well developed to treat insomnia. To effectively promote the utilization of resources, more Valeriana species as well as their different medicinal parts should be the focus of future related studies. Clinical studies should be performed based on the traditional efficacies of Valeriana to facilitate their use in treating diseases of nervous, cardiovascular, and digestive systems, inflammation, and gynecology. Future studies should also focus on developing effective fractions or active compounds of Valeriana into new drugs to treat diseases associated with neurodegeneration, cardiovascular, and cerebrovascular, inflammation and tumors. Our review will promote the development and utilization of potential drugs in Valeriana and avoid wasting their medicinal resources.

show abstract

“…As reference standards, the NMR and MS data about the isolated compounds were shown in Table 8. The detailed identification results were published in the previous article of our laboratory [27,28]. Methanol and acetic acid (HPLC grade) were obtained from J&K Medical (Beijing, China).…”

Section: Reagents and Samplesmentioning

confidence: 99%

Determination of Triterpenoids and Phenolic Acids from Sanguisorba officinalis L. by HPLC-ELSD and Its Application

et al. 2021

View full text Add to dashboard Cite

A novel analytical method involving high-performance liquid chromatography with evaporative light scattering detection (HPLC-ELSD) was developed for simultaneous determination of 11 phenolic acids and 12 triterpenes in Sanguisorba officinalis L. Chromatographic separation was conducted with gradient elution mode by using a DiamonsilTM C18 column (250 mm × 4.6 mm, 5 μm) with the mobile phase of 0.1% acetic acid water (A) and methanol (B). The drift tube temperature of ELSD was set at 70 °C and the nitrogen cumulative flow rate was 1.6 L/min. The method was fully validated to be linear over a wide concentration range (R2 ≥ 0.9991). The precisions (RSD) were less than 3.0% and the recoveries were between 97.7% and 101.4% for all compounds. The results indicated that this method is accurate and effective for the determination of 23 functional components in Sanguisorba officinalis L. and could also be successfully applied to study the influence of processing method on those functional components in Sanguisorba officinalis L.

show abstract

Chemical constituents isolated from Valeriana officinalis L

Cited by 9 publications

References 15 publications

Anti-RAFLS Triterpenoids and Hepatoprotective Lignans From the Leaves of Tujia Ethnomedicine Kadsura heteroclita (Xuetong)

Anti-RAFLS Triterpenoids and Hepatoprotective Lignans From the Leaves of Tujia Ethnomedicine Kadsura heteroclita (Xuetong)

The potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry

Determination of Triterpenoids and Phenolic Acids from Sanguisorba officinalis L. by HPLC-ELSD and Its Application

Contact Info

Product

Resources

About